DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d1 and CYP4A11

DIOPT Version :9

Sequence 1:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_000769.2	Gene:	CYP4A11 / 1579	HGNCID:	2642	Length:	519	Species:	Homo sapiens

Alignment Length:	517	Identity:	171/517 - (33%)
Similarity:	290/517 - (56%)	Gaps:	36/517 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VIGAILASALFVGLLL------YHLKFKRLIDLISYMPGPPVLPLVGHGHHFIGKPPHEMVKKIF 62
            |.|.:.|::|.:.|||      .:|..:.|:..:...|.||...|.||....   ...:.:::|.
Human    15 VSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLFGHIQEL---QQDQELQRIQ 76

  Fly    63 EFMETYSKDQVLKVWL-GPELNVLMGNPKDVEVVLGTLRFNDKA-GEYKALEPWLKEGLLVSRGR 125
            :::||:  ......|| |.::.|.:.:|..::|:||  |.:.|: |.|:.|.||:..|||:..|:
Human    77 KWVETF--PSACPHWLWGGKVRVQLYDPDYMKVILG--RSDPKSHGSYRFLAPWIGYGLLLLNGQ 137

  Fly   126 KWHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWINLCTMDTI--C 188
            .|.:.|:::|||||:.||..:|.:.....|.:|...|:  |...||...::..::|.|:|||  |
Human   138 TWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEE--LLGQDSPLEVFQHVSLMTLDTIMKC 200

  Fly   189 ETAMGVSINAQSNADSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKALNVLHQFTE 253
            ..:...||....|:.| |:||:..::.::..|:.|..::.|..|.||...|...:|..:.||.|:
Human   201 AFSHQGSIQVDRNSQS-YIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTD 264

  Fly   254 KIIVQRREELIREGSSQESSNDDADVGAKRKMAFLDILLQSTVDERP-LSNLDIREEVDTFMFEG 317
            ::|..|:.:|.:||..::       :..||.:.||||||.:.::... ||:.|:|.|||||||||
Human   265 QVIQLRKAQLQKEGELEK-------IKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEG 322

  Fly   318 HDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLCVKETLRMYPS 382
            ||||:|.:.:..|.:||||:.|::|.|||.|::|:..|  :::..|:|:.|..:|:||.||:||.
Human   323 HDTTASGISWILYALATHPKHQERCREEIHSLLGDGAS--ITWNHLDQMPYTTMCIKEALRLYPP 385

  Fly   383 VPLLGRKVLEDCEI-NGKLIPAGTNIGISPLYLGRREELFSEPNIFKPERFDVVTTAEKLNPYAY 446
            ||.:||::...... :|:.:|.|..:.:|...|....:::..|.:|.|.||   ......:.:|:
Human   386 VPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRF---APGSAQHSHAF 447

  Fly   447 IPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEPPVLIAELILRTKEPLMFKVR 508
            :|||.|.|||||::|||.|:|...|..|..:|:  :.|.:..|:.||.|:|::|..:..::|
Human   448 LPFSGGSRNCIGKQFAMNELKVATALTLLRFEL--LPDPTRIPIPIARLVLKSKNGIHLRLR 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	161/477 (34%)
CYP4A11	NP_000769.2	p450	52..505	CDD:278495	161/476 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154738
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750