Protein Alignment Cyp4d1 and CYP3A5

DIOPT Version :10

• Sequence 1: NP_476907.2
• Gene: Cyp4d1 / 31188
• FlyBaseID: FBgn0005670
• Length: 512
• Species: Drosophila melanogaster
• Sequence 2: NP_000768.1
• Gene: CYP3A5 / 1577
• HGNCID: 2638
• Length: 502
• Species: Homo sapiens
• Alignment Length: 537
• Identity: 150/537 - (27%)
• Similarity: 252/537 - (46%)
• Gaps: 88/537 - (16%)

  Fly     8 ILASALFVGLLLY----HLKFKRLIDLISYMPGPPVLPLVGHGHHF---IGKPPHEMVKKIFEFM 65
            :|.:...|.|.||    |..||||     .:|||..|||:|:...:   :.|...|..||..:..
Human    13 LLLAVSLVLLYLYGTRTHGLFKRL-----GIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMW 72

  Fly    66 ETY---------SKDQVLKVWLGPELNVLMGNPKDVEVVLGTLRFNDKAGEYKALEPWLKEGLLV 121
            .||         :...|::..|..|...:..|.:.    ||.:.|             :|..:.:
Human    73 GTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRS----LGPVGF-------------MKSAISL 120

  Fly   122 SRGRKWHKRRKIITPAF-------HFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWI 179
            :...:|.:.|.:::|.|       .|.|:.|:.:|       |:||:.::..|  ....:|.|..
Human   121 AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDV-------LVRNLRREAEK--GKPVTLKDIF 176

  Fly   180 NLCTMDTICETAMGVSINAQSNADSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKA 244
            ...:||.|..|:.||:|::.:|....:|::.|..      ..|..|....|:.:|.|......:|
Human   177 GAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKF------LKFGFLDPLFLSIILFPFLTPVFEA 235

  Fly   245 LNV------LHQFTEKIIVQRREELIREGSSQESSNDDADVGAKRKMAFLDILLQS-----TVDE 298
            |||      ...|..|.:.:.::..:         ||.    .|.::.||.:::.|     |...
Human   236 LNVSLFPKDTINFLSKSVNRMKKSRL---------NDK----QKHRLDFLQLMIDSQNSKETESH 287

  Fly   299 RPLSNLDIREEVDTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELL 363
            :.||:|::..:...|:|.|::||||.|.|..|.:||||:.|:|..:||.:|:.|  ..|.:|:.:
Human   288 KALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPN--KAPPTYDAV 350

  Fly   364 NQLHYVDLCVKETLRMYPSVPLLGRKVLEDCEINGKLIPAGTNIGISPLYLGRREELFSEPNIFK 428
            .|:.|:|:.|.||||::|....|.|...:|.||||..||.|:.:.|....|....:.::||..|:
Human   351 VQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFR 415

  Fly   429 PERFDVVTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEPPVLIA 493
            ||||.  ...:.::||.|.||..|||||||.:||::.:|..:..||:::......::..|..|..
Human   416 PERFS--KKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDT 478

  Fly   494 ELILRTKEPLMFKVRER 510
            :.:|:.::|::.||..|
Human   479 QGLLQPEKPIVLKVDSR 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	CYP4	73..504	CDD:410721	124/448 (28%)
CYP3A5	NP_000768.1	CYP3A	67..491	CDD:410743	127/472 (27%)