Protein Alignment Cyp4d1 and CYP3A7

DIOPT Version :9

• Sequence 1: NP_476907.2
• Gene: Cyp4d1 / 31188
• FlyBaseID: FBgn0005670
• Length: 512
• Species: Drosophila melanogaster
• Sequence 2: NP_000756.3
• Gene: CYP3A7 / 1551
• HGNCID: 2640
• Length: 503
• Species: Homo sapiens
• Alignment Length: 541
• Identity: 156/541 - (28%)
• Similarity: 256/541 - (47%)
• Gaps: 96/541 - (17%)

  Fly     8 ILASALFVGLLLY----HLKFKRLIDLISYMPGPPVLPLVGHGHHFIGKPPHEMVKKIFEF-MET 67
            :||.:|.: |.||    |..||:|     .:|||..||.:|:...|        .|..:.| ||.
Human    14 LLAVSLIL-LYLYGTRTHGLFKKL-----GIPGPTPLPFLGNALSF--------RKGYWTFDMEC 64

  Fly    68 YSKDQVLKVW-----LGPELNVLMGNPKDVEVVL--------------GTLRFNDKAGEYKALEP 113
            |.|.:  |||     ..|.|.:.  :|..::.||              |.:.|
Human    65 YKKYR--KVWGIYDCQQPMLAIT--DPDMIKTVLVKECYSVFTNRRPFGPVGF------------ 113

  Fly   114 WLKEGLLVSRGRKWHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQD-------RLKHGDS 171
             :|..:.::...:|.:.|.:::|.|....|.:.|.:..:....|:||:.::       .|||...
Human   114 -MKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFG 177

  Fly   172 GFSLYDWINLCTMDTICETAMGVSINAQSNADSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTP 236
            .:|         ||.|..|:.||||::.:|....:|:..|.:      ..||.|..|.|:..:.|
Human   178 AYS---------MDVITSTSFGVSIDSLNNPQDPFVENTKKL------LRFNPLDPFVLSIKVFP 227

  Fly   237 LARAEKKALNVLHQFTEKII--VQRREELIREGSSQESSNDDADVGAKRKMAFLDILLQS----- 294
            ......:|||:. .|..|:|  :.:..:.|:||..:|:.        |.::.||.:::.|
Human   228 FLTPILEALNIT-VFPRKVISFLTKSVKQIKEGRLKETQ--------KHRVDFLQLMIDSQNSKD 283

  Fly   295 TVDERPLSNLDIREEVDTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVS 359
            :...:.||:|::..:...|:|.|::||||.|.|..|.:||||:.|:|..:||.:|:.|  ..|.:
Human   284 SETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPN--KAPPT 346

  Fly   360 YELLNQLHYVDLCVKETLRMYPSVPLLGRKVLEDCEINGKLIPAGTNIGISPLYLGRREELFSEP 424
            |:.:.||.|:|:.|.||||::|....|.|...:|.||||..||.|..:.|....|....:.::||
Human   347 YDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEP 411

  Fly   425 NIFKPERFDVVTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEPP 489
            ..|.||||. ....:.::||.|.||.:|||||||.:||::.:|..:..||:::......::..|.
Human   412 EKFLPERFS-KKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPL 475

  Fly   490 VLIAELILRTKEPLMFKVRER 510
            .|....:|.|::|::.|...|
Human   476 KLRFGGLLLTEKPIVLKAESR 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	144/505 (29%)
CYP3A7	NP_000756.3	p450	39..492	CDD:365848	144/504 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910