Protein Alignment Cyp4d1 and Cyp51

DIOPT Version :10

• Sequence 1: NP_476907.2
• Gene: Cyp4d1 / 31188
• FlyBaseID: FBgn0005670
• Length: 512
• Species: Drosophila melanogaster
• Sequence 2: NP_064394.2
• Gene: Cyp51 / 13121
• MGIID: 106040
• Length: 503
• Species: Mus musculus
• Alignment Length: 549
• Identity: 145/549 - (26%)
• Similarity: 240/549 - (43%)
• Gaps: 108/549 - (19%)

  Fly     4 VIGAILASALFVG-------LLLYHLKFKRLIDLISYMPGPP----VLPLVGHGHHFIGKPPHEM 57
            |.|..|.|.|.:.       :.|:.|....::.|.:....||    .:|.:||...| ||.|.|.
Mouse    21 VTGGNLLSTLLIACAFTLSLVYLFRLAVGHMVQLPAGAKSPPHIYSPIPFLGHAIAF-GKSPIEF 84

  Fly    58 VKKIFE-FMETYSKDQVLKVWLGPELNVLMGNPKDVEVVLGTLRFNDKAGEYKALEPWLKEGLLV 121
            ::..:| :...:|...|     |.....|:|:  |...:|    ||.|..:..|.|.:   |.|.
Mouse    85 LENAYEKYGPVFSFTMV-----GKTFTYLLGS--DAAALL----FNSKNEDLNAEEVY---GRLT 135

  Fly   122 S----RGRKWH-------KRRKIITPAF---HFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSG 172
            :    :|..:.       :::|||....   |||   |:|.:.||.:::..::.       |:||
Mouse   136 TPVFGKGVAYDVPNAIFLEQKKIIKSGLNIAHFK---QYVPIIEKEAKEYFQSW-------GESG 190

  Fly   173 -FSLYDWINLCTMDTICETAMGVSINAQSN---------ADSEYVQAVKTISMVLHKRMFNILYR 227
             .::::.::...:.|......|..|.:|.|         .|..:..|...:...|....|.   |
Mouse   191 ERNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFTHAAWLLPAWLPLPSFR---R 252

  Fly   228 FDLTYMLTPLARAEKKALNVLHQFTEKIIVQRREELIREGSSQESSNDDADVGAKRKMAFLDILL 292
            .|         ||.::..|:.:    |.|.:||       .|:|.:.|           .|..||
Mouse   253 RD---------RAHREIKNIFY----KAIQKRR-------LSKEPAED-----------ILQTLL 286

  Fly   293 QSTV-DERPLSNLDIREEVDTFMFEGHDT--TSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDK 354
            .||. |.|||::.:|...:...:..|..|  |:||.|.||  :|.....|:||:.|.::|.|.|
Mouse   287 DSTYKDGRPLTDEEISGMLIGLLLAGQHTSSTTSAWMGFF--LAKDKPLQEKCYLEQKAVCGED- 348

  Fly   355 STPVSYELLNQLHYVDLCVKETLRMYPSVPLLGRKVLEDCEINGKLIPAGTNIGISPLYLGRREE 419
            ..|::|:.|..|:.:|.|:|||||:.|.:..:.|.......:.|..||.|..:.:||....|.::
Mouse   349 LPPLTYDQLKDLNLLDRCIKETLRLRPPIMTMMRMAKTPQTVAGYTIPPGHQVCVSPTVNQRLKD 413

  Fly   420 LFSEPNIFKPERF--DVVTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFV 482
            .::|...|.|:|:  |...:.||   :||:||.||...|:|:.||.::||.|.:.:||.||.|.:
Mouse   414 SWAERLDFNPDRYLQDNPASGEK---FAYVPFGAGRHRCVGENFAYVQIKTIWSTMLRLYEFDLI 475

  Fly   483 GDSSEPPVLIAELILRTKEPLM-FKVRER 510
             :...|.|....:|...:.|:: :|.|.:
Mouse   476 -NGYFPTVNYTTMIHTPENPVIRYKRRSK 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	CYP4	73..504	CDD:410721	123/459 (27%)
Cyp51	NP_064394.2	CYP51-like	88..499	CDD:410668	125/475 (26%)