DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d1 and Cyp46a1

DIOPT Version :9

Sequence 1:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_034140.1	Gene:	Cyp46a1 / 13116	MGIID:	1341877	Length:	500	Species:	Mus musculus

Alignment Length:	534	Identity:	142/534 - (26%)
Similarity:	248/534 - (46%)	Gaps:	82/534 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ILASALFVGLLLYHLKFKRLIDLISYMPGPPVLP--LVGHGHHFIGKPPH--EMVKKIF-EFMET 67
            :|.||:.:...|......|......::|||| .|  |:||..:|..|...  .:::.:| ::.:.
Mouse     7 LLGSAVLLAFGLCCTFVHRARSRYEHIPGPP-RPSFLLGHLPYFWKKDEDCGRVLQDVFLDWAKK 70

  Fly    68 YSKDQVLKVWLGPELNVLMGNPKDVEVVLGTLRFNDKAGEYKALEPWLKEGL----LVSR---GR 125
            |.  .|::|.:..:.:|::.:|:.|:..|.:.::|..:..|:||:....|.|    |||.   ||
Mouse    71 YG--PVVRVNVFYKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECDYGR 133

  Fly   126 KWHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWINLCTMDTICET 190
             |:|:||::..||....|...:|.|.:.:..|:..:|..  ..|.:..|:.|.:...|:|.:.:.
Mouse   134 -WYKQRKVMDLAFSRSSLVSLMETFNEKAEQLVEILEAK--ADGQTPVSMQDMLTCATIDILAKA 195

  Fly   191 AMGVSINAQSNADSEYVQAVKT-ISMVLHKRMFNILYRFDLTYMLTPLARAE----KKALNVLHQ 250
            |.|:..:....|.....||||. :..:...|  |.|.:|      .|..|.:    ::::.:|.|
Mouse   196 AFGMETSMLLGAQKPLSQAVKVMLEGISASR--NTLAKF------MPGKRKQLREIRESIRLLRQ 252

  Fly   251 FTEKIIVQRREELIREG------------SSQESSNDDADVGAKRKMAFLDILLQSTVDERPLSN 303
             ..|..||||.|.::.|            .::|.:.||            ::||.:.|
Mouse   253 -VGKDWVQRRREALKRGEDMPADILTQILKAEEGAQDD------------EVLLDNFV------- 297

  Fly   304 LDIREEVDTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHY 368
                    ||...||:|:::.|.|....::..||...:...|:..|||:.:.  :.||.|.:|.|
Mouse   298 --------TFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVVGSKRH--LDYEDLGRLQY 352

  Fly   369 VDLCVKETLRMYPSVPLLG--RKVLEDCEINGKLIPAGTNIGISPLYLGRREELFSEPNIFKPER 431
            :...:||:||:||  |..|  |.:.|:..|:|..:|..|.:..|...:||.:..|.:|..|.|:|
Mouse   353 LSQVLKESLRLYP--PAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDR 415

  Fly   432 FDVVTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEPPVLIAELI 496
            |.......:   :.|.|||.|.|:||||:||.:|:|.::|.:|:..|...|  ..:...|..:..
Mouse   416 FGPGAPKPR---FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRIEFRLV--PGQRFGLQEQAT 475

  Fly   497 LRTKEPLMFKVRER 510
            |:..:|::..:|.|
Mouse   476 LKPLDPVLCTLRPR 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	135/502 (27%)
Cyp46a1	NP_034140.1	p450	34..466	CDD:278495	132/482 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910