Protein Alignment Cyp4d1 and CYP4F22

DIOPT Version :9

• Sequence 1: NP_476907.2
• Gene: Cyp4d1 / 31188
• FlyBaseID: FBgn0005670
• Length: 512
• Species: Drosophila melanogaster
• Sequence 2: NP_775754.2
• Gene: CYP4F22 / 126410
• HGNCID: 26820
• Length: 531
• Species: Homo sapiens
• Alignment Length: 524
• Identity: 175/524 - (33%)
• Similarity: 289/524 - (55%)
• Gaps: 41/524 - (7%)

  Fly     5 IGAILASALFVGLLLYH--LKFKRL-------IDLISYMPGPPVLP-LVGH-GHHFIGKPPHEMV 58
            |.|:....||:...|:.  |:|.||       ...:...|.||... |:|| |.:...:...:..
Human    21 IYAVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWLLGHLGMYLPNEAGLQDE 85

  Fly    59 KKIFEFMETYSKDQVLKVWLGPELNVL-MGNPKDVEVVLGTLRFNDKAGE--YKALEPWLKEGLL 120
            ||:.:.|.     .||.||:||.|.:| :.:|..::.:||.........:  |..|:|||.:|||
Human    86 KKVLDNMH-----HVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLL 145

  Fly   121 VSRGRKWHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDS-GFSLYDWINLCTM 184
            :|:|.||.:.|:::||||||.||..::::|.: |.|:: :.:...|..|.: ...:::.|:|.|:
Human   146 LSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQ-SADIM-HAKWRHLAEGSAVSLDMFEHISLMTL 208

  Fly   185 DTICETAMGVSINAQSNADSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKALNVLH 249
            |::.:.....:.|.|... |:|:.|:..:|.:..:|.:.:.:..|..|..:...|..::|.:::|
Human   209 DSLQKCVFSYNSNCQEKM-SDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVH 272

  Fly   250 QFTEKIIVQRREELIREGSSQESSNDDADVGAK--RKMAFLDILLQS-TVDERPLSNLDIREEVD 311
            .||.::|.:||..|.::|:       :|.:.||  :.:.|:|:||.: ..|.:.||:.|||.|.|
Human   273 HFTTEVIQERRRALRQQGA-------EAWLKAKQGKTLDFIDVLLLARDEDGKELSDEDIRAEAD 330

  Fly   312 TFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLCVKET 376
            ||||||||||||.:.:..:|:|.:||.|:||.|||:.|:...:...:.::.|.||.:..:|:||:
Human   331 TFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKES 395

  Fly   377 LRMYPSVPLLGRKVLEDCEI-NGKLIPAGTNIGISPLYLGRREELFSEPNIFKPERFDVVTTAEK 440
            ||.||.|.|:.|:..||.:: :|::||.|....:|.........::.:..::.|.||| ....::
Human   396 LRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFD-PDNPQQ 459

  Fly   441 LNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHY--EVDFVGDSSEPPVLIAELILRTKEPL 503
            .:|.||:||||||||||||.|||.|::.:||..|..:  .||........|    ||||||:..|
Human   460 RSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRRKP----ELILRTENGL 520

  Fly   504 MFKV 507
            ..||
Human   521 WLKV 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	164/483 (34%)
CYP4F22	NP_775754.2	p450	60..524	CDD:278495	164/483 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154628
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750