DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d1 and Cyp4f15

DIOPT Version :9

Sequence 1:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_598888.1	Gene:	Cyp4f15 / 106648	MGIID:	2146921	Length:	534	Species:	Mus musculus

Alignment Length:	537	Identity:	181/537 - (33%)
Similarity:	282/537 - (52%)	Gaps:	64/537 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFLVIGA--ILASALFVGLLLYHLKFKRLIDLISYMPGPPVLPLVGHGHHFIG-----KPPHEMV 58
            :.|:|||  :||..|....:.|. .:..|.|    .|.||      ..:.|:|     .|....:
Mouse    26 LLLLIGASWLLARVLTQTYIFYR-TYHHLCD----FPQPP------KWNWFLGHLGMITPTEHGL 79

  Fly    59 KKIFEFMETYSKDQVLKVWLGPELNVL-MGNPKDVEVVLGTLRFNDKAGE-------YKALEPWL 115
            |::...:.||  .|....||||.:.:: :.:|..:..||     |..|..       |..|:|||
Mouse    80 KEVTNLVATY--PQGFMTWLGPIIPIITLCHPDIIRSVL-----NASASVALKEVVFYSFLKPWL 137

  Fly   116 KEGLLVSRGRKWHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWIN 180
            .:|||:|.|.||...|:::||||||.||..:|::| ..|.:::....|.....|.:...:::.|:
Mouse   138 GDGLLLSDGDKWSSHRRMLTPAFHFNILKPYVKIF-NDSTNIMHAKWQHLASGGSARLDVFENIS 201

  Fly   181 LCTMDTICETAMGVSINAQSNADSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKAL 245
            |.|:|::.:.......|.|.| .|||:.|:..:|.::.||...:|...|..|.||...|...||.
Mouse   202 LMTLDSLQKCVFSFDSNCQEN-PSEYISAILELSALVTKRYHQLLLHIDSLYQLTCSGRRFHKAC 265

  Fly   246 NVLHQFTEKIIVQRREELIREGSSQESSNDDADVGAKRK---MAFLDILLQS-TVDERPLSNLDI 306
            :::|.||:.:|..||..|       .|.::|..:.||.|   :.|:|:||.| ..|.:.||:.||
Mouse   266 HLVHSFTDAVIQDRRRTL-------PSKHEDDVLKAKAKSKTLDFIDVLLLSKDEDGKELSDEDI 323

  Fly   307 REEVDTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYEL-------LN 364
            |.|.|||||||||||:|.|.:..||:|.|||.|::|.:|::.::.:.:||.:....       |.
Mouse   324 RAEADTFMFEGHDTTASGLSWILYNLARHPEYQERCRQEVQELLRDRESTEIECSCAVFLRDDLA 388

  Fly   365 QLHYVDLCVKETLRMYPSVPLLGRKVLEDCEI-NGKLIPAGTNIGISPLYLGRREELFSEPNIFK 428
            ||.::.:|:||:||::|.|.::.|:..:|..: :|::||.|....|:.........::.:|.::.
Mouse   389 QLPFLTMCIKESLRLHPPVTVISRRCTQDIVLPDGRVIPKGVICIINIFATHHNPTVWPDPEVYD 453

  Fly   429 PERFDVVTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEP---PV 490
            |.|||.....:: :|.|:|||||||||||||.|||.|:|..:|..|..:.|  :.|..||   |
Mouse   454 PFRFDPENIKDR-SPLAFIPFSAGPRNCIGQTFAMNEMKVALALTLLRFRV--LPDDKEPRRKP- 514

  Fly   491 LIAELILRTKEPLMFKV 507
               |||||.:..|..:|
Mouse   515 ---ELILRAEGGLWLRV 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	170/499 (34%)
Cyp4f15	NP_598888.1	p450	57..526	CDD:278495	170/497 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845205
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750