DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d1 and Cyp4v3

DIOPT Version :9

Sequence 1:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_598730.1	Gene:	Cyp4v3 / 102294	MGIID:	2142763	Length:	525	Species:	Mus musculus

Alignment Length:	512	Identity:	207/512 - (40%)
Similarity:	301/512 - (58%)	Gaps:	24/512 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GAILASALFVGLLLYHLKFKRLIDLISYMPGPPV---LPLVGHGHHFIGKPPH-EMVKKIFEFME 66
            ||.:..::|..|:.|..|::::..:      |.|   .|||||..:.  ||.: |..:::..:.|
Mouse    26 GATILISIFPMLVSYARKWQQMRSI------PSVARAYPLVGHALYM--KPNNAEFFQQLIYYTE 82

  Fly    67 TYSKDQVLKVWLGPELNVLMGNPKDVEVVLGTLRFNDKAGEYKALEPWLKEGLLVSRGRKWHKRR 131
            .:....::|:|:||...|.:...::|||:|.:.:..||:..||.|:|||..|||.|.|.||..||
Mouse    83 EFRHLPIIKLWIGPVPLVALYKAENVEVILTSSKQIDKSFLYKFLQPWLGLGLLTSTGSKWRTRR 147

  Fly   132 KIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKH-GDSGFSLYDWINLCTMDTICETAMGVS 195
            |::||.|||.||:.|::|..:.:..|:..:|    || ....|:.:.:|.||.:|.|||||||.:
Mouse   148 KMLTPTFHFTILENFLDVMNEQANILVNKLE----KHVNQEAFNCFFYITLCALDIICETAMGKN 208

  Fly   196 INAQSNADSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKALNVLHQFTEKIIVQRR 260
            |.||||.|||||:.|..:|.::::||......|||.|::....|..|:.|..||.||..:|.:|.
Mouse   209 IGAQSNNDSEYVRTVYRMSDMIYRRMKMPWLWFDLWYLVFKEGRDHKRGLKCLHTFTNNVIAERV 273

  Fly   261 EELIREGSSQESSNDDADVGAKRK-MAFLDILLQSTVDE-RPLSNLDIREEVDTFMFEGHDTTSS 323
            :|  |:.....:......:.:|.| .||||:||..|.:| ..||..|||||||||||||||||::
Mouse   274 KE--RKAEEDWTGAGRGPIPSKNKRKAFLDLLLSVTDEEGNRLSQEDIREEVDTFMFEGHDTTAA 336

  Fly   324 ALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLCVKETLRMYPSVPLLGR 388
            |:.:..|.:.|:||.|:|..:|:..|.|. ...||:.|.|.:|.|:|..:|||||::|||||..|
Mouse   337 AINWSLYLLGTNPEVQRKVDQELDEVFGR-SHRPVTLEDLKKLKYLDCVIKETLRVFPSVPLFAR 400

  Fly   389 KVLEDCEINGKLIPAGTNIGISPLYLGRREELFSEPNIFKPERFDVVTTAEKLNPYAYIPFSAGP 453
            .:.||||:.|..:..||...|.|..|.|....|.:|..|:|||| ....::..:||||:||||||
Mouse   401 SLSEDCEVGGYKVTKGTEAIIIPYALHRDPRYFPDPEEFRPERF-FPENSQGRHPYAYVPFSAGP 464

  Fly   454 RNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEPPVLIAELILRTKEPLMFKVRER 510
            |||||||||::|.|.|:|.:||.:.|: .....|...|..:||||....:..|::.|
Mouse   465 RNCIGQKFAVMEEKTILACILRQFWVE-SNQKREELGLAGDLILRPNNGIWIKLKRR 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	199/478 (42%)
Cyp4v3	NP_598730.1	p450	51..517	CDD:278495	199/476 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844928
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.850