DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d1 and cyp2p7

DIOPT Version :9

Sequence 1:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_001076518.1	Gene:	cyp2p7 / 100034406	ZFINID:	ZDB-GENE-041001-155	Length:	496	Species:	Danio rerio

Alignment Length:	500	Identity:	132/500 - (26%)
Similarity:	210/500 - (42%)	Gaps:	89/500 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LLLYHLKFKRLIDLI------SYMPGPPVLPLVGHGHHFIGKPPHEMVKKIFEFMETYSKDQVLK 75
            :|::.:.|..|.|.|      ::.|||..||.:||.||...|..|   .:..:|.|.|.|...::
Zfish    15 VLVFLVVFLFLSDYIRNKSPKNFPPGPWSLPFIGHIHHIEHKKVH---LQFLKFAEKYGKIFSIR 76

  Fly    76 VWLGPELNVLMGNPKDVEVVLGTLRFNDKAGEYKALEPWL--------KEGLLVSRGRKWHKRRK 132
            :: ||.:.||.|.....||.|       :.|:..|..|.|        .:||:.|.|.||..:|:
Zfish    77 LF-GPRIVVLDGYKLVKEVYL-------QQGDNLADRPILPMFYDITEDKGLIGSNGYKWKHQRR 133

  Fly   133 IITPAFHFKILDQFVEVFEKGSRDLLRNM-------------EQDRLKHGDSGFSLYDWINLCTM 184
            .....|         ..|..|.:.|..::             ||.|      .|.....:|....
Zfish   134 FALSTF---------RTFGLGKKSLEPSILLECSCLNDAFSNEQGR------PFDPRLLLNNAVS 183

  Fly   185 DTICETAMGVSINAQSNADSEYVQAVKTISMVLHKR--MFNILYRFDLTYMLTPLARAEKKALNV 247
            :.||..   |..|....:|..:...:|.|:.||:..  ::..||.| ..:::..|....:|...:
Zfish   184 NVICAL---VFSNRFDYSDHHFQTLLKHINEVLYLEGTVWAQLYNF-FPWLMRRLPGPHQKIFVL 244

  Fly   248 LHQFTEKIIVQRREELIREGSSQESSN--DDADVGAKRKMAFLDILLQSTVDERPLSNLDIREEV 310
            |:    |:|...||::.......:.||  |..|.    .:|.::.|...|.....:.||.|. .:
Zfish   245 LN----KVIDFVREKVNEHRVDYDPSNPRDYIDC----FLAEMEKLKDDTAAGFDVENLCIC-TL 300

  Fly   311 DTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLCVKE 375
            |.|: .|.:|||:.|.:....|..:||.|.|..:||.:|||..:...||..  :.:.|.:..:.|
Zfish   301 DLFV-AGTETTSTTLYWGLLYIIKYPEIQAKVQQEIDAVVGGSRQPSVSDR--DNMPYTNAVIHE 362

  Fly   376 TLRMYPSVPL-LGRKVLEDCEINGKLIPAGTNIGISPLYLGR-REELFSE-----PNIFKPERF- 432
            ..||...||| :.|..:||.:|....||.||      |.:|. ...||.|     |:.|.|..|
Zfish   363 IQRMGNIVPLNVFRITVEDTQIGEYSIPKGT------LVIGSLTSVLFDESEWETPHSFNPGHFL 421

  Fly   433 DVVTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHY 477
            |......:.:  |::|||.|.|.|:|::.|.:|:....:::|:.:
Zfish   422 DAEGKFRRRD--AFLPFSLGKRVCLGEQLARMELFLFFSSLLQRF 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	127/475 (27%)
cyp2p7	NP_001076518.1	p450	38..492	CDD:278495	127/476 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010