Protein Alignment wapl and wapl-1

DIOPT Version :10

• Sequence 1: NP_525042.2
• Gene: wapl / 31187
• FlyBaseID: FBgn0004655
• Length: 1741
• Species: Drosophila melanogaster
• Sequence 2: NP_500566.1
• Gene: wapl-1 / 177211
• WormBaseID: WBGene00019953
• Length: 748
• Species: Caenorhabditis elegans
• Alignment Length: 932
• Identity: 197/932 - (21%)
• Similarity: 355/932 - (38%)
• Gaps: 252/932 - (27%)

  Fly   806 LASVNNNINKIAANLSAKAEASRLAEGGVAGGAARSYGRKRKNQQVTQVLQQEPVPEEQETPDAE 870
            ::|..|:.:..:..:..|...:.||:.|:            ::.|:..|...:. |:..:|||..
 Worm     1 MSSDANSDDPFSKPIVRKRFQATLAQQGI------------EDDQLPSVRSSDS-PDVPDTPDVP 52

  Fly   871 EEQ--PTPAKIPHT---DHREHSPDHDPDPDPDELSNNSNNSSLQHDGSSSSPPPRDFKFKDKFK 930
            ..|  ..|..:|.|   .:.|...:...|.:|:.||.:|.:|..:....|:..|.|
 Worm    53 VNQLSSPPLSLPETLSEGNAETLQNLSDDSEPEMLSQSSTSSLNRRMEDSAIDPSR--------- 108

  Fly   931 RTLTLDTQGAANAG----AGGAAAAAPPESSGEQRGAVKLVISKKKGSIFKSRA-LVPSDQAEQA 990
                 .|:.:.:.|    ..|....||             |..|||..|....| ..|..:
 Worm   109 -----GTRKSQSRGFDYDPAGERTTAP-------------VQKKKKDEIDMGGAKFFPKQE---- 151

  Fly   991 TVAKRHLYKHSWDAALEANGGGTNSDASNASASGVGVAGAKDHLHHLAAGKSDGDFGDSPSSNNN 1055
               |:|:|.|.|.         |..|                          |.|.....||:|.
 Worm   152 ---KKHVYTHKWT---------TEED--------------------------DEDEKTISSSSNR 178

  Fly  1056 GSSSACSSASTLRGDSPALGKISRLAGKQGVPATSTSSDAFDLDLEPIAGELDLERSAAGASAGG 1120
            .||         |.:.||:....|    |.|.||:::..      :|:              |.|
 Worm   179 YSS---------RPNQPAVSARPR----QPVYATTSTYS------KPL--------------ASG 210

  Fly  1121 TGATTGGGGATGGGGPVRVDRKTKDYYPVVRNVKTAHQIQEIGEYQEMDDDVEYILDALQPHNPP 1185
            .|:.                         ||::|.|::::|.|||.:...|:.|||.:||..:..
 Worm   211 YGSR-------------------------VRHIKEANELRESGEYDDFKQDLVYILSSLQSSDAS 250

  Fly  1186 -ATRCLSALQLAAKCMMPAFRMHVRAHGVVTKFFKALSDANKDLSLGLCTSAIMYILSQEGLNMD 1249
             ..:||||:.||.||:.|.||..:::..:.....|||.|:.:|....|..|.::|:|:::..::.
 Worm   251 MKVKCLSAISLAKKCVSPDFRQFIKSENMTKSIVKALMDSPEDDLFALAASTVLYLLTRDFNSIK 315

  Fly  1250 LDRDSLELMINLLEADGVGGSTETGHPDRAGYDRNKQKVRELC----------EEIKAQGKGTHL 1304
            :|..||.|:..||..:......|           :|.||..:.          :|:..|.....:
 Worm   316 IDFPSLRLVSQLLRIEKFEQRPE-----------DKDKVVNMVWEVFNSYIEKQEVGGQKVSFDM 369

  Fly  1305 NVDSLTVGTLAMETLLSLTSKRAG-EWFKEDLRKLGGLEHIIKTISDFCRPVIACDTEIDWQPTL 1368
            ..:|||..:|.:|.|:.:.|:... :..|.:|..||.|:.::..|.....  :..|...|....|
 Worm   370 RKESLTPSSLIIEALVFICSRSVNDDNLKSELLNLGILQFVVAKIETNVN--LIADNADDTYSIL 432

  Fly  1369 LDNMQTVARCLRVLENVTQHNETNQRYMLTSGQGKAVETLC--------QLYRLCSRQIMLHPSD 1425
            :.|     ||.|:||:.:..::.||.::::......:.:|.        ::::|...::..:.|
 Worm   433 ILN-----RCFRILESSSVFHKKNQAFLISHRSNILISSLAKFLQVILDRVHQLAEEEVKKYIS- 491

  Fly  1426 GGGSNKEHPGVAMRELLVPVLKVLINLTHTFNEAQPSLGAELLGQRGDVVETSFRLLLLSANYIP 1490
                           .|..:.::|||::|. ||    |....|||....:..:.......|....
 Worm   492 ---------------CLALMCRLLINISHD-NE----LCCSKLGQIEGFLPNAITTFTYLAPKFG 536

  Fly  1491 DQCVFELSILVLTLLINLCMHTVPNRAAL----MQAAAPAEYVADNPPAQGSVSALQALLEYFYK 1551
            .:..:::::::.:||.||......||..|    ::...|...|.:.|       ||:|:...|..
 Worm   537 KENSYDINVMMTSLLTNLVERCNANRKVLIAQTVKMVIPGHDVEEVP-------ALEAITRLFVY 594

  Fly  1552 CEELARLVEKNTDAFLESNEKGKKKQEEVEE--------------------------------TV 1584
            .|..|::|:.:.|..|..:|.|...:||.||                                .:
 Worm   595 HESQAQIVDADLDRELAFDEGGCGDEEEEEEGGDESSDEDGVRKDGRLDRNKMDRMDQVDVVHAL 659

  Fly  1585 NNLVQRAGHHMEHTLKGSYAAILVGNLIADNELYESVVRRQLRGNSFKEIIGVLEKYHTFMNLTS 1649
            ..::.:|..|||.::..||.|:|||.::..||.:...||:.|.|.:|:.:|..|::.:.|...|.
 Worm   660 QQVMNKASAHMEGSVIASYHALLVGFVLQQNEDHLDEVRKHLPGKNFQNMISQLKRLYDFTKATM 724

  Fly  1650 SLEAAFVAHMKSTKRIIDNFKK 1671
            :......:..::.:|:|:..::
 Worm   725 AKRVESNSGFRAIERVIEYLER 746

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wapl	NP_525042.2	PHA03307	69..>436	CDD:223039
		WAPL	1152..1515	CDD:462278	87/382 (23%)
wapl-1	NP_500566.1	WAPL	217..561	CDD:462278	87/382 (23%)