DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgd and GND1

DIOPT Version :9

Sequence 1:	NP_001259175.1	Gene:	Pgd / 31185	FlyBaseID:	FBgn0004654	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	NP_012053.3	Gene:	GND1 / 856589	SGDID:	S000001226	Length:	489	Species:	Saccharomyces cerevisiae

Alignment Length:	487	Identity:	324/487 - (66%)
Similarity:	380/487 - (78%)	Gaps:	10/487 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ADIALIGLAVMGQNLILNMDEKGFVVCAYNRTVAKVKEFLANEAKDTKVIGADSLEDMVSKLKSP 69
            ||..||||||||||||||..:.||.|||||||.:||..|||||||...:|||.|:||.:||||.|
Yeast     3 ADFGLIGLAVMGQNLILNAADHGFTVCAYNRTQSKVDHFLANEAKGKSIIGATSIEDFISKLKRP 67

  Fly    70 RKVMLLVKAGSAVDDFIQQLVPLLSAGDVIIDGGNSEYQDTSRRCDELAKLGLLFVGSGVSGGEE 134
            ||||||||||:.||..|.|:||||..||:|||||||.:.|::||.:||.|.|:||||||||||||
Yeast    68 RKVMLLVKAGAPVDALINQIVPLLEKGDIIIDGGNSHFPDSNRRYEELKKKGILFVGSGVSGGEE 132

  Fly   135 GARHGPSLMPGGHEAAWPLIQPIFQAICAKADGEPCCEWVGDGGAGHFVKMVHNGIEYGDMQLIC 199
            |||:||||||||.|.|||.|:.|||:|.||:||||||||||..||||:|||||||||||||||||
Yeast   133 GARYGPSLMPGGSEEAWPHIKNIFQSISAKSDGEPCCEWVGPAGAGHYVKMVHNGIEYGDMQLIC 197

  Fly   200 EAYHIMQSLGLSAD-QMADEFGKWNSAELDSFLIEITRDILKYKDGKGY-LLERIRDTAGQKGTG 262
            |||.||:.||...| :::|.|.|||:..|||||:||||||||:.|..|. |:|:|.|||||||||
Yeast   198 EAYDIMKRLGGFTDKEISDVFAKWNNGVLDSFLVEITRDILKFDDVDGKPLVEKIMDTAGQKGTG 262

  Fly   263 KWTAIAALQYGVPVTLIGEAVFSRCLSALKDERVQASSVLKGPST-KAQVANLTKFLDDIKHALY 326
            |||||.||..|:||||||||||:|||||||:||::||.||.||.. |..|.:..:|:||::.|||
Yeast   263 KWTAINALDLGMPVTLIGEAVFARCLSALKNERIRASKVLPGPEVPKDAVKDREQFVDDLEQALY 327

  Fly   327 CAKIVSYAQGFMLMREAARENKWRLNYGGIALMWRGGCIIRSVFLGNIKDAYTSQPELSNLLLDD 391
            .:||:||||||||:||||....|:||...|||||||||||||||||.|..||..:|:|.|||.:.
Yeast   328 ASKIISYAQGFMLIREAAATYGWKLNNPAIALMWRGGCIIRSVFLGQITKAYREEPDLENLLFNK 392

  Fly   392 FFKKAIERGQDSWREVVANAFRWGIPVPALSTALSFYDGYRTAKLPANLLQAQRDYFGAHTYELL 456
            ||..|:.:.|..||:.:|.|..:|||.||.|||||||||||:.:|||||||||||||||||:.:|
Yeast   393 FFADAVTKAQSGWRKSIALATTYGIPTPAFSTALSFYDGYRSERLPANLLQAQRDYFGAHTFRVL 457

  Fly   457 GQEGQFH-------HTNWTGTGGNVSASTYQA 481
            .:....:       |.||||.|||||:|||||
Yeast   458 PECASDNLPVDKDIHINWTGHGGNVSSSTYQA 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgd	NP_001259175.1	NAD_binding_2	4..176	CDD:281445	122/170 (72%)
		PRK09287	15..471	CDD:236453	306/465 (66%)
		6PGD	180..467	CDD:278805	185/296 (63%)
GND1	NP_012053.3	gnd	4..477	CDD:273314	311/472 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346527
Domainoid	1	1.000	368	1.000	Domainoid score	I121
eggNOG	1	0.900	-	-		E1_COG0362
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68268
Inparanoid	1	1.050	638	1.000	Inparanoid score	I114
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62610
OrthoFinder	1	1.000	-	-		FOG0002705
OrthoInspector	1	1.000	-	-		otm46848
orthoMCL	1	0.900	-	-		OOG6_100975
Panther	1	1.100	-	-	LDO	PTHR11811
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4
SonicParanoid	1	1.000	-	-		X1807
TreeFam	1	0.960	-	-
	15	14.790