DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgd and GND2

DIOPT Version :9

Sequence 1:	NP_001259175.1	Gene:	Pgd / 31185	FlyBaseID:	FBgn0004654	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	NP_011772.3	Gene:	GND2 / 853172	SGDID:	S000003488	Length:	492	Species:	Saccharomyces cerevisiae

Alignment Length:	486	Identity:	310/486 - (63%)
Similarity:	376/486 - (77%)	Gaps:	10/486 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 DIALIGLAVMGQNLILNMDEKGFVVCAYNRTVAKVKEFLANEAKDTKVIGADSLEDMVSKLKSPR 70
            |:.|:||||||||||||..:.||.|.|||||.:||..|||||||...:|||.|:||:|:|||.||
Yeast     7 DLGLVGLAVMGQNLILNAADHGFTVVAYNRTQSKVDRFLANEAKGKSIIGATSIEDLVAKLKKPR 71

  Fly    71 KVMLLVKAGSAVDDFIQQLVPLLSAGDVIIDGGNSEYQDTSRRCDELAKLGLLFVGSGVSGGEEG 135
            |:|||:|||:.||..|::|||.|..||:|||||||.:.||:||.:||.|.|:|||||||||||:|
Yeast    72 KIMLLIKAGAPVDTLIKELVPHLDKGDIIIDGGNSHFPDTNRRYEELTKQGILFVGSGVSGGEDG 136

  Fly   136 ARHGPSLMPGGHEAAWPLIQPIFQAICAKADGEPCCEWVGDGGAGHFVKMVHNGIEYGDMQLICE 200
            ||.||||||||...|||.|:.|||:|.||::|||||||||..|:||:||||||||||||||||||
Yeast   137 ARFGPSLMPGGSAEAWPHIKNIFQSIAAKSNGEPCCEWVGPAGSGHYVKMVHNGIEYGDMQLICE 201

  Fly   201 AYHIMQSLGLSAD-QMADEFGKWNSAELDSFLIEITRDILKYKDGKGY-LLERIRDTAGQKGTGK 263
            ||.||:.:|...| ::::.|.|||:..||||||||||||||:.|..|. |:|:|.||||||||||
Yeast   202 AYDIMKRIGRFTDKEISEVFDKWNTGVLDSFLIEITRDILKFDDVDGKPLVEKIMDTAGQKGTGK 266

  Fly   264 WTAIAALQYGVPVTLIGEAVFSRCLSALKDERVQASSVLKGPST-KAQVANLTKFLDDIKHALYC 327
            ||||.||..|:||||||||||:|||||:||||.:||.:|.||:. |..:.:..:|:.|::.|||.
Yeast   267 WTAINALDLGMPVTLIGEAVFARCLSAIKDERKRASKLLAGPTVPKDAIHDREQFVYDLEQALYA 331

  Fly   328 AKIVSYAQGFMLMREAARENKWRLNYGGIALMWRGGCIIRSVFLGNIKDAYTSQPELSNLLLDDF 392
            :||:||||||||:|||||...|:||...||||||||||||||||..|..||...|:|.|||.::|
Yeast   332 SKIISYAQGFMLIREAARSYGWKLNNPAIALMWRGGCIIRSVFLAEITKAYRDDPDLENLLFNEF 396

  Fly   393 FKKAIERGQDSWREVVANAFRWGIPVPALSTALSFYDGYRTAKLPANLLQAQRDYFGAHTYELLG 457
            |..|:.:.|..||..:|.|..:|||.||.||||:||||||:.:|||||||||||||||||:.:|.
Yeast   397 FASAVTKAQSGWRRTIALAATYGIPTPAFSTALAFYDGYRSERLPANLLQAQRDYFGAHTFRILP 461

  Fly   458 QEGQFH-------HTNWTGTGGNVSASTYQA 481
            :....|       |.||||.|||:|:|||||
Yeast   462 ECASAHLPVDKDIHINWTGHGGNISSSTYQA 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgd	NP_001259175.1	NAD_binding_2	4..176	CDD:281445	114/169 (67%)
		PRK09287	15..471	CDD:236453	295/465 (63%)
		6PGD	180..467	CDD:278805	181/296 (61%)
GND2	NP_011772.3	gnd	7..480	CDD:273314	299/472 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346528
Domainoid	1	1.000	368	1.000	Domainoid score	I121
eggNOG	1	0.900	-	-		E1_COG0362
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68268
Inparanoid	1	1.050	638	1.000	Inparanoid score	I114
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62610
OrthoFinder	1	1.000	-	-		FOG0002705
OrthoInspector	1	1.000	-	-		otm46848
orthoMCL	1	0.900	-	-		OOG6_100975
Panther	1	1.100	-	-	O	PTHR11811
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1807
TreeFam	1	0.960	-	-
	14	13.760