DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgd and SPBC660.16

DIOPT Version :9

Sequence 1:	NP_001259175.1	Gene:	Pgd / 31185	FlyBaseID:	FBgn0004654	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	NP_595095.1	Gene:	SPBC660.16 / 2541146	PomBaseID:	SPBC660.16	Length:	492	Species:	Schizosaccharomyces pombe

Alignment Length:	488	Identity:	318/488 - (65%)
Similarity:	377/488 - (77%)	Gaps:	13/488 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ADIALIGLAVMGQNLILNMDEKGFVVCAYNRTVAKVKEFLANEAKDTKVIGADSLEDMVSKLKSP 69
            ||..||||||||||||||..:|||.||.||||.::|.||||||||...::||.|||:.|||||.|
pombe     7 ADFGLIGLAVMGQNLILNGADKGFTVCCYNRTTSRVDEFLANEAKGKSIVGAHSLEEFVSKLKKP 71

  Fly    70 RKVMLLVKAGSAVDDFIQQLVPLLSAGDVIIDGGNSEYQDTSRRCDELAKLGLLFVGSGVSGGEE 134
            |..:||||||..||..|:.|.|||..||:|:|||||.|.||:|||:||||.|:||||||||||||
pombe    72 RVCILLVKAGKPVDYLIEGLAPLLEKGDIIVDGGNSHYPDTTRRCEELAKKGILFVGSGVSGGEE 136

  Fly   135 GARHGPSLMPGGHEAAWPLIQPIFQAICAKA-DGEPCCEWVGDGGAGHFVKMVHNGIEYGDMQLI 198
            |||:||||||||:.||||.|:||||.:.||| :.||||:|||:.||||:||||||||||||||||
pombe   137 GARYGPSLMPGGNPAAWPRIKPIFQTLAAKAGNNEPCCDWVGEQGAGHYVKMVHNGIEYGDMQLI 201

  Fly   199 CEAYHIM-QSLGLSADQMADEFGKWNSAELDSFLIEITRDILKYK--DGKGYLLERIRDTAGQKG 260
            ||.|.|| :.||:|.|::||.|.|||:.:|||||||||||:|:||  |||. |:|:|.|.|||||
pombe   202 CETYDIMKRGLGMSCDEIADVFEKWNTGKLDSFLIEITRDVLRYKADDGKP-LVEKILDAAGQKG 265

  Fly   261 TGKWTAIAALQYGVPVTLIGEAVFSRCLSALKDERVQASSVLKGPSTKAQVANLTKFLDDIKHAL 325
            ||||||..||:.|.||:||.||||:||||:||.|||:||..|.||:||. ..:..:.:||::.||
pombe   266 TGKWTAQNALEMGTPVSLITEAVFARCLSSLKSERVRASKKLTGPNTKF-TGDKKQLIDDLEDAL 329

  Fly   326 YCAKIVSYAQGFMLMREAARENKWRLNYGGIALMWRGGCIIRSVFLGNIKDAYTSQPELSNLLLD 390
            |.:||:|||||||||||||:|..|:||..|||||||||||||||||.:|.:|:...|.|.::|..
pombe   330 YASKIISYAQGFMLMREAAKEYGWKLNNAGIALMWRGGCIIRSVFLKDITEAFREDPNLESILFH 394

  Fly   391 DFFKKAIERGQDSWREVVANAFRWGIPVPALSTALSFYDGYRTAKLPANLLQAQRDYFGAHTYEL 455
            .||...:|:.|..||.|||.|...||||||.||.||||||||:|.|||||||||||||||||:.:
pombe   395 PFFTNGVEKAQAGWRRVVAQAAMLGIPVPATSTGLSFYDGYRSAVLPANLLQAQRDYFGAHTFRV 459

  Fly   456 LGQEGQFH-------HTNWTGTGGNVSASTYQA 481
            |.:.....       |.||||.|||:||:||.|
pombe   460 LPEAADKSLPADKDIHINWTGHGGNISATTYDA 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgd	NP_001259175.1	NAD_binding_2	4..176	CDD:281445	119/171 (70%)
		PRK09287	15..471	CDD:236453	302/466 (65%)
		6PGD	180..467	CDD:278805	184/296 (62%)
SPBC660.16	NP_595095.1	Gnd	5..484	CDD:223439	311/478 (65%)
		NAD_binding_2	7..179	CDD:281445	119/171 (70%)
		6PGD	183..478	CDD:278805	184/296 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	362	1.000	Domainoid score	I151
eggNOG	1	0.900	-	-		E1_COG0362
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68268
Inparanoid	1	1.050	629	1.000	Inparanoid score	I141
OMA	1	1.010	-	-		QHG62610
OrthoFinder	1	1.000	-	-		FOG0002705
OrthoInspector	1	1.000	-	-		oto101520
orthoMCL	1	0.900	-	-		OOG6_100975
Panther	1	1.100	-	-	LDO	PTHR11811
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4
SonicParanoid	1	1.000	-	-		X1807
TreeFam	1	0.960	-	-
	14	13.860