DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgd and T25B9.9

DIOPT Version :9

Sequence 1:	NP_001259175.1	Gene:	Pgd / 31185	FlyBaseID:	FBgn0004654	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	NP_501998.1	Gene:	T25B9.9 / 177971	WormBaseID:	WBGene00012015	Length:	484	Species:	Caenorhabditis elegans

Alignment Length:	482	Identity:	315/482 - (65%)
Similarity:	384/482 - (79%)	Gaps:	4/482 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 QADIALIGLAVMGQNLILNMDEKGFVVCAYNRTVAKVKEFLANEAKDTKVIGADSLEDMVSKLKS 68
            :||||:||||||||||||||::.||.|||:||||..|.:|||||||.||:|||.|:|:|..|||.
Worm     3 EADIAVIGLAVMGQNLILNMNDHGFTVCAFNRTVKLVDDFLANEAKGTKIIGAHSIEEMCKKLKR 67

  Fly    69 PRKVMLLVKAGSAVDDFIQQLVPLLSAGDVIIDGGNSEYQDTSRRCDELAKLGLLFVGSGVSGGE 133
            ||:||:|:|||:.||..|..:||.|..||:|||||||||.|::||.::||..|::|||.||||||
Worm    68 PRRVMMLIKAGTPVDMMIDAIVPHLEEGDIIIDGGNSEYTDSNRRSEQLAAKGIMFVGCGVSGGE 132

  Fly   134 EGARHGPSLMPGGHEAAWPLIQPIFQAICAKADGEPCCEWVGDGGAGHFVKMVHNGIEYGDMQLI 198
            ||||.||||||||:..|||.::.|||.|.||::|||||:|||:.|:|||||||||||||||||||
Worm   133 EGARFGPSLMPGGNPKAWPHLKDIFQKIAAKSNGEPCCDWVGNAGSGHFVKMVHNGIEYGDMQLI 197

  Fly   199 CEAYHIM-QSLGLSADQMADEFGKWNSAELDSFLIEITRDILKYKDGKGY-LLERIRDTAGQKGT 261
            .||||:: :::.|:.||||:....||..||:|||||||.:||||:|.:|. ::.:|||:||||||
Worm   198 AEAYHLLSKAVELNHDQMAEVLDDWNKGELESFLIEITANILKYRDEQGEPIVPKIRDSAGQKGT 262

  Fly   262 GKWTAIAALQYGVPVTLIGEAVFSRCLSALKDERVQASSVLKGP--STKAQVANLTKFLDDIKHA 324
            ||||..|||:||:||||||||||:|||||||||||:||..|..|  |....|.:...|:..|..|
Worm   263 GKWTCFAALEYGLPVTLIGEAVFARCLSALKDERVRASKQLPRPQVSPDTVVQDKRVFIKQISKA 327

  Fly   325 LYCAKIVSYAQGFMLMREAARENKWRLNYGGIALMWRGGCIIRSVFLGNIKDAYTSQPELSNLLL 389
            ||.:|||||||||||:.||:::..|.||:|.|||||||||||||.|||:|:.|:....:||||||
Worm   328 LYASKIVSYAQGFMLLAEASKQFNWNLNFGAIALMWRGGCIIRSRFLGDIEHAFQKNKQLSNLLL 392

  Fly   390 DDFFKKAIERGQDSWREVVANAFRWGIPVPALSTALSFYDGYRTAKLPANLLQAQRDYFGAHTYE 454
            ||||.|||...|||||.||..|.|.||||||.|:||:|||||.:..:||||||||||||||||||
Worm   393 DDFFTKAITEAQDSWRVVVCAAVRLGIPVPAFSSALAFYDGYTSEVVPANLLQAQRDYFGAHTYE 457

  Fly   455 LLGQEGQFHHTNWTGTGGNVSASTYQA 481
            ||.:.|.:.|||||||||.|:::.|.|
Worm   458 LLAKPGTWVHTNWTGTGGRVTSNAYNA 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgd	NP_001259175.1	NAD_binding_2	4..176	CDD:281445	114/171 (67%)
		PRK09287	15..471	CDD:236453	300/459 (65%)
		6PGD	180..467	CDD:278805	189/290 (65%)
T25B9.9	NP_501998.1	NAD_binding_2	4..174	CDD:281445	113/169 (67%)
		PRK09287	14..474	CDD:236453	300/459 (65%)
		6PGD	179..470	CDD:278805	189/290 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167294
Domainoid	1	1.000	379	1.000	Domainoid score	I451
eggNOG	1	0.900	-	-		E1_COG0362
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68268
Inparanoid	1	1.050	638	1.000	Inparanoid score	I453
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62610
OrthoDB	1	1.010	-	-		D189465at33208
OrthoFinder	1	1.000	-	-		FOG0002705
OrthoInspector	1	1.000	-	-		oto19639
orthoMCL	1	0.900	-	-		OOG6_100975
Panther	1	1.100	-	-	LDO	PTHR11811
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4
SonicParanoid	1	1.000	-	-		X1807
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.840