DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D2hgdh and DLD3

DIOPT Version :9

Sequence 1:	NP_569982.1	Gene:	D2hgdh / 31184	FlyBaseID:	FBgn0023507	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_010843.1	Gene:	DLD3 / 856638	SGDID:	S000000797	Length:	496	Species:	Saccharomyces cerevisiae

Alignment Length:	491	Identity:	215/491 - (43%)
Similarity:	307/491 - (62%)	Gaps:	16/491 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 PIPELT-EITDNVQRG-NYATLTDKDVAHFEQLLGKNFVLT----EDLEGYNICFLKRIRGNSKL 116
            |:.:|| |....|:|. |:..|..:|:|:|..:|..:.:|.    |:|..:|..::|:.||.|.|
Yeast     6 PVAQLTAEAYPKVKRNPNFKVLDSEDLAYFRSILSNDEILNSQAPEELASFNQDWMKKYRGQSNL 70

  Fly   117 VLKPGSTAEVAAILKYCNERRLAVVPQGGNTGLVGGSVPICDEIVLSLARLNKVLSVDEVTGIAV 181
            :|.|.||.:|:.|:||||:::||||||||||.|||.|||:.|||||||..:|||...|.|:|...
Yeast    71 ILLPNSTDKVSKIMKYCNDKKLAVVPQGGNTDLVGASVPVFDEIVLSLRNMNKVRDFDPVSGTFK 135

  Fly   182 VEAGCILENFDQRAREVGLTVPLDLGAKASCHIGGNVSTNAGGVRVVRYGNLHGSVLGVEAVLAT 246
            .:||.::.:..|...:.....||||.::.:|.:||.|||||||:..:|||:|||:|||:|.||..
Yeast   136 CDAGVVMRDAHQFLHDHDHIFPLDLPSRNNCQVGGVVSTNAGGLNFLRYGSLHGNVLGLEVVLPN 200

  Fly   247 GQVLDLMSNFKKDNTGYHMKHLFIGSEGTLGVVTKLSMLCPHSSRAVNVAFIGLNSFDDVLKTFV 311
            |:::..::..:||||||.:|.||||:|||:||||.:|::.....:|:|..|.|:.:||.|.|.||
Yeast   201 GEIISNINALRKDNTGYDLKQLFIGAEGTIGVVTGVSIVAAAKPKALNAVFFGIENFDTVQKLFV 265

  Fly   312 SAKRNLGEILSSCELIDERALNTALEQFKFLNSPISG-FPFYMLIETSGSNGDHDEEKINQFIGD 375
            .||..|.||||:.|.:|..::...:|..|.|..|:.. ..||:||||||||..||:||:..|:.|
Yeast   266 KAKSELSEILSAFEFMDRGSIECTIEYLKDLPFPLENQHNFYVLIETSGSNKRHDDEKLTAFLKD 330

  Fly   376 GMERGEIQDGTVTGDPGKVQEIWKIREMVPLGLIEKSFCFKYDISLPLRDFYNIVDVMRERCGPL 440
            ..:...|.:|.:..|......:|..|:.||.........:|||:||.|:|.|::...:.||....
Yeast   331 TTDSKLISEGMMAKDKADFDRLWTWRKSVPTACNSYGGMYKYDMSLQLKDLYSVSAAVTERLNAA 395

  Fly   441 ATV---------VCGYGHLGDSNLHLNVSCEEFNGEIYKRVEPFVYEYTSKLKGSISAEHGIGFL 496
            ..:         .|||||:||.|:|||::..||..:|...:|||||||.:..||||||||||||.
Yeast   396 GLIGDAPKPVVKSCGYGHVGDGNIHLNIAVREFTKQIEDLLEPFVYEYIASKKGSISAEHGIGFH 460

  Fly   497 KKDYLHYSKDPVAIGYMREMKKLLDPNSILNPYKVL 532
            ||..|||::..:.|.:|:::|...|||.||||||.:
Yeast   461 KKGKLHYTRSDIEIRFMKDIKNHYDPNGILNPYKYI 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D2hgdh	NP_569982.1	GlcD	85..532	CDD:223354	205/460 (45%)
		FAD_binding_4	115..252	CDD:279851	70/136 (51%)
		FAD-oxidase_C	291..531	CDD:280983	105/249 (42%)
DLD3	NP_010843.1	GlcD	34..496	CDD:223354	205/461 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I428
eggNOG	1	0.900	-	-		E1_COG0277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	458	1.000	Inparanoid score	I239
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62883
OrthoFinder	1	1.000	-	-		FOG0003549
OrthoInspector	1	1.000	-	-		otm46844
orthoMCL	1	0.900	-	-		OOG6_100306
Panther	1	1.100	-	-	O	PTHR43716
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2425
TreeFam	1	0.960	-	-
	11	10.830