DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment D2hgdh and AGPS

DIOPT Version :9

Sequence 1:	NP_569982.1	Gene:	D2hgdh / 31184	FlyBaseID:	FBgn0023507	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_003650.1	Gene:	AGPS / 8540	HGNCID:	327	Length:	658	Species:	Homo sapiens

Alignment Length:	656	Identity:	152/656 - (23%)
Similarity:	245/656 - (37%)	Gaps:	166/656 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RRLASAGATTLMR-RPITTTTITTTSRTALAATYPAFATTVRTMAG------------------- 54
            |||.......|.| |...:|......|.|.|||....||.....:|
Human    36 RRLRVLSGHLLGRPREALSTNECKARRAASAATAAPTATPAAQESGTIPKKRQEVMKWNGWGYND 100

  Fly    55 --------------------SGAPIPELTEITDNVQRGNY-------ATLTDKDVAHFEQLLGKN 92
                                ||..:|...|...|....|.       |:|...|..  ..::.::
Human   101 SKFIFNKKGQIELTGKRYPLSGMGLPTFKEWIQNTLGVNVEHKTTSKASLNPSDTP--PSVVNED 163

  Fly    93 FVLTEDLEGYNICFLK-------RIRGN----------------SKLVLKPGSTAEVAAILKYCN 134
            |:  .||:..||.:.:       |..|:                ..:||.|....:|..|:....
Human   164 FL--HDLKETNISYSQEADDRVFRAHGHCLHEIFLLREGMFERIPDIVLWPTCHDDVVKIVNLAC 226

  Fly   135 ERRLAVVPQGGNTGLVGGSVPICDE----IVLSLARLNKVLSVDEVTGIAVVEAGCILENFDQRA 195
            :..|.::|.||.|.:..|.:...||    |.|..:::|::|.|||....|.||||...:..:::.
Human   227 KYNLCIIPIGGGTSVSYGLMCPADETRTIISLDTSQMNRILWVDENNLTAHVEAGITGQELERQL 291

  Fly   196 REVGLTVPLDLGAKASCHIGGNVSTNAGGVRVVRYGNLHGSVLGVEAVLATGQVLDLMSNFKKDN 260
            :|.|.....:..:.....:||.|||.|.|::...|||:...|:.::.|...| :::......:.:
Human   292 KESGYCTGHEPDSLEFSTVGGWVSTRASGMKKNIYGNIEDLVVHIKMVTPRG-IIEKSCQGPRMS 355

  Fly   261 TGYHMKHLFIGSEGTLGVVTKLSML---CPHSSRAVNVAFIGLNSFDDVLKTFVSAKRNLGEILS 322
            ||..:.|..:||||||||:|:.::.   .|...:..:|||.........|:..  ||:....  :
Human   356 TGPDIHHFIMGSEGTLGVITEATIKIRPVPEYQKYGSVAFPNFEQGVACLREI--AKQRCAP--A 416

  Fly   323 SCELIDER------ALNTALEQF---------KFLNSPISGF-PFYMLIETSGSNGDHDEEKI-- 369
            |..|:|.:      ||...:...         ||..:...|| |..:.:.|....|  |.||:
Human   417 SIRLMDNKQFQFGHALKPQVSSIFTSFLDGLKKFYITKFKGFDPNQLSVATLLFEG--DREKVLQ 479

  Fly   370 --NQFIGDGMERGEIQDGTVTGDPGKV--QEIWKIREM-VPLGLIEKSFCFKYDISLPLRDFYNI 429
              .|......:.|.:..|...|..|.:  ..|..||:: :...::.:||    :.|.|   :..:
Human   480 HEKQVYDIAAKFGGLAAGEDNGQRGYLLTYVIAYIRDLALEYYVLGESF----ETSAP---WDRV 537

  Fly   430 VDVMR---ER----C-------GPLATV---------VCGYGHLGDSNLHLNVSCEEFNGEIYKR 471
            ||:.|   ||    |       .|.:|.         .|.|.:..            ||   |:.
Human   538 VDLCRNVKERITRECKEKGVQFAPFSTCRVTQTYDAGACIYFYFA------------FN---YRG 587

  Fly   472 V-EPF-VYEYTSKLK--------GSISAEHGIGFLKKDYLHYSKDPVAIGYMREMKKLLDPNSIL 526
            : :|. |:|.|....        ||:|..||:|.|:|.:|..|...|..|.::.:|:.:|||:|.
Human   588 ISDPLTVFEQTEAAAREEILANGGSLSHHHGVGKLRKQWLKESISDVGFGMLKSVKEYVDPNNIF 652

  Fly   527 NPYKVL 532
            ....:|
Human   653 GNRNLL 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D2hgdh	NP_569982.1	GlcD	85..532	CDD:223354	127/532 (24%)
		FAD_binding_4	115..252	CDD:279851	40/140 (29%)
		FAD-oxidase_C	291..531	CDD:280983	67/295 (23%)
AGPS	NP_003650.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..86		7/22 (32%)
		GlcD	200..652	CDD:223354	119/480 (25%)
		FAD_binding_4	206..347	CDD:279851	40/141 (28%)
		FAD-oxidase_C	385..657	CDD:280983	68/299 (23%)
		Important for enzyme activity. /evidence=ECO:0000250\|UniProtKB:P97275	615..617		0/1 (0%)
		Important for enzyme activity. /evidence=ECO:0000250\|UniProtKB:P97275	654..658		0/3 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810