Protein Alignment D2hgdh and DLD1

DIOPT Version :10

• Sequence 1: NP_569982.1
• Gene: D2hgdh / 31184
• FlyBaseID: FBgn0023507
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: NP_010107.1
• Gene: DLD1 / 851380
• SGDID: S000002333
• Length: 587
• Species: Saccharomyces cerevisiae
• Alignment Length: 501
• Identity: 126/501 - (25%)
• Similarity: 218/501 - (43%)
• Gaps: 82/501 - (16%)

  Fly    79 DKDVAHFEQLLG---KNFV-LTEDLEGYNICFLKRIRGN----SKLVLKPGSTAEVAAILKYCNE 135
            ||.|...:|:||   :|:. ...||:.::..:......:    .:::|.|.:|.||:.|||.|::
Yeast   108 DKVVEDLKQVLGNKPENYSDAKSDLDAHSDTYFNTHHPSPEQRPRIILFPHTTEEVSKILKICHD 172

  Fly   136 RRLAVVPQGGNTGLVGGSVP--ICDEIVLSLAR-LNKVLSVDEVTGIAVVEAGCILENFDQRARE 197
            ..:.|||..|.|.|.|..:|  |.|.|.:.|:: :|.|:..|::.....|:||...|:.:....:
Yeast   173 NNMPVVPFSGGTSLEGHFLPTRIGDTITVDLSKFMNNVVKFDKLDLDITVQAGLPWEDLNDYLSD 237

  Fly   198 VGLTVPLDLGAKASCHIGGNVSTNAGGVRVVRYGNLHGSVLGVEAVLATGQVLDLMSNFKKDNTG 262
            .||....|.|..|  .|||.::.:..|....|||.:..:::.:..||..|.::......:|.:.|
Yeast   238 HGLMFGCDPGPGA--QIGGCIANSCSGTNAYRYGTMKENIINMTIVLPDGTIVKTKKRPRKSSAG 300

  Fly   263 YHMKHLFIGSEGTLGVVTKLSMLCPHSSRAVNVAFIGLNSFDDVLKTFVSAKRNL---GEILSSC 324
            |::..||:|||||||:||:.::.|....:|..||.:   || |.:|...:...||   |..|::.
Yeast   301 YNLNGLFVGSEGTLGIVTEATVKCHVKPKAETVAVV---SF-DTIKDAAACASNLTQSGIHLNAM 361

  Fly   325 ELIDERALNTALEQFKFLNSPISGFPFYMLIETSGSNGDHD-EEKINQFIGDGMERGEIQDGTV- 387
            ||:||..:.                    ||..|.|....| .||...|...|.....|.:..|
Yeast   362 ELLDENMMK--------------------LINASESTDRCDWVEKPTMFFKIGGRSPNIVNALVD 406

  Fly   388 ----------------TGDPGKVQEIWKIREMVPLGLIE-------KSFCFKYDISLPLRDFYNI 429
                            ..|..:..|:|:.|::....:::       .:..:..|:::|:..|..:
Yeast   407 EVKAVAQLNHCNSFQFAKDDDEKLELWEARKVALWSVLDADKSKDKSAKIWTTDVAVPVSQFDKV 471

  Fly   430 VDVMRERCGPLATVVCGYGHLGDSNLHLNV---------SCEEFNGEIYKRVEPFVYEYTSKLKG 485
            :...::.......:....||.||.|.|..:         :|.:....:.||        ....:|
Yeast   472 IHETKKDMQASKLINAIVGHAGDGNFHAFIVYRTPEEHETCSQLVDRMVKR--------ALNAEG 528

  Fly   486 SISAEHGIGFLKKDYLHYSKDPVAIGYMREMKKLLDPNSILNPYKV 531
            :.:.|||:|..|::||........:..||::|..:||..|:||.|:
Yeast   529 TCTGEHGVGIGKREYLLEELGEAPVDLMRKIKLAIDPKRIMNPDKI 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
D2hgdh	NP_569982.1	GlcD	77..533	CDD:440046	126/501 (25%)
DLD1	NP_010107.1	GlcD	110..578	CDD:440046	124/499 (25%)