DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D2hgdh and DLD2

DIOPT Version :9

Sequence 1:	NP_569982.1	Gene:	D2hgdh / 31184	FlyBaseID:	FBgn0023507	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_010103.1	Gene:	DLD2 / 851376	SGDID:	S000002337	Length:	530	Species:	Saccharomyces cerevisiae

Alignment Length:	503	Identity:	236/503 - (46%)
Similarity:	328/503 - (65%)	Gaps:	23/503 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 FATTVRTMAGSGAPIPELTEITDNVQRG-NYATLTDKDVAHFEQLLGKNFVL----TEDLEGYNI 104
            ::|.::|...|        |...:|.|. .:..||..|:.:|:.:|.:..:|    :|||..||.
Yeast    36 YSTKIQTRLTS--------ENYPDVHRDPRFKKLTSDDLNYFKSILSEQEILRASESEDLSFYNE 92

  Fly   105 CFLKRIRGNSKLVLKPGSTAEVAAILKYCNERRLAVVPQGGNTGLVGGSVPICDEIVLSLARLNK 169
            .::::.:|.|||||:|.|..:|:.||.|||:.::||||||||||||||||||.||::||||.|||
Yeast    93 DWMRKYKGQSKLVLRPKSVEKVSLILNYCNDEKIAVVPQGGNTGLVGGSVPIFDELILSLANLNK 157

  Fly   170 VLSVDEVTGIAVVEAGCILENFDQRAREVGLTVPLDLGAKASCHIGGNVSTNAGGVRVVRYGNLH 234
            :...|.|:||...:||.||||.:....|.....|||||||.|||:||.|:|||||:|::|||:||
Yeast   158 IRDFDPVSGILKCDAGVILENANNYVMEQNYMFPLDLGAKGSCHVGGVVATNAGGLRLLRYGSLH 222

  Fly   235 GSVLGVEAVLATGQVLDLMSNFKKDNTGYHMKHLFIGSEGTLGVVTKLSMLCPHSSRAVNVAFIG 299
            |||||:|.|:..||:::.|.:.:||||||.:|.||||||||:|::|.:|:|.....:|.||:::.
Yeast   223 GSVLGLEVVMPNGQIVNSMHSMRKDNTGYDLKQLFIGSEGTIGIITGVSILTVPKPKAFNVSYLS 287

  Fly   300 LNSFDDVLKTFVSAKRNLGEILSSCELIDERALNTALEQFKFLNSPISG-FPFYMLIETSGSNGD 363
            :.||:||.|.||.|::.|.||||:.|.:|.::...|..|.|....|:.. .|||:||||||||.|
Yeast   288 VESFEDVQKVFVRARQELSEILSAFEFMDAKSQVLAKSQLKDAAFPLEDEHPFYILIETSGSNKD 352

  Fly   364 HDEEKINQFIGDGMERGEIQDGTVTGDPGKVQEIWKIREMVPLGLIEKSFCFKYDISLPLRDFYN 428
            ||:.|:..|:.:.||.|.:.||.|..|..::|.:||.|||:|.........:|||:||||:|.|:
Yeast   353 HDDSKLETFLENVMEEGIVTDGVVAQDETELQNLWKWREMIPEASQANGGVYKYDVSLPLKDLYS 417

  Fly   429 IVDVMRERCGPLATV---------VCGYGHLGDSNLHLNVSCEEFNGEIYKRVEPFVYEYTSKLK 484
            :|:....|......|         ..||||:||.||||||:..|:|..|.|.:||||||:.|...
Yeast   418 LVEATNARLSEAELVGDSPKPVVGAIGYGHVGDGNLHLNVAVREYNKNIEKTLEPFVYEFVSSKH 482

  Fly   485 GSISAEHGIGFLKKDYLHYSKDPVAIGYMREMKKLLDPNSILNPYKVL 532
            ||:|||||:||.||:|:.|||.|..:..|:::|...|||.||||||.:
Yeast   483 GSVSAEHGLGFQKKNYIGYSKSPEEVKMMKDLKVHYDPNGILNPYKYI 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D2hgdh	NP_569982.1	GlcD	85..532	CDD:223354	227/460 (49%)
		FAD_binding_4	115..252	CDD:279851	83/136 (61%)
		FAD-oxidase_C	291..531	CDD:280983	113/249 (45%)
DLD2	NP_010103.1	GlcD	68..530	CDD:223354	227/461 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344202
Domainoid	1	1.000	226	1.000	Domainoid score	I428
eggNOG	1	0.900	-	-		E1_COG0277
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5534
Inparanoid	1	1.050	458	1.000	Inparanoid score	I239
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62883
OrthoFinder	1	1.000	-	-		FOG0003549
OrthoInspector	1	1.000	-	-		otm46844
orthoMCL	1	0.900	-	-		OOG6_100306
Panther	1	1.100	-	-	LDO	PTHR43716
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1958
SonicParanoid	1	1.000	-	-		X2425
TreeFam	1	0.960	-	-
	15	14.790