DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment D2hgdh and D2HGDH

DIOPT Version :9

Sequence 1:	NP_569982.1	Gene:	D2hgdh / 31184	FlyBaseID:	FBgn0023507	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001320151.1	Gene:	D2HGDH / 829792	AraportID:	AT4G36400	Length:	559	Species:	Arabidopsis thaliana

Alignment Length:	468	Identity:	240/468 - (51%)
Similarity:	332/468 - (70%)	Gaps:	5/468 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 VQRGN-YATLTDKDVAHFEQLLGKNFVL--TEDLEGYNICFLKRIRGNSKLVLKPGSTAEVAAIL 130
            :||.. :::|..|||::|:::||:..|:  .|.||..|..::.:.:|:|||:|.|.:|.||:.||
plant    86 IQRNPLFSSLDSKDVSYFKEILGEKNVVEDKERLETANTDWMHKYKGSSKLMLLPKNTQEVSQIL 150

  Fly   131 KYCNERRLAVVPQGGNTGLVGGSVPICDEIVLSLARLNKVLSVDEVTGIAVVEAGCILENFDQRA 195
            :||:.||||||||||||||||||||:.||:::::..:||:||.|||:|:.|.||||||||.....
plant   151 EYCDSRRLAVVPQGGNTGLVGGSVPVFDEVIVNVGLMNKILSFDEVSGVLVCEAGCILENLATFL 215

  Fly   196 REVGLTVPLDLGAKASCHIGGNVSTNAGGVRVVRYGNLHGSVLGVEAVLATGQVLDLMSNFKKDN 260
            ...|..:|||||||.||||||||||||||:|::|||:|||:|||:|||.|.|.|||::...:|||
plant   216 DTKGFIMPLDLGAKGSCHIGGNVSTNAGGLRLIRYGSLHGTVLGLEAVTANGNVLDMLGTLRKDN 280

  Fly   261 TGYHMKHLFIGSEGTLGVVTKLSMLCPHSSRAVNVAFIGLNSFDDVLKTFVSAKRNLGEILSSCE 325
            |||.:|||||||||:||:|||:|:|......:||:|||....:....|..|.||||||||||:.|
plant   281 TGYDLKHLFIGSEGSLGIVTKVSILTQPKLSSVNLAFIACKDYLSCQKLLVEAKRNLGEILSAFE 345

  Fly   326 LIDERALNTALEQFKFLNSPISGFP-FYMLIETSGSNGDHDEEKINQFIGDGMERGEIQDGTVTG 389
            .:|..:::..|.....:.:|:|... ||:||||:||:..:|.||:..|:...:|:|.:.||.:..
plant   346 FLDNNSMDLVLNHLDGVRNPVSSSENFYILIETTGSDETNDREKLEAFLLKSLEKGLVSDGVIAQ 410

  Fly   390 DPGKVQEIWKIREMVPLGLIEKSFCFKYDISLPLRDFYNIVDVMRERCGPLATVVCGYGHLGDSN 454
            |..:....|:|||.:...|.:....:|||:|||:.:.||||:.:|.|.|.||.|: |||||||.|
plant   411 DINQASSFWRIREGITEALQKAGAVYKYDLSLPVEEIYNIVNDLRGRLGDLANVM-GYGHLGDGN 474

  Fly   455 LHLNVSCEEFNGEIYKRVEPFVYEYTSKLKGSISAEHGIGFLKKDYLHYSKDPVAIGYMREMKKL 519
            ||||:|..|:|.::...:||:|||:|||.:||||||||:|.:|.:.:.|||.|..:..|..:|||
plant   475 LHLNISAAEYNDKLLGLIEPYVYEWTSKHRGSISAEHGLGVMKANEIFYSKSPETVALMASIKKL 539

  Fly   520 LDPNSILNPYKVL 532
            |||..||||||||
plant   540 LDPKGILNPYKVL 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D2hgdh	NP_569982.1	GlcD	85..532	CDD:223354	232/449 (52%)
		FAD_binding_4	115..252	CDD:279851	89/136 (65%)
		FAD-oxidase_C	291..531	CDD:280983	109/240 (45%)
D2HGDH	NP_001320151.1	GlcD	102..554	CDD:223354	234/452 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	224	1.000	Domainoid score	I698
eggNOG	1	0.900	-	-		E1_COG0277
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5534
Inparanoid	1	1.050	479	1.000	Inparanoid score	I338
OMA	1	1.010	-	-		QHG62883
OrthoDB	1	1.010	-	-		D515900at2759
OrthoFinder	1	1.000	-	-		FOG0003549
OrthoInspector	1	1.000	-	-		oto4220
orthoMCL	1	0.900	-	-		OOG6_100306
Panther	1	1.100	-	-	LDO	PTHR43716
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2425
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840