Protein Alignment D2hgdh and GLDH

DIOPT Version :10

• Sequence 1: NP_569982.1
• Gene: D2hgdh / 31184
• FlyBaseID: FBgn0023507
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: NP_190376.1
• Gene: GLDH / 823948
• AraportID: AT3G47930
• Length: 610
• Species: Arabidopsis thaliana
• Alignment Length: 647
• Identity: 123/647 - (19%)
• Similarity: 212/647 - (32%)
• Gaps: 212/647 - (32%)

  Fly    10 RRLASAGATTLMRRPITTTTITTTSRTALAATYPAFATTVRTMAGSGA------PIPELTEITDN 68
            |.|.:.|.|.....|...........||..|.:..:|........||.      |.||..: ...
plant    33 RTLCTTGQTLTPPPPPPPRPPPPPPATASEAQFRKYAGYAALAIFSGVATYFSFPFPENAK-HKK 96

  Fly    69 VQRGNYATLTDKDVAHFEQLLGKNFVLTEDLEGYNICFLKRIRGNSKLVLKPGSTAEVAAILKYC 133
            .|...||.|.: |:.......|.:.|.|.:..                  :|.:.|::.|::|..
plant    97 AQIFRYAPLPE-DLHTVSNWSGTHEVQTRNFN------------------QPENLADLEALVKES 142

  Fly   134 NERRLAVVPQGGNTGLVGGSVPICDEIVLSLARLNKVLSVDEVTGIAVVEAGCILENFDQRAREV 198
            :|::|.:.|.|  :||....:.:....:::||.::|||.||:......|:||..::......::.
plant   143 HEKKLRIRPVG--SGLSPNGIGLSRSGMVNLALMDKVLEVDKEKKRVTVQAGIRVQQLVDAIKDY 205

  Fly   199 GLTVPLDLGAKASCHIGGNVSTNAGGVRVVRYGNLHGSVLGVEAVLATGQVLDLMSNFKKDNTGY 263
            |||:. :..:.....|||.:...|.|.. .|...:...|:.::.|......::|  :.:||...:
plant   206 GLTLQ-NFASIREQQIGGIIQVGAHGTG-ARLPPIDEQVISMKLVTPAKGTIEL--SREKDPELF 266

  Fly   264 HMKHLFIGSEGTLGVVTKLSMLCPHSSRAVNVAFIGLNSFDDVLKTFVSAKRNLGEILSSCELID 328
            |:....:|.   ||||.::::.|......|.             .|:||   ||.||..     :
plant   267 HLARCGLGG---LGVVAEVTLQCVARHELVE-------------HTYVS---NLQEIKK-----N 307

  Fly   329 ERALNTALEQFKFLNSPI---------------SGFP------------------------FYML 354
            .:.|.:|.:..|:|..|.               ||.|                        .|.:
plant   308 HKKLLSANKHVKYLYIPYTDTVVVVTCNPVSKWSGPPKDKPKYTTDEAVQHVRDLYRESIVKYRV 372

  Fly   355 IETSGSNGDHDEEKINQFIGDGMERGEIQDGTVTGDP------GKVQ----EIWKIREMVPLGLI 409
            .::...:.|..|..|.:     :...|::|..:..||      .||.    |.||..|...:|..
plant   373 QDSGKKSPDSSEPDIQE-----LSFTELRDKLLALDPLNDVHVAKVNQAEAEFWKKSEGYRVGWS 432

  Fly   410 EKSFCFKYDISLPLRDFYNIVDV-----MRERCGPLATVVCGYGHLGDSNLHLNVSCE--EFNGE 467
            ::...|               |.     :.|.|.|..|:.             |.|.:  |:..|
plant   433 DEILGF---------------DCGGQQWVSESCFPAGTLA-------------NPSMKDLEYIEE 469

  Fly   468 IYKRVE--------PFVYEYTSKLKGSISAEHG---------IGFL----------KKD------ 499
            :.|.:|        |....:|::.|..||....         :|.:          :||
plant   470 LKKLIEKEAIPAPAPIEQRWTARSKSPISPAFSTSEDDIFSWVGIIMYLPTADPRQRKDITDEFF 534

  Fly   500 ----------------YLHYSKDPV------------------AIGYMREMKKLLDPNSILN 527
                            |.|::|..:                  .:....:.::.||||.||:
plant   535 HYRHLTQKQLWDQFSAYEHWAKIEIPKDKEELEALQARIRKRFPVDAYNKARRELDPNRILS 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
D2hgdh	NP_569982.1	GlcD	77..533	CDD:440046	106/574 (18%)
GLDH	NP_190376.1	GLDHase	62..604	CDD:130737	116/618 (19%)