DRSC/TRiP Functional Genomics Resources

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Protein Alignment D2hgdh and D2HGDH

DIOPT Version :9

Sequence 1:NP_569982.1 Gene:D2hgdh / 31184 FlyBaseID:FBgn0023507 Length:533 Species:Drosophila melanogaster
Sequence 2:XP_011510036.1 Gene:D2HGDH / 728294 HGNCID:28358 Length:561 Species:Homo sapiens


Alignment Length:518 Identity:244/518 - (47%)
Similarity:333/518 - (64%) Gaps:42/518 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 GAPIPELTEITDNVQRGNYATLTDKDVAHFEQLLGKNFVL-TEDLEGYNICFLKRIRGNSKLVLK 119
            |.|...||.....|:|..::|::.:|:|.||:::....|. .|.|:..|:.:|:.:||.||::|:
Human    41 GTPEVPLTRERYPVRRLPFSTVSKQDLAAFERIVPGGVVTDPEALQAPNVDWLRTLRGCSKVLLR 105

  Fly   120 PGSTAEVAAILKYCNERRLAVVPQGGNTGLVGGSVPICDEIVLSLARLNKVLSVDEVTGIAVVEA 184
            |.::.||:.||::|:||.|||.|||||||:||||||:.|||:||.||:|:|||...|:||.|.:|
Human   106 PRTSEEVSHILRHCHERNLAVNPQGGNTGMVGGSVPVFDEIILSTARMNRVLSFHSVSGILVCQA 170

  Fly   185 GCILENFDQRAREVGLTVPLDLGAKASCHIGGNVSTNAGGVRVVRYGNLHGSVLGVEAVLATGQV 249
            ||:||...:...|....:|||||||.||||||||:|||||:|.:|||:|||:|||:|.|||.|.|
Human   171 GCVLEELSRYVEERDFIMPLDLGAKGSCHIGGNVATNAGGLRFLRYGSLHGTVLGLEVVLADGTV 235

  Fly   250 LDLMSNFKKDNTGYHMKHLFIGSEGTLGVVTKLSMLCPHSSRAVNVAFI---------------- 298
            ||.:::.:||||||.:|.||||||||||::|.:|:|||...|||||||:                
Human   236 LDCLTSLRKDNTGYDLKQLFIGSEGTLGIITTVSILCPPKPRAVNVAFLVTCVPPACGPGSPRPA 300

  Fly   299 ----------GLNSFDDVLKTFVSAKRNLGEILSSCELIDERALNTALEQFKFLNSPISGFPFYM 353
                      |...|.:||:||.:.|..||||||:.|.:|...:. .:.:...|.||:...|||:
Human   301 RLPHPALRTPGCPGFAEVLQTFSTCKGMLGEILSAFEFMDAVCMQ-LVGRHLHLASPVQESPFYV 364

  Fly   354 LIETSGSNGDHDEEKINQFIGDGMERGEIQDGTVTGDPGKVQEIWKIREMVPLGLIEKSFCFKYD 418
            ||||||||..||.||:..|:...:..|.:.|||:..|..||:.:|.:||.:...|....:.:|||
Human   365 LIETSGSNAGHDAEKLGHFLEHALGSGLVTDGTMATDQRKVKMLWALRERITEALSRDGYVYKYD 429

  Fly   419 ISLPLRDFYNIVDVMRERCGPLATVVCGYGHL--------------GDSNLHLNVSCEEFNGEIY 469
            :|||:...|:||..:|.|.||.|..|.|||||              ||.||||||:.|.|:..:.
Human   430 LSLPVERLYDIVTDLRARLGPHAKHVVGYGHLGAGDTDWKTVWTLPGDGNLHLNVTAEAFSPSLL 494

  Fly   470 KRVEPFVYEYTSKLKGSISAEHGIGFLKKDYLHYSKDPVAIGYMREMKKLLDPNSILNPYKVL 532
            ..:||.|||:|:..:||:|||||:||.|:|.|.|||.|.|:..|:::|.||||..||||||.|
Human   495 AALEPHVYEWTAGQQGSVSAEHGVGFRKRDVLGYSKPPGALQLMQQLKALLDPKGILNPYKTL 557

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
D2hgdhNP_569982.1 GlcD 85..532 CDD:223354 234/487 (48%)
FAD_binding_4 115..252 CDD:279851 84/136 (62%)
FAD-oxidase_C 291..531 CDD:280983 116/279 (42%)
D2HGDHXP_011510036.1 GlcD 69..560 CDD:223354 235/490 (48%)
FAD_binding_4 101..238 CDD:279851 84/136 (62%)
FAD-oxidase_C 311..555 CDD:280983 108/244 (44%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148518
Domainoid 1 1.000 230 1.000 Domainoid score I2462
eggNOG 1 0.900 - - E1_COG0277
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H5534
Inparanoid 1 1.050 480 1.000 Inparanoid score I1476
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG62883
OrthoDB 1 1.010 - - D216115at33208
OrthoFinder 1 1.000 - - FOG0003549
OrthoInspector 1 1.000 - - oto90406
orthoMCL 1 0.900 - - OOG6_100306
Panther 1 1.100 - - LDO PTHR43716
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1958
SonicParanoid 1 1.000 - - X2425
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.800

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