DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D2hgdh and d2hgdh

DIOPT Version :9

Sequence 1:	NP_569982.1	Gene:	D2hgdh / 31184	FlyBaseID:	FBgn0023507	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001074066.1	Gene:	d2hgdh / 565889	ZFINID:	ZDB-GENE-070112-482	Length:	533	Species:	Danio rerio

Alignment Length:	479	Identity:	235/479 - (49%)
Similarity:	330/479 - (68%)	Gaps:	13/479 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 SGAPIPELTEITDNVQRGNYATLTDKDVAHFEQLL-GKNFVLTEDLEGYNICFLKRIRGNSKLVL 118
            |.|| |.|.          ::.:|.:|::.|..|| |:.....:.|:..|:.:||.::|:|.::|
Zfish    62 SAAP-PRLP----------FSRVTQEDLSFFRALLPGRTITDPDLLKSSNVDWLKTVQGSSDVLL 115

  Fly   119 KPGSTAEVAAILKYCNERRLAVVPQGGNTGLVGGSVPICDEIVLSLARLNKVLSVDEVTGIAVVE 183
            :|.:|..|:.||:|||||.|||.||||||||||||||:.|||:||.:.:|:|.:.|.::||...:
Zfish   116 RPKTTEGVSQILRYCNERNLAVCPQGGNTGLVGGSVPVFDEIILSTSLMNQVFAFDNISGILTCQ 180

  Fly   184 AGCILENFDQRAREVGLTVPLDLGAKASCHIGGNVSTNAGGVRVVRYGNLHGSVLGVEAVLATGQ 248
            |||:|||......|....:|||||||.||||||||||||||:|::|||:|.|:|||:|.|||.|.
Zfish   181 AGCVLENLSHYLEERDFIMPLDLGAKGSCHIGGNVSTNAGGLRLLRYGSLRGTVLGLEVVLADGH 245

  Fly   249 VLDLMSNFKKDNTGYHMKHLFIGSEGTLGVVTKLSMLCPHSSRAVNVAFIGLNSFDDVLKTFVSA 313
            ||:.::..:||||||.:|.|||||||||||:|.:|:|||...:||||||:|.:||..:|:||...
Zfish   246 VLNCLATLRKDNTGYDLKQLFIGSEGTLGVITAVSILCPRKPKAVNVAFLGCSSFQQLLETFQCC 310

  Fly   314 KRNLGEILSSCELIDERALNTALEQFKFLNSPISGFPFYMLIETSGSNGDHDEEKINQFIGDGME 378
            :..||||||:.|.:|...:| .||:...|.:||:..|||::|||:|||..|||||::||:.:.|.
Zfish   311 RGMLGEILSAFEFLDASCMN-LLEKHLKLTNPITECPFYIVIETAGSNATHDEEKLHQFLEEVMT 374

  Fly   379 RGEIQDGTVTGDPGKVQEIWKIREMVPLGLIEKSFCFKYDISLPLRDFYNIVDVMRERCGPLATV 443
            ...:.||||..:..|::.:|.:||.|...|..:.:.:|||||||:...|::|..||...|.:|..
Zfish   375 SSLVTDGTVATEATKIKALWSLRERVTEALTHEGYTYKYDISLPVEKIYDLVQDMRRHLGGMAKN 439

  Fly   444 VCGYGHLGDSNLHLNVSCEEFNGEIYKRVEPFVYEYTSKLKGSISAEHGIGFLKKDYLHYSKDPV 508
            |.||||:||.|||||::....:.::...:||:|||:||:.|||||||||:|..|::|::|||...
Zfish   440 VVGYGHVGDGNLHLNITSPSKDFDLLAAIEPYVYEWTSQWKGSISAEHGLGLKKRNYIYYSKPSE 504

  Fly   509 AIGYMREMKKLLDPNSILNPYKVL 532
            |:..|..:|.:|||..||||||.|
Zfish   505 AVALMGSIKAMLDPKGILNPYKTL 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D2hgdh	NP_569982.1	GlcD	85..532	CDD:223354	227/447 (51%)
		FAD_binding_4	115..252	CDD:279851	82/136 (60%)
		FAD-oxidase_C	291..531	CDD:280983	111/239 (46%)
d2hgdh	NP_001074066.1	GlcD	81..529	CDD:223354	228/449 (51%)
		FAD_binding_4	112..249	CDD:279851	82/136 (60%)
		FAD-oxidase_C	286..526	CDD:280983	110/240 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582429
Domainoid	1	1.000	232	1.000	Domainoid score	I2356
eggNOG	1	0.900	-	-		E1_COG0277
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5534
Inparanoid	1	1.050	473	1.000	Inparanoid score	I1465
OMA	1	1.010	-	-		QHG62883
OrthoDB	1	1.010	-	-		D216115at33208
OrthoFinder	1	1.000	-	-		FOG0003549
OrthoInspector	1	1.000	-	-		oto39513
orthoMCL	1	0.900	-	-		OOG6_100306
Panther	1	1.100	-	-	LDO	PTHR43716
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1958
SonicParanoid	1	1.000	-	-		X2425
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800