Protein Alignment D2hgdh and Ldhd

DIOPT Version :9

• Sequence 1: NP_569982.1
• Gene: D2hgdh / 31184
• FlyBaseID: FBgn0023507
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: XP_036010057.1
• Gene: Ldhd / 52815
• MGIID: 106428
• Length: 583
• Species: Mus musculus
• Alignment Length: 572
• Identity: 140/572 - (24%)
• Similarity: 239/572 - (41%)
• Gaps: 90/572 - (15%)

  Fly    11 RLASAGATTL----MRRPITTTTITTTSRTALAATYP----------AFATTVRTMAGSGAPIPE 61
            |||.:...||    :::......|..:.|.|..|:.|          |.|..:|...      ..
Mouse    52 RLARSAEATLNRLHLKQAPPRAAIGHSERQAGKASSPPSYSPLSCGLAMAMLLRVAT------QR 110

  Fly    62 LTEITDNVQRGNYATLTDKDVAHFEQLLGKNFVLTEDLEGYNICFLKRIRGNSK---------LV 117
            |:.......||:...|:...|...:.::|...|.|...       ::...|:.:         .|
Mouse   111 LSPWRSFCSRGSQGGLSQDFVEALKAVVGSPHVSTASA-------VREQHGHDESMHRCQPPDAV 168

  Fly   118 LKPGSTAEVAAILKYCNERRLAVVPQGGNTGLVGGSVPICDEIVLSLARLNKVLSVDEVTGIAVV 182
            :.|.:..:|:.:...|..:.:.::|.|..||:.||...:...:.::|..::::..::......||
Mouse   169 VWPQNVDQVSRVASLCYNQGVPIIPFGTGTGVEGGVCAVQGGVCINLTHMDQITELNTEDFSVVV 233

  Fly   183 EAGCILENFDQRAREVGLTVPLDLGAKASCHIGGNVSTNAGGVRVVRYGNLHGSVLGVEAVLATG 247
            |.|...:..:...|:.||..|:|.||.||  :.|..:|.|.|...||||.:..:|:.:|.||..|
Mouse   234 EPGVTRKALNTHLRDSGLWFPVDPGADAS--LCGMAATGASGTNAVRYGTMRDNVINLEVVLPDG 296

  Fly   248 QVLDLMS---NFKKDNTGYHMKHLFIGSEGTLGVVTKLSML---CPHSSRAVNVAF----IGLNS 302
            ::|....   :::|...||::..||:|||||||::|..::.   .|.::.|...||    ..::|
Mouse   297 RLLHTAGRGRHYRKSAAGYNLTGLFVGSEGTLGIITSTTLRLHPAPEATVAATCAFPSVQAAVDS 361

  Fly   303 FDDVLKTFVSAKRNLGEILSSCELIDERALNTALEQFKFLNSPISGFPFYMLIETSGSNGDHDEE 367
            ...:|:..|...|        .|.:|: .:..|..:...||.|::...|   :|..||
Mouse   362 TVQILQAAVPVAR--------IEFLDD-VMMDACNRHSKLNCPVAPTLF---LEFHGS------- 407

  Fly   368 KINQFIGDGMERGEIQDGTVTGDPG-----------KVQEIWKIRE---MVPLGLIEKSFCFKYD 418
              .|.:.:.::|.|    .:|.|.|           |..|:|..|.   ...|.|...|..:..|
Mouse   408 --QQTLAEQLQRTE----AITQDNGGSHFSWAKEAEKRNELWAARHNAWYAALALSPGSKAYSTD 466

  Fly   419 ISLPLRDFYNIVDVMRERCGPLATVVCGYGHLGDSNLHLNVSCEEFNGEIYKRVEPFVYEYTSK- 482
            :.:|:.....|:...:|............||:||.|.|..:..:..:.|..:||:.|......:
Mouse   467 VCVPISRLPEILVETKEEIKASKLTGAIVGHVGDGNFHCILLVDPDDAEEQRRVKAFAENLGRRA 531

  Fly   483 --LKGSISAEHGIGFLKKDYLHYSKDPVAIGYMREMKKLLDPNSILNPYKVL 532
              |.|:.:.|||||..|:..|.....||.:..||::|..|||..::||.|||
Mouse   532 LALGGTCTGEHGIGLGKRQLLQEEVGPVGVETMRQLKNTLDPRGLMNPGKVL 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
D2hgdh	NP_569982.1	GlcD	85..532	CDD:223354	120/482 (25%)
		FAD_binding_4	115..252	CDD:279851	38/145 (26%)
		FAD-oxidase_C	291..531	CDD:280983	63/260 (24%)
Ldhd	XP_036010057.1	PLN02805	117..583	CDD:178402	124/499 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1267
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216115at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100306
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.670