DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D2hgdh and Ldhd

DIOPT Version :9

Sequence 1:	NP_569982.1	Gene:	D2hgdh / 31184	FlyBaseID:	FBgn0023507	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001008893.1	Gene:	Ldhd / 307858	RGDID:	1308107	Length:	501	Species:	Rattus norvegicus

Alignment Length:	430	Identity:	113/430 - (26%)
Similarity:	187/430 - (43%)	Gaps:	80/430 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 VLKPGSTAEVAAILKYCNERRLAVVPQGGNTGLVGGSVPICDEIVLSLARLNKVLSVDEVTGIAV 181
            |:.|.:..:|:.:...|..:.:.::|.|..||:.||...:...:.:||..:::::.::......|
  Rat    81 VVWPQNVDQVSRLASLCYNQGVPIIPFGTGTGVEGGVCAVQGGVCISLTHMDQIMELNTEDFSVV 145

  Fly   182 VEAGCILENFDQRAREVGLTVPLDLGAKASCHIGGNVSTNAGGVRVVRYGNLHGSVLGVEAVLAT 246
            ||.|...:..:...|..||..|:|.||.||  :.|..:|.|.|...||||.:..:|:.:|.||..
  Rat   146 VEPGVTRKALNTHLRNSGLWFPVDPGADAS--LCGMAATGASGTNAVRYGTMRDNVINLEVVLPD 208

  Fly   247 GQVLDLMS---NFKKDNTGYHMKHLFIGSEGTLGVVTKLSML---CPHSSRAVNVAF----IGLN 301
            |::|....   :::|...||::..||:|||||||::|..::.   .|.::.|...||    ..::
  Rat   209 GRLLHTAGRGRHYRKSAAGYNLTGLFVGSEGTLGIITSATLRLHPAPEATVAATCAFPSVQAAVD 273

  Fly   302 SFDDVLKTFVSAKRNLGEILSSCELIDERALNTALEQFKFLNSPISGFPFYMLIETSGSNGDHDE 366
            |...:|:..|...|        .|.:|| .:..|..:...||.|::...|   :|..||
  Rat   274 STVQILQAAVPVAR--------IEFLDE-VMMDACNRHSKLNCPVAPTLF---LEFHGS------ 320

  Fly   367 EKINQFIGDGMERGEIQDGTVTGDPG-----------KVQEIWKIREMVPLGLIEKSFCFKYDIS 420
               .|.:.:.::|.|    .:|.|.|           |..|:|..|...            :..:
  Rat   321 ---QQALAEQLQRTE----AITQDNGGSHFSWAKEAEKRNELWAARHNA------------WYAA 366

  Fly   421 LPLRDFYNIVDVMRERCGPLATVVCGYGHLGDSNLHLNVSCEEFNGEIYKRVEPFVYEYTSK--- 482
            |.||              |...:|   ||:||.|.|..:.....:.|..:||:.|......:
  Rat   367 LALR--------------PGRVIV---GHVGDGNFHCILLVNPDDVEEQRRVKAFAENLGRRALA 414

  Fly   483 LKGSISAEHGIGFLKKDYLHYSKDPVAIGYMREMKKLLDP 522
            |.|:.:.|||||..|:..|.....||.:..||::|..|||
  Rat   415 LHGTCTGEHGIGLGKRQLLQEEVGPVGVETMRQLKDTLDP 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D2hgdh	NP_569982.1	GlcD	85..532	CDD:223354	113/430 (26%)
		FAD_binding_4	115..252	CDD:279851	39/134 (29%)
		FAD-oxidase_C	291..531	CDD:280983	60/250 (24%)
Ldhd	NP_001008893.1	GlcD	46..454	CDD:223354	111/428 (26%)
		FAD_binding_4	78..214	CDD:279851	39/134 (29%)
		FAD-oxidase_C	255..455	CDD:280983	61/254 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216115at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100306
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.720