Protein Alignment D2hgdh and Ldhd

DIOPT Version :10

• Sequence 1: NP_569982.1
• Gene: D2hgdh / 31184
• FlyBaseID: FBgn0023507
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: NP_001386059.1
• Gene: Ldhd / 307858
• RGDID: 1308107
• Length: 482
• Species: Rattus norvegicus
• Alignment Length: 500
• Identity: 130/500 - (26%)
• Similarity: 221/500 - (44%)
• Gaps: 74/500 - (14%)

  Fly    71 RGNYATLTDKDVAHFEQLLGKNFVLTEDLEGYNICFLKRIRGNSK---------LVLKPGSTAEV 126
            ||:...|:...|...:.::|...|.|...       :::..|:.:         .|:.|.:..:|
  Rat    19 RGSQGGLSQDFVEALKAVVGSPHVSTASA-------VRQHHGHDESMHRCRPPDAVVWPQNVDQV 76

  Fly   127 AAILKYCNERRLAVVPQGGNTGLVGGSVPICDEIVLSLARLNKVLSVDEVTGIAVVEAGCILENF 191
            :.:...|..:.:.::|.|..||:.||...:...:.:||..:::::.::......|||.|...:..
  Rat    77 SRLASLCYNQGVPIIPFGTGTGVEGGVCAVQGGVCISLTHMDQIMELNTEDFSVVVEPGVTRKAL 141

  Fly   192 DQRAREVGLTVPLDLGAKASCHIGGNVSTNAGGVRVVRYGNLHGSVLGVEAVLATGQVLDLMS-- 254
            :...|..||..|:|.||.||  :.|..:|.|.|...||||.:..:|:.:|.||..|::|....
  Rat   142 NTHLRNSGLWFPVDPGADAS--LCGMAATGASGTNAVRYGTMRDNVINLEVVLPDGRLLHTAGRG 204

  Fly   255 -NFKKDNTGYHMKHLFIGSEGTLGVVTKLSML---CPHSSRAVNVAF----IGLNSFDDVLKTFV 311
             :::|...||::..||:|||||||::|..::.   .|.::.|...||    ..::|...:|:..|
  Rat   205 RHYRKSAAGYNLTGLFVGSEGTLGIITSATLRLHPAPEATVAATCAFPSVQAAVDSTVQILQAAV 269

  Fly   312 SAKRNLGEILSSCELIDERALNTALEQFKFLNSPISGFPFYMLIETSGSNGDHDEEKINQFIGDG 376
            ...|        .|.:|| .:..|..:...||.|::...|   :|..||         .|.:.:.
  Rat   270 PVAR--------IEFLDE-VMMDACNRHSKLNCPVAPTLF---LEFHGS---------QQALAEQ 313

  Fly   377 MERGEIQDGTVTGDPG-----------KVQEIWKIRE---MVPLGLIEKSFCFKYDISLPLRDFY 427
            ::|.|    .:|.|.|           |..|:|..|.   ...|.|...|..:..|:.:|:....
  Rat   314 LQRTE----AITQDNGGSHFSWAKEAEKRNELWAARHNAWYAALALRPGSKAYSTDVCVPISRLP 374

  Fly   428 NIVDVMRE--RCGPLATVVCGYGHLGDSNLHLNVSCEEFNGEIYKRVEPFVYEYTSK---LKGSI 487
            .|:...:|  :...|..|:  .||:||.|.|..:.....:.|..:||:.|......:   |.|:.
  Rat   375 EILVETKEELKASKLTGVI--VGHVGDGNFHCILLVNPDDVEEQRRVKAFAENLGRRALALHGTC 437

  Fly   488 SAEHGIGFLKKDYLHYSKDPVAIGYMREMKKLLDPNSILNPYKVL 532
            :.|||||..|:..|.....||.:..||::|..|||..::||.|||
  Rat   438 TGEHGIGLGKRQLLQEEVGPVGVETMRQLKDTLDPRGLMNPGKVL 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
D2hgdh	NP_569982.1	GlcD	77..533	CDD:440046	127/493 (26%)
Ldhd	NP_001386059.1	GlcD	25..482	CDD:440046	126/492 (26%)