DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D2hgdh and D2hgdh

DIOPT Version :9

Sequence 1:	NP_569982.1	Gene:	D2hgdh / 31184	FlyBaseID:	FBgn0023507	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	XP_006245582.1	Gene:	D2hgdh / 301624	RGDID:	1307976	Length:	553	Species:	Rattus norvegicus

Alignment Length:	479	Identity:	235/479 - (49%)
Similarity:	337/479 - (70%)	Gaps:	2/479 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 SGAPIPELTEITDNVQRGNYATLTDKDVAHFEQLL-GKNFVLTEDLEGYNICFLKRIRGNSKLVL 118
            ||:|...||.....|||..::|::::|:|.||.:: |:.....|.|:..|:.:|:.:||.||::|
  Rat    72 SGSPEVMLTPERYPVQRLPFSTVSEEDLAAFECIIPGRVITDPEQLQTCNVDWLRTVRGCSKVLL 136

  Fly   119 KPGSTAEVAAILKYCNERRLAVVPQGGNTGLVGGSVPICDEIVLSLARLNKVLSVDEVTGIAVVE 183
            :|.::.||:.||::|.:|.|||.|||||||:||||||:.||::||.|.:|:|:|..:|:||.|.:
  Rat   137 RPQTSEEVSQILRHCYKRNLAVNPQGGNTGMVGGSVPVFDEVILSTALMNQVISFHDVSGILVCQ 201

  Fly   184 AGCILENFDQRAREVGLTVPLDLGAKASCHIGGNVSTNAGGVRVVRYGNLHGSVLGVEAVLATGQ 248
            |||:||...:..:|....:|||||||.||||||||:|||||:|.:|||:|.|:|||:|.|||.|.
  Rat   202 AGCVLEELSRYVQERDFIMPLDLGAKGSCHIGGNVATNAGGLRFLRYGSLRGTVLGLEVVLADGT 266

  Fly   249 VLDLMSNFKKDNTGYHMKHLFIGSEGTLGVVTKLSMLCPHSSRAVNVAFIGLNSFDDVLKTFVSA 313
            :|:.:::.:||||||.:|.:||||||||||:|.:|::||...:||||||:|...|.:||:||.:.
  Rat   267 ILNCLTSLRKDNTGYDLKQMFIGSEGTLGVITAVSIVCPPRPKAVNVAFLGCPGFTEVLQTFRTC 331

  Fly   314 KRNLGEILSSCELIDERALNTALEQFKFLNSPISGFPFYMLIETSGSNGDHDEEKINQFIGDGME 378
            |..||||||:.|.:|...:. .:.|...|.:|:...|||:|:|||||:..||.||:...:...:.
  Rat   332 KGQLGEILSAFEFMDAECMQ-LVGQHLHLTNPVQESPFYVLVETSGSSAGHDAEKLTNVLEQVLN 395

  Fly   379 RGEIQDGTVTGDPGKVQEIWKIREMVPLGLIEKSFCFKYDISLPLRDFYNIVDVMRERCGPLATV 443
            .|.:.|||:..|..|||.:|.:||.:...|....:.||||:|||:...|::|..:|.|.||.|..
  Rat   396 SGLVIDGTMATDQRKVQMLWALRERITEALSRDGYVFKYDLSLPVERLYDLVIDLRTRLGPRAKH 460

  Fly   444 VCGYGHLGDSNLHLNVSCEEFNGEIYKRVEPFVYEYTSKLKGSISAEHGIGFLKKDYLHYSKDPV 508
            |.|||||||.||||||:.|.|:.|:...:||:||.:|::.:||:|||||:||.||:.|.|||.||
  Rat   461 VVGYGHLGDGNLHLNVTAEAFSQELLGALEPYVYAWTAEQRGSVSAEHGLGFKKKNVLGYSKPPV 525

  Fly   509 AIGYMREMKKLLDPNSILNPYKVL 532
            |:..|:::|.:|||..||||||.|
  Rat   526 AVKLMQQLKAMLDPKGILNPYKTL 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D2hgdh	NP_569982.1	GlcD	85..532	CDD:223354	223/447 (50%)
		FAD_binding_4	115..252	CDD:279851	78/136 (57%)
		FAD-oxidase_C	291..531	CDD:280983	113/239 (47%)
D2hgdh	XP_006245582.1	GlcD	108..550	CDD:223354	221/442 (50%)
		FAD_binding_4	133..270	CDD:279851	77/136 (57%)
		FAD-oxidase_C	307..547	CDD:280983	112/239 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342415
Domainoid	1	1.000	231	1.000	Domainoid score	I2356
eggNOG	1	0.900	-	-		E1_COG0277
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5534
Inparanoid	1	1.050	473	1.000	Inparanoid score	I1449
OMA	1	1.010	-	-		QHG62883
OrthoDB	1	1.010	-	-		D216115at33208
OrthoFinder	1	1.000	-	-		FOG0003549
OrthoInspector	1	1.000	-	-		oto97519
orthoMCL	1	0.900	-	-		OOG6_100306
Panther	1	1.100	-	-	LDO	PTHR43716
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2425
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770