Protein Alignment D2hgdh and LDHD

DIOPT Version :9

• Sequence 1: NP_569982.1
• Gene: D2hgdh / 31184
• FlyBaseID: FBgn0023507
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: XP_024305942.1
• Gene: LDHD / 197257
• HGNCID: 19708
• Length: 567
• Species: Homo sapiens
• Alignment Length: 500
• Identity: 121/500 - (24%)
• Similarity: 194/500 - (38%)
• Gaps: 136/500 - (27%)

  Fly   122 STAEVAAILKYCNERRLAVVPQGGNTGLVGGSVPICDEIVLSLARLNKVLSVDEVTGIAVVEAGC 186
            |..:|.:.|..|..       |||          :|    ::|..::::|.:::.....|||.|.
Human   115 SETQVCSGLSTCPN-------QGG----------VC----VNLTHMDRILELNQEDFSVVVEPGV 158

  Fly   187 ILENFDQRAREVGLTVPLDLGAKASCHIGGNVSTNAGGVRVVRYGNLHGSVLGVEAVLATGQVLD 251
            ..:..:...|:.||..|:|.||.||  :.|..:|.|.|...||||.:..:||.:|.||..|::|.
Human   159 TRKALNAHLRDSGLWFPVDPGADAS--LCGMAATGASGTNAVRYGTMRDNVLNLEVVLPDGRLLH 221

  Fly   252 LMS---NF-----------------------KKDNTGYHMKHLFIGSEGTLGVVTKLSML---CP 287
            ...   :|                       :|...||::..||:|||||||::|..::.   .|
Human   222 TAGRGRHFRFGFWPEIPHHTAWYSPCVSLGRRKSAAGYNLTGLFVGSEGTLGLITATTLRLHPAP 286

  Fly   288 HSSRAVNVAFIGLNSFDD----VLKTFVSAKRNLGEILSSCELIDERALNTALEQFKFLNSPISG 348
            .::.|...||..:.:..|    :|:..|...|        .|.:|| .:..|..::..||..::.
Human   287 EATVAATCAFPSVQAAVDSTVHILQAAVPVAR--------IEFLDE-VMMDACNRYSKLNCLVAP 342

  Fly   349 FPFYMLIETSGSNGDHDEEKINQFIGDGMERGE---IQDGTVTGDPGKVQE----IWKIREMV-P 405
            ..|   :|..||         .|.:.:.::|.|   .|:|.......|..|    :|..|... .
Human   343 TLF---LEFHGS---------QQALEEQLQRTEEIVQQNGASDFSWAKEAEERSRLWTARHNAWY 395

  Fly   406 LGLIEKSFCFKY--DISLPLRDFYNIVDVMRE--------------------------------- 435
            ..|..:..|..|  |:.:|:.....||...:|
Human   396 AALATRPGCKGYSTDVCVPISRLPEIVVQTKEDLNASGLTGSAHPAAGERWGGVRADQSLGQQEA 460

  Fly   436 ----------RCGPLATVVCGYGHLGDSNLHLNVSCEEFNGEIYKRVEPFVYEYTSK---LKGSI 487
                      ..||..::|   ||:||.|.|..:.....:.|...||:.|..:...:   |.|:.
Human   461 RGGLGWRIVLSSGPPGSIV---GHVGDGNFHCILLVNPDDAEELGRVKAFAEQLGRRALALHGTC 522

  Fly   488 SAEHGIGFLKKDYLHYSKDPVAIGYMREMKKLLDPNSILNPYKVL 532
            :.|||||..|:..|......|.:..||::|.:|||..::||.|||
Human   523 TGEHGIGMGKRQLLQEEVGAVGVETMRQLKAVLDPQGLMNPGKVL 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
D2hgdh	NP_569982.1	GlcD	85..532	CDD:223354	119/498 (24%)
		FAD_binding_4	115..252	CDD:279851	38/129 (29%)
		FAD-oxidase_C	291..531	CDD:280983	65/299 (22%)
LDHD	XP_024305942.1	FAD-oxidase_C	<125..567	CDD:332893	116/488 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1267
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216115at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100306
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.670