Protein Alignment D2hgdh and F54D5.12

DIOPT Version :9

• Sequence 1: NP_569982.1
• Gene: D2hgdh / 31184
• FlyBaseID: FBgn0023507
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: NP_496465.1
• Gene: F54D5.12 / 174764
• WormBaseID: WBGene00010055
• Length: 487
• Species: Caenorhabditis elegans
• Alignment Length: 517
• Identity: 215/517 - (41%)
• Similarity: 311/517 - (60%)
• Gaps: 43/517 - (8%)

  Fly    21 MRRPITTTTITTTSRTALAATYPAFATTVRTMAGSGAPIPELTEITDNVQRGNYATLTDKDVAHF 85
            :|||      |.:....|||.:..||..:::                             |:..|
 Worm     9 IRRP------TRSYAAVLAARHEGFAKVMQS-----------------------------DLMAF 38

  Fly    86 EQLLGKNFVLTEDLEGYNICFLKRIRGNSKLVLKPGSTAEVAAILKYCNERRLAVVPQGGNTGLV 150
            |..||::.|..:|:..:...:..:.:|...:||.|.||.||:|||.||::.:|||||||||||||
 Worm    39 ENFLGQDAVKKDDITNHTTDWTGQFKGPGSVVLYPKSTEEVSAILAYCSKNKLAVVPQGGNTGLV 103

  Fly   151 GGSVPICDEIVLSLARLNKVLSVDEVTGIAVVEAGCILENFDQRAREVGLTVPLDLGAKASCHIG 215
            |||:|:.||:|:|:.::||..|.|:..||...::|.|||:.|.:..::|..:|.|||||.||.||
 Worm   104 GGSIPVHDEVVISMNKINKQFSFDDTMGILKCDSGFILEDLDNKLAKLGYMMPFDLGAKGSCQIG 168

  Fly   216 GNVSTNAGGVRVVRYGNLHGSVLGVEAVLAT--GQVLDLMSNFKKDNTGYHMKHLFIGSEGTLGV 278
            ||::|.|||:|::|||:||..:||:..||..  |.||.|.|:.:||||..|..|||:||||.|||
 Worm   169 GNIATCAGGIRLIRYGSLHAHLLGLTVVLPDEHGTVLHLGSSIRKDNTTLHTPHLFLGSEGQLGV 233

  Fly   279 VTKLSMLCPHSSRAVNVAFIGLNSFDDVLKTFVSAKRNLGEILSSCELIDE---RALNTALEQFK 340
            :|.::|......::|..|.:|:.||....:....||.:|.|||||.||:|:   ..|.|.|....
 Worm   234 ITSVTMTAVPKPKSVQSAMLGIESFKKCCEVLKLAKSSLTEILSSFELLDDATMECLKTNLGLHP 298

  Fly   341 FLNSPISGFPFYMLIETSGSNGDHDEEKINQFIGDGMERGEIQDGTVTGDPGKVQEIWKIREMVP 405
            .||:|.   ||.:|:||||||.|||.||::.|:.:.:.:..|.||.:.|...:..::|::||..|
 Worm   299 VLNAPT---PFSILVETSGSNEDHDMEKMSAFLDECLSKNLIIDGVLAGSSAEATKMWQLRESAP 360

  Fly   406 LGLIEKSFCFKYDISLPLRDFYNIVDVMRERCGPLATVVCGYGHLGDSNLHLNVSCEEFNGEIYK 470
            |.:....:.:|:|:||||.::|.:.:||:||||.||..:..||||||.|.|||::.|:.|.|:.|
 Worm   361 LAVTRDGYVYKHDVSLPLENYYELTNVMKERCGSLAKRIVTYGHLGDGNTHLNITSEKHNEELEK 425

  Fly   471 RVEPFVYEYTSKLKGSISAEHGIGFLKKDYLHYSKDPVAIGYMREMKKLLDPNSILNPYKVL 532
            .:.||:||:.....||||||||||.||..|..:.|||......:::|.:.|||.||||||.:
 Worm   426 LLYPFLYEWVVDHGGSISAEHGIGQLKLPYSTFGKDPEERLLTKKLKNIFDPNGILNPYKTI 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
D2hgdh	NP_569982.1	GlcD	85..532	CDD:223354	205/451 (45%)
		FAD_binding_4	115..252	CDD:279851	74/138 (54%)
		FAD-oxidase_C	291..531	CDD:280983	104/242 (43%)
F54D5.12	NP_496465.1	GlcD	37..485	CDD:223354	203/450 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160183
Domainoid	1	1.000	206	1.000	Domainoid score	I1703
eggNOG	1	0.900	-	-		E1_COG0277
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5534
Inparanoid	1	1.050	410	1.000	Inparanoid score	I1052
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62883
OrthoDB	1	1.010	-	-		D216115at33208
OrthoFinder	1	1.000	-	-		FOG0003549
OrthoInspector	1	1.000	-	-		oto19864
orthoMCL	1	0.900	-	-		OOG6_100306
Panther	1	1.100	-	-	LDO	PTHR43716
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1958
SonicParanoid	1	1.000	-	-		X2425
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.840