Protein Alignment D2hgdh and DHCR24

DIOPT Version :9

• Sequence 1: NP_569982.1
• Gene: D2hgdh / 31184
• FlyBaseID: FBgn0023507
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: NP_055577.1
• Gene: DHCR24 / 1718
• HGNCID: 2859
• Length: 516
• Species: Homo sapiens
• Alignment Length: 410
• Identity: 79/410 - (19%)
• Similarity: 137/410 - (33%)
• Gaps: 125/410 - (30%)

  Fly   164 LARLNKVLSVDEVTGIAVVEAGCILENFDQRAREVGLTVPL-----DL---------GAKASCHI 214
            :..|..:|.||....|..||....:.........:|.|:|:     ||         |.::|.|
Human   115 MINLMDILEVDTKKQIVRVEPLVTMGQVTALLTSIGWTLPVLPELDDLTVGGLIMGTGIESSSH- 178

  Fly   215 GGNVSTNAGGVRVVRYGNLHGSVLGVEAVLATGQVLDLMSNFKKDNTGYHMKHLFIG---SEGTL 276
                          :||.........|.|||.|..:....:...|        ||..   |.|||
Human   179 --------------KYGLFQHICTAYELVLADGSFVRCTPSENSD--------LFYAVPWSCGTL 221

  Fly   277 GVVTKLSMLCPHSSRAVNVAFIGLNSFDDVLKTFVSAKRN-----LGEILSSCELIDERALNTAL 336
            |.:....:....:.:.|.:.|..:...:.:...|....:.     :..:|.|   :||..:.|.:
Human   222 GFLVAAEIRIIPAKKYVKLRFEPVRGLEAICAKFTHESQRQENHFVEGLLYS---LDEAVIMTGV 283

  Fly   337 -----EQFKFLNSPISGF--PFYMLIETSGSNGDHDEE--KINQFIGDGME----RGEIQDGTVT 388
                 |..| ||| |..:  |::.         .|.|.  |.|:   :|:|    |......|.:
Human   284 MTDEAEPSK-LNS-IGNYYKPWFF---------KHVENYLKTNR---EGLEYIPLRHYYHRHTRS 334

  Fly   389 GDPGKVQEIWKIREMVPLGLIEKSFCFKY--------DISL-------PLRDFYNIVDVMRERCG 438
                   ..|::::::|.|   .:..|:|        .|||       .||..|....|:::...
Human   335 -------IFWELQDIIPFG---NNPIFRYLFGWMVPPKISLLKLTQGETLRKLYEQHHVVQDMLV 389

  Fly   439 PLATVVCGYGHLGDSNLHLN---------------VSCEEFNGEIYKRV----EPFVYEYTSK-- 482
            |:..:.... |...:::|:.               |..:....|:|..:    ||.|..:.::
Human   390 PMKCLQQAL-HTFQNDIHVYPIWLCPFILPSQPGLVHPKGNEAELYIDIGAYGEPRVKHFEARSC 453

  Fly   483 ---LKGSISAEHGIGFLKKD 499
               |:..:.:.||...|..|
Human   454 MRQLEKFVRSVHGFQMLYAD 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
D2hgdh	NP_569982.1	GlcD	85..532	CDD:223354	79/410 (19%)
		FAD_binding_4	115..252	CDD:279851	22/101 (22%)
		FAD-oxidase_C	291..531	CDD:280983	49/266 (18%)
DHCR24	NP_055577.1	GlcD	114..>263	CDD:223354	33/170 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900