DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ph-p and SAMD1

DIOPT Version :9

Sequence 1:	NP_476871.2	Gene:	ph-p / 31181	FlyBaseID:	FBgn0004861	Length:	1589	Species:	Drosophila melanogaster
Sequence 2:	NP_612361.1	Gene:	SAMD1 / 90378	HGNCID:	17958	Length:	538	Species:	Homo sapiens

Alignment Length:	494	Identity:	102/494 - (20%)
Similarity:	158/494 - (31%)	Gaps:	129/494 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1120 GGSIPATPTKETPSKGPTATLVPIGSPKTPVSGKDTCTTPKSSTPATVSASVEASSSTGEALSNG 1184
            |.:.||.|.....:....|...|..:|..|...........:..|...:|:..|..|.|.|
Human   105 GATPPAPPRAPRGAPAAAAAAAPPPTPAPPPPPAPVAAAAPARAPRAAAAAATAPPSPGPA---- 165

  Fly  1185 DASDRSSTPSKGATTPTSKQSNAAVQPPSS---TTPNSVSGKEEP-------------------- 1226
            ....|:...:..|..|.:..:..||.||:.   ..|.:|:.:|.|
Human   166 QPGPRAQRAAPLAAPPPAPAAPPAVAPPAGPRRAPPPAVAAREPPLPPPPQPPAPPQQQQPPPPQ 230

  Fly  1227 -------KLATCGSLTSATSTSTTTTITNGIGVA--RTTASTAVSTASTTTTSSGTFITSCTSTT 1282
                   .....|......|.........|.|.|  |.|.............:.|..     ..|
Human   231 PQPPPEGGAVRAGGAARPVSLREVVRYLGGSGGAGGRLTRGRVQGLLEEEAAARGRL-----ERT 290

  Fly  1283 TTTTSSISNGSKD---LPKAMIKPNVLTHVIDGFIIQEANEPFPVTRQRYADKDVSDEPPKKKAT 1344
            .....::..|.:.   .|.|..:|:......:..::::..|          :.|..||
Human   291 RLGALALPRGDRPGRAPPAASARPSRSKRGGEERVLEKEEE----------EDDDEDE------- 338

  Fly  1345 MQEDIKLSGIASAPGSDMVACEQ-------CGKMEHKAKLKRKRYCSPGCSRQAKNGIGGVGSGE 1402
             .|:..:|..:..|.||..|..|       .|....|.::|....|.|   .|.::    .|.|.
Human   339 -DEEDDVSEGSEVPESDRPAGAQHHQLNGERGPQSAKERVKEWTPCGP---HQGQD----EGRGP 395

  Fly  1403 TNGLGTGGIVGVDAMALVDRLDEAMAEEKMQTEATPKLSESFPILGASTEVPPMSLPVQAAISAP 1467
            ..|.||..:..:.||           .::..|              ||....|         .:|
Human   396 APGSGTRQVFSMAAM-----------NKEGGT--------------ASVATGP---------DSP 426

  Fly  1468 SPLAMPLGSPLSVALPTLAPLSVVTSGA--APKSSEVNGTDRP--PISSWSVDDVSNFIRELPGC 1528
            ||:.:|.|.|   |||          ||  .|........::|  |: .|:|.||..:..| .|.
Human   427 SPVPLPPGKP---ALP----------GADGTPFGCPPGRKEKPSDPV-EWTVMDVVEYFTE-AGF 476

  Fly  1529 QDYVDDFIQQEIDGQALLLLKEKHLVNAMGMKLGPALKI 1567
            .:....|.:|||||::|||::...::..:.::|||||||
Human   477 PEQATAFQEQEIDGKSLLLMQRTDVLTGLSIRLGPALKI 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ph-p	NP_476871.2	SAM_Ph1,2,3	1508..1576	CDD:188976	24/62 (39%)
ph-p	NP_476871.2	SAM	1511..1576	CDD:197735	22/57 (39%)
SAMD1	NP_612361.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	92..247		26/145 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..458		47/252 (19%)
		SAM_Atherin-like	459..527	CDD:188982	23/59 (39%)
		SAM	459..525	CDD:197735	23/59 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910