DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ph-p and l(3)mbt

DIOPT Version :9

Sequence 1:	NP_476871.2	Gene:	ph-p / 31181	FlyBaseID:	FBgn0004861	Length:	1589	Species:	Drosophila melanogaster
Sequence 2:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster

Alignment Length:	1595	Identity:	267/1595 - (16%)
Similarity:	492/1595 - (30%)	Gaps:	509/1595 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 QQQLQLQQQLSEANGG----------GAASAGAGGAASPANSQQSQQQQHSTAISTMSPMQLAAA 301
            |.|..:...:|.||||          |.||| :||..:|.:......::.......::||
  Fly    13 QLQRNISLSMSPANGGVISPSTANCNGVASA-SGGNPNPNSLLTLAPRKEELRFLPLAPM----- 71

  Fly   302 TGGVGGDWTQGRTVQLMQPSTSFLYPQMIVSGNLLHPGGLGQQPIQVITAGKPFQGNGPQMLTTT 366
                ||:.|...|:..:||..|.|....||             |..:.:||
  Fly    72 ----GGNKTCNITISNVQPMKSKLKSVNIV-------------PNSIKSAG-------------- 105

  Fly   367 TQNAKQMIGGQAGFAGGNYATCIPTNHNQSPQTVLFSPMNVISPQQQQNLLQSMAAAAQQQQLTQ 431
                   .|...|.|.......:|:..|.|...|.     :::|.::..||...|:..|...:
  Fly   106 -------AGATVGSADAPLFQLVPSPSNPSQPLVA-----ILAPNRKTTLLGGGASNGQPVVI-- 156

  Fly   432 QQQQFNQQQQQQLTQQQQQLTAALAKVGVDAQGKLAQKVVQKVTTTSSAVQAATGPGSTGSTQTQ 496
                     :......:..||...:...:...|              ||..||.|.|:.|:..|
  Fly   157 ---------RSGTPLHKNSLTVETSNKPIQPGG--------------SAAAAAVGGGTGGAPLT- 197

  Fly   497 QVQQVQQQQQQTTQTTQQCVQVSQSTLPVGVGGQSVQTAQLLNAGQAQQMQIPWFLQNAAGLQPF 561
                                .|.::.:|..:  |:....|:.:.|...|:.:   |.|.  |:|.
  Fly   198 --------------------LVGKTVVPPKI--QAATPVQIPSTGPGAQVSL---LANP--LKPR 235

  Fly   562 GPNQIILRNQPDGTQGMFIQQQPATQTLQTQQNQIIQCNVTQTPTKARTQLDALA-PKQQQQQQQ 625
            .|               .|..:.|...|:.:.:|:            ::..:||. .|....::.
  Fly   236 AP---------------LILSKVAVDKLRLKFSQV------------KSNPNALVLGKANHVKKL 273

  Fly   626 VGTTNQTQQQQLAVATAQLQQQQQQLTAAALQRPGAPVMPHNGTQVRPASSVSTQTAQNQSLLKA 690
            :.:.|.:.:.:    |...|:..:|.|:|:..:|  .|.|.....:  |:.|.|......||:|:
  Fly   274 LTSPNPSGEDK----TRSTQKNNKQNTSASQLKP--VVAPKTAMPI--ATEVPTADNNKMSLIKS 330

  Fly   691 K--------MRNKQQPVRPALATLKTEIGQVAGQNKVVGHLTTVQQQQQATNLQQVVNAAGNKMV 747
            |        :.:::.|:.||:|.:.|...:|.                        |.......:
  Fly   331 KPVAIKAVPLPSQEAPIVPAVAPVVTSPEKVD------------------------VKPTAKPSI 371

  Fly   748 VMSTTGTPITLQ---NGQTLHAATAAGVDKQQQQLQLFQKQQILQQQQMLQQQIAAIQ-----MQ 804
            ..:...||..|:   ||........|...||:...:....::|.|......:::..::     :.
  Fly   372 KTAPKPTPKPLEMSVNGPAKEKKAPAKEQKQKTMDKPPVVKEIAQHTPCGPKELPKLKRSKSFVS 436

  Fly   805 QQQAAVQAQQQQQQQVS-QQQQVNAQQQQAVAQQQQAVAQAQQQQREQQQ-QVAQAQAQHQ---- 863
            ...|:..|..:::..|: ..::|:..:|.:.|.:...:....:.:.|||: ::.:...|:|
  Fly   437 NHPASPVANNERRHSVAIMAKEVDVIEQPSAAIETITIEDDDESEEEQQKPEIKKTPKQNQKPEK 501

  Fly   864 QALANATQQILQVAPN--QFITSHQQQQQQQLHNQLIQQQLQQQAQAQVQAQVQAQAQQQQQQRE 926
            |......|..:.:.|.  ...|:...:::....|..:.......:.:...:.|:.   ...::.|
  Fly   502 QEAPKKKQIPMPILPAGITISTTSTAKKKAVRKNSSVTTISSSSSDSSSYSDVEV---VPTKKTE 563

  Fly   927 QQQNIIQ--QIVVQQSGATSQQTSQQQQHHQSGQLQLSSVPFSVSSSTTPAGIATSSALQAALSA 989
            ::.:::.  .|:..:|...|::..::......   |:...|...|||::....|:..:....|:
  Fly   564 KELSMLPGISIIKAESLPLSREDFERSLRCDE---QVPQTPPKSSSSSSSGSHASEMSPPPKLA- 624

  Fly   990 SGAIFQTAKPGTCSSSSPTSSVVTITNQSSTPLVTSSTVASIQQAQTQSAQV-----HQHQQLIS 1049
                  ..||    ||.|..:.....:..:.|..:|.| ...:::..|:..:     .|...|.:
  Fly   625 ------DPKP----SSPPAKNAKKANDHDANPSPSSKT-NDFKKSMMQNLNMLKWRGQQPANLQN 678

  Fly  1050 ATIAGGTQQ----------QP-QGP-----------PSLTPT--TNPILAMTSMMNATVGHLSTA 1090
            :|:.....:          || |||           |...|:  .:|:|.:....|.........
  Fly   679 STVRFELNEFNFLQINERCQPRQGPAAYFERPLYDRPGRRPSACVHPLLYLCQRCNFHGPAADFL 743

  Fly  1091 PPVTVSV------------TSTAVTSSPGQLVLLSTASSGGGGSIPATPTKETPSKGPTATLVPI 1143
            .|...||            .||...|...:..|..||     |:.|..|.|...:..|..:|..|
  Fly   744 APHFCSVGCVRRSQKRRLPQSTQKESKISRTQLEQTA-----GTAPDLPQKRQTNYKPHKSLSAI 803

  Fly  1144 ---------GSPKTPV--------SGKDTCT-------------------------TPKSSTPAT 1166
                     ..|:.|.        .|||...                         .|::.:...
  Fly   804 QEQLQQRQKDKPRKPFRWSEYLKSKGKDVAAPIHLFLNPFPISPNCFEIGMKLEAIDPENCSLFC 868

  Fly  1167 VSASVEAS-----------SSTGEALSNGDASDRSSTPSKGATTPTSKQSNAAVQPPSSTTPNSV 1220
            |.:.||..           ||..:...|.|:.|   ....|....|::    .:|.|........
  Fly   869 VCSIVEVRGYRLKLSFDGYSSMYDFWVNADSQD---IFPPGWCDETAR----VLQAPKDYNSERF 926

  Fly  1221 S---------GKEEPKLATCGSLTSATSTSTTTTITNGIGVA--------RTTASTAVSTASTTT 1268
            |         ||..|: |..|.|    :......:.||..|.        ..|....|:|.:...
  Fly   927 SWSRYLVKTGGKAAPR-ALFGHL----NMQQQMDVRNGFAVGMHLEAEDLNDTGKICVATVTDIL 986

  Fly  1269 TS-------------------SGTFITSC---------------TSTTTTTTSSISN-----GSK 1294
            ..                   :..:|..|               ..:.......||.     .||
  Fly   987 DERIRVHFDGWDDCYDLWVHITSPYIHPCGWHEGRQQLIVPPDYQKSAFIWDDYISEVGGMAASK 1051

  Fly  1295 DL--PK-------------------AMIKP-NVLTHVIDGFIIQEANEPFPVTRQRYADKDVSDE 1337
            :|  |:                   .:|:| .|:|.  .|:.:|...:.:|.....:.:.|..|.
  Fly  1052 ELFTPRQPMEYQERMKLEVVDQRNPCLIRPATVVTR--KGYRVQLHLDCWPTEYYFWLEDDSPDL 1114

  Fly  1338 PPKK--KATMQEDIKLSGIASAPG---------SDMVACEQCGKMEH-KAKLKRKRYCSP----- 1385
            .|..  :||..|      :.:.||         .|:..|...|..:. ...:...|.|.|
  Fly  1115 HPIGWCEATSHE------LETPPGYLQPKSVMPCDVEGCRGFGNAKRFNLNVHALRECCPYAPEN 1173

  Fly  1386 ---------------------GCSRQAKNGIGGVGSGETNGLGTGGIVGVDAMALVDRLDEAMAE 1429
                                 |.:::.|..                         .....:|:.|
  Fly  1174 WRQWRSKTVKPPRVAPENIRRGWAKKTKRA-------------------------CSEAKQAIKE 1213

  Fly  1430 EKMQTEATPKLSESFPILGASTEVPPM------------------SLPVQAAISAPSPLAMPLGS 1476
            :..|....||::|   ::.|..:..|.                  .:|.:.:::.........|
  Fly  1214 DSQQEIVYPKVAE---VVQAKRKTSPCEEKVVKKQKQMQKEEDAEQVPDERSLAIARSFVKDYG- 1274

  Fly  1477 PLSVALPTLAP-LSVVTSGAAPKSSEVNGTDRPPISSWSVDDVSNFIRELPGCQDYVDDFIQQEI 1540
                  |...| ..:....:|.|..:|...   |: .|:..||..:|.......|......:|:|
  Fly  1275 ------PQFLPNYRLWQLNSAFKLDDVRTN---PL-HWTSWDVCEYIERALDSTDIAKVIFEQDI 1329

  Fly  1541 DGQALLLLKEKHLVNAMGMKLGPALKIVAKVESIK 1575
            ||:|||:|..|.|...:.:|:|||:|:.:.:.:::
  Fly  1330 DGRALLMLGRKELDTYLKLKVGPAVKLYSLILNLR 1364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ph-p	NP_476871.2	SAM_Ph1,2,3	1508..1576	CDD:188976	21/68 (31%)
ph-p	NP_476871.2	SAM	1511..1576	CDD:197735	20/65 (31%)
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723	15/102 (15%)
		MBT	929..1028	CDD:214723	14/103 (14%)
		MBT	1038..1130	CDD:214723	19/99 (19%)
		SAM_PNT	1279..1366	CDD:280377	25/90 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453491
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840