DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ph-p and phc2b

DIOPT Version :9

Sequence 1:	NP_476871.2	Gene:	ph-p / 31181	FlyBaseID:	FBgn0004861	Length:	1589	Species:	Drosophila melanogaster
Sequence 2:	NP_957496.3	Gene:	phc2b / 394177	ZFINID:	ZDB-GENE-040426-1113	Length:	890	Species:	Danio rerio

Alignment Length:	980	Identity:	252/980 - (25%)
Similarity:	381/980 - (38%)	Gaps:	224/980 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   710 IGQVAGQNKVVGHLTTVQQQQQATNLQQVVNAAGNKMVVMSTTGTPITLQNGQTLHAATAAGVDK 774
            :.|...:...|.|.....:.:|:|......:..|......::|||  |..:..:..::|::....
Zfish    21 VWQRGSRGSKVKHRGGTMEGEQSTPAASASSTTGTSTSTTNSTGT--TSASTASTASSTSSSTSS 83

  Fly   775 QQQ---QLQLF------QKQQILQQQQMLQQQIAAIQMQQQQAAVQAQQQQQQQVSQQQQVNAQQ 830
            .:|   |:.::      |..|::||....|...||..:||..||.|.....|....|||.::..|
Zfish    84 ARQAVPQISVYSGIPDRQTVQVIQQALNRQPSTAAQYLQQMYAAQQQHLMLQTAALQQQHLSTAQ 148

  Fly   831 QQAVAQQQQAVAQAQQQQREQQQQVAQAQAQHQQALANATQQILQVAPNQFITSHQ--------- 886
            .|::|..||| :.|..:|...|...:..|:...|...|.|   ...|..|.|:..|
Zfish   149 LQSLAAVQQA-SLAAGRQSSNQNGTSSTQSGSSQTTINLT---TSPAAAQLISRAQSVNSAPSGI 209

  Fly   887 QQQQQQLHNQLIQQQLQQQAQAQVQAQVQAQAQQQQQQREQQQNIIQQIVVQQSGATSQQTSQQQ 951
            .||...|.|.........|||..::||:           .||.|::.  |.:..|
Zfish   210 SQQAVLLGNASSSTLTASQAQMYLRAQM-----------AQQSNLVH--VARSLG---------- 251

  Fly   952 QHHQSGQLQLSSVPFSVSSSTTPAGIATSSALQAALSASGAIFQTAKPGTCSSSSPTSSVVTITN 1016
                      .:||  :||....|..||.:|||:..:.:.        .|.|:|:...::....:
Zfish   252 ----------RAVP--LSSQLILAPTATVTALQSDTNTTN--------NTQSASAQVQNLALRNH 296

  Fly  1017 Q--SSTPLVTSSTVASIQQA----------QTQSAQVHQHQQLISATIAGGTQQQPQGPPSLTPT 1069
            |  ||||..|.....|::|.          :|.|......:..::|..:.|.::..:|...:.
Zfish   297 QGVSSTPQATGLQALSLKQTPVSIQPTPLIKTPSQSTGAGKNNLNAASSDGVKKAEEGQTEMK-- 359

  Fly  1070 TNPILAMTSMMNATVGHLSTAP--------------PVTVSVTSTAVTSSPGQLVLLSTASSGGG 1120
                 |:....|.:..|...||              |....:...|..:|..|..||.|||
Zfish   360 -----AVNMSRNVSSSHPLIAPAYAQIQPQALIKQQPQQFVIQPQATPTSRSQPQLLQTAS---- 415

  Fly  1121 GSIPATPTKET-----PSKGPTAT---LVPIGSPKTPVSGKDTCTTPKSSTPATVSASVEASSST 1177
                ..|.::|     ||...|:|   ::|: .||..:..:.:..|.:    ||:..|. .|...
Zfish   416 ----IQPHQQTASLGIPSSAQTSTVTGIIPV-LPKPALHNQGSAQTQQ----ATIFHST-VSHHA 470

  Fly  1178 GEALSNGDASDRSSTPSKGATTPTSKQSNAAVQ---------------PPSSTTPNSVS-GKEEP 1226
            ..||::..|.....|.......|...|::...|               ||....|::.: |.:.|
Zfish   471 HTALAHAKAQPVQLTAINLQIQPAQNQASRLAQDDKEKPTSLVLREICPPVQIHPSTTTQGTDPP 535

  Fly  1227 KLATCGSLTSATSTSTTTTITNG-IGVARTTASTAVSTASTTTTSSGTFITSCTSTTTTTTSSIS 1290
            :       .|...|...|:.|.| :..||......::::.|:..||.....:....||      .
Zfish   536 E-------QSKADTVNATSQTQGSVETAREPTGAQLTSSMTSAVSSEPPPAAVMGNTT------Q 587

  Fly  1291 NGSKDLPKAMIKPNVLTHVIDGFIIQEANEPFPVTRQRYADKDVSDEPPKKKATM----QEDIKL 1351
            ||....|:|::||:||||||:||:|||..|||||.|     ..|:.|.|||..|.    .|....
Zfish   588 NGENKPPQAIVKPHVLTHVIEGFVIQEGAEPFPVER-----PPVAAESPKKPDTQLPSDPEKTAS 647

  Fly  1352 SGIASAPGSD------------------MVACEQCGKMEHKAKLKR-KRYCSPGCSRQAKNGIGG 1397
            |...||..||                  .:.||.||.::...|.|| ||:||..|:::.
Zfish   648 SNSLSATNSDTEEAGQQDTRVEEETEKPKLTCELCGWVDFAHKFKRSKRFCSMVCAKRY------ 706

  Fly  1398 VGSGETNGLGTGGIVGVDAMALVDRLDE---------AMAEEKMQTEATPKLSESFPILGASTEV 1453
                ..:.....|:...|.....:::::         ...|.|.|     :||.|....|.|...
Zfish   707 ----SVSCTKRVGLFRPDRTKSTNQINQWRRRRSHSPRGREAKKQ-----RLSVSQQSQGESISS 762

  Fly  1454 PPMSLPVQAAISAPSPLAMPLGSPLSVALPTLAPLSVVTSGAAPKSSEV--NGTDRPPISS---- 1512
            |..|.|.|.. |:|.       |.:|......:|||..:||.......|  |..:..|:.|
Zfish   763 PLQSQPSQGE-SSPC-------SDISSYEEATSPLSAASSGPVVSQGVVAANEPEELPLLSQHFL 819

  Fly  1513 ------WSVDDVSNFIRELPGCQDYVDDFIQQEIDGQALLLLKEKHLVNAMGMKLGPALKIVAKV 1571
                  |:|.:|..|||.|||||:..|:|..|||||||||||||.||::||.:||||||||.|::
Zfish   820 PCDPTKWNVQEVFEFIRSLPGCQEIADEFRAQEIDGQALLLLKEDHLMSAMNIKLGPALKIFARI 884

  Fly  1572 ESIKE 1576
            ..:|:
Zfish   885 NMLKD 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ph-p	NP_476871.2	SAM_Ph1,2,3	1508..1576	CDD:188976	41/77 (53%)
ph-p	NP_476871.2	SAM	1511..1576	CDD:197735	40/74 (54%)
phc2b	NP_957496.3	TFIIA	389..>554	CDD:281188	40/185 (22%)
		PHC2_SAM_assoc	708..820	CDD:293222	27/124 (22%)
		SAM_Ph1,2,3	822..889	CDD:188976	39/66 (59%)
		SAM	823..890	CDD:197735	40/67 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594058
Domainoid	1	1.000	88	1.000	Domainoid score	I7895
eggNOG	1	0.900	-	-		E1_28JS2
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	192	1.000	Inparanoid score	I3848
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6612
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.850