DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ph-p and Phc1

DIOPT Version :9

Sequence 1:	NP_476871.2	Gene:	ph-p / 31181	FlyBaseID:	FBgn0004861	Length:	1589	Species:	Drosophila melanogaster
Sequence 2:	XP_006237362.1	Gene:	Phc1 / 312690	RGDID:	1309203	Length:	1045	Species:	Rattus norvegicus

Alignment Length:	1522	Identity:	354/1522 - (23%)
Similarity:	500/1522 - (32%)	Gaps:	581/1522 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 PSTPNRPSAPSTPNTNCNSIARHTS-------LTLEKAQNP----GQQVAATTTVPLQISPEQLQ 209
            |..|.|...|......    :.|.|       :..|..||.    |...:..::.|      |:.
  Rat     3 PQPPRRVQRPGLMGLE----SEHHSWGPWNAIMETESEQNSSSTNGSSSSGASSRP------QIA 57

  Fly   210 QFYASNPYAIQVKQEFPTHTTSGSGTELKHATNIMEVQQQLQLQQQLSEAN-----GGGAASAGA 269
            |.......|:|..|            .|:...|..:...|..||||||.|.     ....|:..|
  Rat    58 QMSLYERQAVQALQ------------ALQRQPNAAQYFHQFMLQQQLSNAQLHSLAAVQQATIAA 110

  Fly   270 GGAASPANSQQSQQQ----QHSTAISTMSPMQLAAATGGVGGDWTQGRTVQLMQPSTSFLYPQMI 330
            ...||..||..:|||    |.|..::|.|..||.:            |:..:..||.:.| .|.:
  Rat   111 SRQASSPNSSTAQQQTATTQASINLATTSAAQLIS------------RSQSVSSPSATTL-TQSV 162

  Fly   331 VSGNLLHPGGLGQQPIQVITAGKPFQGNGPQMLTTTTQN---AKQMIGGQAGFAGGNYATCIPTN 392
            :.||...| .|.|...|:..  :|..||..|:..|..:|   |.|:|
  Rat   163 LLGNTTSP-PLNQSQAQMYL--RPQLGNLLQVNRTLGRNVPLASQLI------------------ 206

  Fly   393 HNQSPQTVLFSPMNVISPQQQQNLLQSMAAAAQQQQLTQQQQ---QFNQQQQQQLTQQQQQLTAA 454
                                   |:.:.|.||.||::...|.   ..:..|.|.|..:.||
  Rat   207 -----------------------LMPNGAVAAVQQEVPPAQSPGVHADADQVQNLAVRNQQ---- 244

  Fly   455 LAKVGVDAQGKLAQKVVQKVTTTSSAVQAATGPGSTGSTQTQQVQQVQQQQQQTTQTTQQCVQVS 519
                                       .:|.||...|||| :.:..........:|.:.|.:.|:
  Rat   245 ---------------------------ASAQGPQIPGSTQ-KAIPPGASPVSGLSQASSQALAVA 281

  Fly   520 QSTLPVGVGGQSVQTAQLLNAGQAQQMQIPWFLQNAAGLQ-PFGPNQIILR-----NQPDGTQGM 578
            |::   |..|||:..:|   ||......:|..:....|.| |.|..|:...     |.|....|:
  Rat   282 QAS---GASGQSLNLSQ---AGGGSGNSLPGSMGPGGGGQAPGGLGQLPSSGLAGGNCPRKGTGV 340

  Fly   579 FIQQQPATQTLQTQQNQIIQCNVTQTPTKARTQLDALAPKQQQQQQQVGTTNQTQQQQLAVATAQ 643
             :|..||.||:...|.                                   :||:.:..|...|:
  Rat   341 -VQPLPAAQTVTVSQG-----------------------------------SQTEAESAAAKKAE 369

  Fly   644 LQQQQQQLTAAALQRPGAPVMPHNGTQVRPASSVSTQTAQNQSLLKAKMRNKQQPVRPALATLKT 708
            .....||.....|.|...|                   |.:|:|:.:....:.||
  Rat   370 GDGSSQQSVGMNLTRTATP-------------------APSQTLISSATYTQIQP---------- 405

  Fly   709 EIGQVAGQNKVVGHLTTVQQQQQATNLQQVVNAAGNKMVVMSTTGTPITLQNGQTLHAATAAGVD 773
                         | :.:||||| .:|||       |.||:
  Rat   406 -------------H-SLIQQQQQ-IHLQQ-------KQVVI------------------------ 424

  Fly   774 KQQQQLQLFQKQQILQQQQMLQQQIAAIQMQQQQAAVQAQQQQQQQVSQQQQVNAQQQQAVAQQQ 838
              |||:.:..:||...:|..|......:|:        ||||||||..||||          |||
  Rat   425 --QQQIAIHHQQQFQHRQSQLLHTATHLQL--------AQQQQQQQQQQQQQ----------QQQ 469

  Fly   839 QAVAQAQQQQREQQQQVAQAQAQHQQALANATQQILQVAPNQFITSHQQQQQQQLHNQLIQQQLQ 903
            |     ||||::||||        |||...|..|..||.|.|.:...|.|||
  Rat   470 Q-----QQQQQQQQQQ--------QQATTLAAPQPPQVPPTQQVPPSQSQQQ------------- 508

  Fly   904 QQAQAQVQAQVQAQAQQQQQQREQQQNIIQQIVVQQSGATSQQTSQQQQHHQSGQLQLSSVPFSV 968
                                        .|.:|||.                    .|.|.|.|:
  Rat   509 ----------------------------AQTLVVQP--------------------MLQSSPLSL 525

  Fly   969 SSSTTPAGIATSSALQAALSASGAIFQTAKPGTCSSSSPTSSVVTITNQSSTPLVTSSTVASIQQ 1033
            ....||                       ||             .|..||..|      ||.|:.
  Rat   526 PPEPTP-----------------------KP-------------PIPIQSKPP------VAPIKP 548

  Fly  1034 AQTQSAQVHQHQQLISATIAGGTQQQPQGPPSLTPTTNPILAMTSMMNATVGHLSTAPPVTVSVT 1098
            .|..:|:       :|||    .|..|..|..:..|..|..|....:.  :..|:.|.|.:..:.
  Rat   549 PQLGAAK-------MSAT----QQPPPHIPVQVVGTRQPGTAQAQALG--LAQLAAAVPTSRGMP 600

  Fly  1099 STAVTSSPGQLVLLST-ASSGGGGSIPATPTKETPSKGPTATLVPIGSPKTPVSGKDTCTTP-KS 1161
            ...   .|||..|.|: .||...|::...|    |:.....||.|:......|.|..|.::| .:
  Rat   601 GAV---QPGQAHLASSQPSSQAPGALQECP----PALATGMTLAPVQGTAHVVKGGPTASSPVVA 658

  Fly  1162 STPA--------------TVSASVEASSSTGEALSNGDASDRSSTPSKGATTPTSKQSNAAVQPP 1212
            ..||              |::...:|.|.          .:|....:.|:..|| |.|.||..|.
  Rat   659 QVPAAFYMQSVHLPGKAQTLAVKRKAESE----------EEREDLSALGSVLPT-KASPAAESPK 712

  Fly  1213 SSTTPNSVSGKEEPKLATCGSLTSATSTSTTTTITNGIGVARTTASTAVSTASTTTTSSGTFITS 1277
            .....||:..|.||    ..||.                 |....|..|:.|.|
  Rat   713 VIEEKNSLVEKAEP----VASLN-----------------ANPPNSDLVALAPT----------- 745

  Fly  1278 CTSTTTTTTSSISN--GSKDLPKAMIKPNVLTHVIDGFIIQEANEPFPVTRQRY---ADKDVSDE 1337
             .|....|.:.:|.  |....|:|::||.:|||:|:||:|||..|||||...::   .:|.:...
  Rat   746 -PSAPPPTLALVSRQMGDSKPPQAIVKPQILTHIIEGFVIQEGAEPFPVGCSQFLKETEKPLPAG 809

  Fly  1338 PPKKKATMQEDIKLSGIASAPGSD----MVACEQCGKMEHKAKLK-RKRYCS--------PGCSR 1389
            .|......|....|.|.:.....|    ::.||.|||.....:.: .||:||        ..||.
  Rat   810 LPTGLNESQSGGPLGGDSPCVDLDKKANLLKCEYCGKYAPAEQFRGSKRFCSMTCAKRYNVSCSH 874

  Fly  1390 QAKNGIGGVGSGETNGLGTGGIVGVDAMALVDRLDEAMAEEKMQ--TEAT--------PKLSES- 1443
            |.:                                  :..:||:  .||:        |:.|.|
  Rat   875 QFR----------------------------------LKRKKMKEFQEASYARVRRRGPRRSSSD 905

  Fly  1444 ---FPILG--------ASTEVPPMSLPVQAAISAPSPLAM-------PLGSPLSVALPTLAPLSV 1490
               ..|.|        :|......|.....:.::|.||::       .||:.::
  Rat   906 IARAKIQGKRHRGQEDSSRGSDNSSYDEALSPTSPGPLSVRAGHGERDLGNTIT----------- 959

  Fly  1491 VTSGAAPKSSEVNGTDRPPI------SSWSVDDVSNFIRELPGCQDYVDDFIQQEIDGQALLLLK 1549
                 .|.:.|:.|.:  |:      |.|||::|..||..|.|||:..::|..||||||||||||
  Rat   960 -----TPSTPELQGIN--PVFLSSNPSQWSVEEVYEFIASLQGCQEIAEEFRSQEIDGQALLLLK 1017

  Fly  1550 EKHLVNAMGMKLGPALKIVAKVESIKE 1576
            |:||::||.:||||||||.||:..:||
  Rat  1018 EEHLMSAMNIKLGPALKICAKINVLKE 1044

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ph-p	NP_476871.2	SAM_Ph1,2,3	1508..1576	CDD:188976	40/73 (55%)
ph-p	NP_476871.2	SAM	1511..1576	CDD:197735	39/64 (61%)
Phc1	XP_006237362.1	zf-FCS	833..868	CDD:283998	10/34 (29%)
		PHC2_SAM_assoc	869..975	CDD:293222	23/157 (15%)
		SAM_Ph1,2,3	976..1044	CDD:188976	39/67 (58%)
		SAM	978..1045	CDD:197735	41/67 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	128	1.000	Domainoid score	I5189
eggNOG	1	0.900	-	-		E1_28JS2
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	212	1.000	Inparanoid score	I3566
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9024
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12247
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.920