Protein Alignment ph-p and Phc1

DIOPT Version :10

• Sequence 1: NP_476871.2
• Gene: ph-p / 31181
• FlyBaseID: FBgn0004861
• Length: 1589
• Species: Drosophila melanogaster
• Sequence 2: NP_001101356.1
• Gene: Phc1 / 312690
• RGDID: 1309203
• Length: 1042
• Species: Rattus norvegicus
• Alignment Length: 1515
• Identity: 352/1515 - (23%)
• Similarity: 501/1515 - (33%)
• Gaps: 570/1515 - (37%)

  Fly   156 PSTPNRPSAPSTPNTNCNSIARHTSLTLEKAQNP----GQQVAATTTVPLQISPEQLQQFYASNP 216
            |..|.|...|...:.:.:....:..:..|..||.    |...:..::.|      |:.|......
  Rat     3 PQPPRRVQRPGLESEHHSWGPWNAIMETESEQNSSSTNGSSSSGASSRP------QIAQMSLYER 61

  Fly   217 YAIQVKQEFPTHTTSGSGTELKHATNIMEVQQQLQLQQQLSEAN-----GGGAASAGAGGAASPA 276
            .|:|..|            .|:...|..:...|..||||||.|.     ....|:..|...||..
  Rat    62 QAVQALQ------------ALQRQPNAAQYFHQFMLQQQLSNAQLHSLAAVQQATIAASRQASSP 114

  Fly   277 NSQQSQQQ----QHSTAISTMSPMQLAAATGGVGGDWTQGRTVQLMQPSTSFLYPQMIVSGNLLH 337
            ||..:|||    |.|..::|.|..||.:            |:..:..||.:.| .|.::.||...
  Rat   115 NSSTAQQQTATTQASINLATTSAAQLIS------------RSQSVSSPSATTL-TQSVLLGNTTS 166

  Fly   338 PGGLGQQPIQVITAGKPFQGNGPQMLTTTTQN---AKQMIGGQAGFAGGNYATCIPTNHNQSPQT 399
            | .|.|...|:..  :|..||..|:..|..:|   |.|:|
  Rat   167 P-PLNQSQAQMYL--RPQLGNLLQVNRTLGRNVPLASQLI------------------------- 203

  Fly   400 VLFSPMNVISPQQQQNLLQSMAAAAQQQQLTQQQQ---QFNQQQQQQLTQQQQQLTAALAKVGVD 461
                            |:.:.|.||.||::...|.   ..:..|.|.|..:.||
  Rat   204 ----------------LMPNGAVAAVQQEVPPAQSPGVHADADQVQNLAVRNQQ----------- 241

  Fly   462 AQGKLAQKVVQKVTTTSSAVQAATGPGSTGSTQTQQVQQVQQQQQQTTQTTQQCVQVSQSTLPVG 526
                                .:|.||...|||| :.:..........:|.:.|.:.|:|::   |
  Rat   242 --------------------ASAQGPQIPGSTQ-KAIPPGASPVSGLSQASSQALAVAQAS---G 282

  Fly   527 VGGQSVQTAQLLNAGQAQQMQIPWFLQNAAGLQ-PFGPNQIILR-----NQPDGTQGMFIQQQPA 585
            ..|||:..:|   ||......:|..:....|.| |.|..|:...     |.|....|: :|..||
  Rat   283 ASGQSLNLSQ---AGGGSGNSLPGSMGPGGGGQAPGGLGQLPSSGLAGGNCPRKGTGV-VQPLPA 343

  Fly   586 TQTLQTQQNQIIQCNVTQTPTKARTQLDALAPKQQQQQQQVGTTNQTQQQQLAVATAQLQQQQQQ 650
            .||:...|.                                   :||:.:..|...|:.....||
  Rat   344 AQTVTVSQG-----------------------------------SQTEAESAAAKKAEGDGSSQQ 373

  Fly   651 LTAAALQRPGAPVMPHNGTQVRPASSVSTQTAQNQSLLKAKMRNKQQPVRPALATLKTEIGQVAG 715
            .....|.|...|                   |.:|:|:.:....:.||
  Rat   374 SVGMNLTRTATP-------------------APSQTLISSATYTQIQP----------------- 402

  Fly   716 QNKVVGHLTTVQQQQQATNLQQVVNAAGNKMVVMSTTGTPITLQNGQTLHAATAAGVDKQQQQLQ 780
                  | :.:||||| .:|||       |.||:                          |||:.
  Rat   403 ------H-SLIQQQQQ-IHLQQ-------KQVVI--------------------------QQQIA 426

  Fly   781 LFQKQQILQQQQMLQQQIAAIQMQQQQAAVQAQQQQQQQVSQQQQVNAQQQQAVAQQQQAVAQAQ 845
            :..:||...:|..|......:|:        ||||||||..||||          ||||     |
  Rat   427 IHHQQQFQHRQSQLLHTATHLQL--------AQQQQQQQQQQQQQ----------QQQQ-----Q 468

  Fly   846 QQQREQQQQVAQAQAQHQQALANATQQILQVAPNQFITSHQQQQQQQLHNQLIQQQLQQQAQAQV 910
            |||::||||        |||...|..|..||.|.|.:...|.|||
  Rat   469 QQQQQQQQQ--------QQATTLAAPQPPQVPPTQQVPPSQSQQQ-------------------- 505

  Fly   911 QAQVQAQAQQQQQQREQQQNIIQQIVVQQSGATSQQTSQQQQHHQSGQLQLSSVPFSVSSSTTPA 975
                                 .|.:|||.                    .|.|.|.|:....||
  Rat   506 ---------------------AQTLVVQP--------------------MLQSSPLSLPPEPTP- 528

  Fly   976 GIATSSALQAALSASGAIFQTAKPGTCSSSSPTSSVVTITNQSSTPLVTSSTVASIQQAQTQSAQ 1040
                                  ||             .|..||..|      ||.|:..|..:|:
  Rat   529 ----------------------KP-------------PIPIQSKPP------VAPIKPPQLGAAK 552

  Fly  1041 VHQHQQLISATIAGGTQQQPQGPPSLTPTTNPILAMTSMMNATVGHLSTAPPVTVSVTSTAVTSS 1105
                   :|||    .|..|..|..:..|..|..|....:.  :..|:.|.|.:..:....   .
  Rat   553 -------MSAT----QQPPPHIPVQVVGTRQPGTAQAQALG--LAQLAAAVPTSRGMPGAV---Q 601

  Fly  1106 PGQLVLLST-ASSGGGGSIPATPTKETPSKGPTATLVPIGSPKTPVSGKDTCTTP-KSSTPA--- 1165
            |||..|.|: .||...|::...|    |:.....||.|:......|.|..|.::| .:..||
  Rat   602 PGQAHLASSQPSSQAPGALQECP----PALATGMTLAPVQGTAHVVKGGPTASSPVVAQVPAAFY 662

  Fly  1166 -----------TVSASVEASSSTGEALSNGDASDRSSTPSKGATTPTSKQSNAAVQPPSSTTPNS 1219
                       |::...:|.|.          .:|....:.|:..|| |.|.||..|......||
  Rat   663 MQSVHLPGKAQTLAVKRKAESE----------EEREDLSALGSVLPT-KASPAAESPKVIEEKNS 716

  Fly  1220 VSGKEEPKLATCGSLTSATSTSTTTTITNGIGVARTTASTAVSTASTTTTSSGTFITSCTSTTTT 1284
            :..|.||    ..||.                 |....|..|:.|.|            .|....
  Rat   717 LVEKAEP----VASLN-----------------ANPPNSDLVALAPT------------PSAPPP 748

  Fly  1285 TTSSISN--GSKDLPKAMIKPNVLTHVIDGFIIQEANEPFPVTRQRY---ADKDVSDEPPKKKAT 1344
            |.:.:|.  |....|:|::||.:|||:|:||:|||..|||||...::   .:|.:....|.....
  Rat   749 TLALVSRQMGDSKPPQAIVKPQILTHIIEGFVIQEGAEPFPVGCSQFLKETEKPLPAGLPTGLNE 813

  Fly  1345 MQEDIKLSGIASAPGSD----MVACEQCGKMEHKAKLK-RKRYCS--------PGCSRQAKNGIG 1396
            .|....|.|.:.....|    ::.||.|||.....:.: .||:||        ..||.|.:
  Rat   814 SQSGGPLGGDSPCVDLDKKANLLKCEYCGKYAPAEQFRGSKRFCSMTCAKRYNVSCSHQFR---- 874

  Fly  1397 GVGSGETNGLGTGGIVGVDAMALVDRLDEAMAEEKMQ--TEAT--------PKLSES----FPIL 1447
                                          :..:||:  .||:        |:.|.|    ..|.
  Rat   875 ------------------------------LKRKKMKEFQEASYARVRRRGPRRSSSDIARAKIQ 909

  Fly  1448 G--------ASTEVPPMSLPVQAAISAPSPLAM-------PLGSPLSVALPTLAPLSVVTSGAAP 1497
            |        :|......|.....:.::|.||::       .||:.::                .|
  Rat   910 GKRHRGQEDSSRGSDNSSYDEALSPTSPGPLSVRAGHGERDLGNTIT----------------TP 958

  Fly  1498 KSSEVNGTDRPPI------SSWSVDDVSNFIRELPGCQDYVDDFIQQEIDGQALLLLKEKHLVNA 1556
            .:.|:.|.:  |:      |.|||::|..||..|.|||:..::|..|||||||||||||:||::|
  Rat   959 STPELQGIN--PVFLSSNPSQWSVEEVYEFIASLQGCQEIAEEFRSQEIDGQALLLLKEEHLMSA 1021

  Fly  1557 MGMKLGPALKIVAKVESIKE 1576
            |.:||||||||.||:..:||
  Rat  1022 MNIKLGPALKICAKINVLKE 1041

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ph-p	NP_476871.2	DUF5585	1015..>1232	CDD:465521	56/232 (24%)
		SAM_Ph1,2,3	1508..1576	CDD:188976	40/73 (55%)
Phc1	NP_001101356.1	PHC2_SAM_assoc	866..973	CDD:465202	23/158 (15%)
		SAM_Ph1,2,3	973..1041	CDD:188976	39/67 (58%)