Protein Alignment ph-p and Phc3

DIOPT Version :9

• Sequence 1: NP_476871.2
• Gene: ph-p / 31181
• FlyBaseID: FBgn0004861
• Length: 1589
• Species: Drosophila melanogaster
• Sequence 2: XP_006535530.1
• Gene: Phc3 / 241915
• MGIID: 2181434
• Length: 1009
• Species: Mus musculus
• Alignment Length: 1176
• Identity: 269/1176 - (22%)
• Similarity: 425/1176 - (36%)
• Gaps: 333/1176 - (28%)

  Fly   561 FGPNQIILRNQP-DGTQGMFIQQQPATQTLQTQQN------------------QIIQCNVTQTPT 606
            |..:...:.::| .||..........|.|:.|..:                  |:||..:.:.|:
Mouse     6 FKDHSTAMDSEPSSGTSVSTTASSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPS 70

  Fly   607 KARTQLDALAPKQQQQQQQVGTTNQTQQQQLAVATAQLQQQ----QQQLTAAALQ---RPGAPVM 664
            .|          .|..||...    .|||.|.:.||.||||    .|..:.||:|   ..|.|
Mouse    71 SA----------AQYLQQMYA----AQQQHLMLHTAALQQQHLSSSQLQSLAAVQASLSSGRP-- 119

  Fly   665 PHNGTQVRPASSVSTQTAQNQ-SLLK-----AKMRNKQQPVRPALATLKTEIGQVAGQNKVVGHL 723
                 ...|..||:.|::.:| |:|.     |::.|:.|       |..:..|.:..|..::|..
Mouse   120 -----STSPTGSVTQQSSMSQTSILSASPAPAQLMNRSQ-------TSSSTSGSITQQTMLLGST 172

  Fly   724 T---TVQQQQQATNLQQV-------VNAAGNKMVVMSTTGTPITLQNGQTLHAATAAGVDKQQQQ 778
            :   |..|.|.....|.:       |.|..:.:.|:|::.:|       :..:|.|
Mouse   173 SPTLTASQAQMYLRAQMLIFTPATTVAAVQSDIPVVSSSPSP-------SCQSAAA--------- 221

  Fly   779 LQLFQKQQILQQQQMLQQQIAAIQMQQQQAAVQAQQQQQQQVSQQQQVNAQQQQAVAQQQQAVAQ 843
                              |:..:.::.|:..|.:..|.....|..|    .|...:...:..|..
Mouse   222 ------------------QVQNLTLRSQKLGVLSSSQNGSPKSAGQ----TQSLTICHNKTTVTS 264

  Fly   844 AQQQQREQQQQVAQAQAQHQQALANA---TQQILQ-VAPNQF--ITSHQQQQQQQL--------- 893
            ::..||:...:..:..:...::.:.|   |..|.| :||..:  |..|...:.||:
Mouse   265 SKISQRDPSPESKKGGSPGLESRSTAVTRTSSIHQLIAPASYSPIQPHSLIKHQQIPLHSPPPKV 329

  Fly   894 -HNQLIQQQLQQQAQAQVQAQVQAQAQQQQQQREQQQNIIQQIVVQQSGATSQQTSQQQQHHQSG 957
             |:||:.||.|||.|     .:..|:..|.....|     ..|.:...|.:...::.|.||  ..
Mouse   330 SHHQLLLQQQQQQIQ-----PITLQSPSQDPPPSQ-----HCIPLPNHGLSPAPSNAQPQH--CS 382

  Fly   958 QLQLSSVPFSVSSSTTPAGIATSSALQAALSASGAIFQTAKPGTCSSSSPTSSVVTITNQSSTPL 1022
            .:|....|.:||.:             .|.||..::..:..|....|.|||..:.........||
Mouse   383 PVQSHPPPLTVSPN-------------QAQSAQQSVVVSPPPPHSPSQSPTIIIHPQALIQPHPL 434

  Fly  1023 VTSS--TVASIQQAQTQSAQVHQHQQLISATIAGGTQQQPQGPPSLTPTTNPILAMTSMMNATVG 1085
            |:|:  |..::|||...  ||....||              ..||..|
Mouse   435 VSSALQTGPNLQQAAAD--QVQSTAQL--------------NLPSHLP----------------- 466

  Fly  1086 HLSTAPPVTVSVTSTAVTSSPGQLVLLSTASSGGGGSIPATPTKETPSKGPTATLVPIGSPKTPV 1150
             |..:|.|.:.....:...||||.::              :||.........::.:||.:|
Mouse   467 -LPASPVVHIGPVQQSALVSPGQQMV--------------SPTSHQQYSALQSSPIPIATP---- 512

  Fly  1151 SGKDTCTTPKSSTPATVSASVEASSSTGEALSNGD---------------ASDRSSTPSKGATTP 1200
              .....:|.:..|.....|:::.....|.||.|.               |......|.:....|
Mouse   513 --PQMSASPPAQLPPLPLQSMQSLQVQPEILSQGQVLVQNALVSEEELPAAEALVQLPFQTLPPP 575

  Fly  1201 TSKQSNAAVQPPSSTTP----------------------NSVSGKEEPKLA-TCGSL--TSATST 1240
            .:...|..||||:...|                      ..|..:|.|:.: .|..:  |....|
Mouse   576 QTVAVNLQVQPPAPVDPPVGMHLNQCHLHKVFSLKVYQVEDVCEEEMPEESDECARMDRTPPPPT 640

  Fly  1241 STTTTITNGIG-----------------VARTTASTAVSTASTTTTSSGT--FITSCTSTTTTTT 1286
            .:...:|.|.|                 ||..:||...|.:..|..|:..  .:....||.:::|
Mouse   641 LSPAAVTVGRGEDLTSEHPLLEQVELPAVASVSASVIKSPSDPTHASAPAPPLLIPAASTRSSST 705

  Fly  1287 SSISNGSKDL----PKAMIKPNVLTHVIDGFIIQEANEPFPVTRQRYADKDVSDEPPKKKATMQ- 1346
             |:::.:..|    |:|::||.:|||||:||:|||..|||||:|...    :.::|.||:..:.
Mouse   706 -SLASSTPSLENKPPQAIVKPQILTHVIEGFVIQEGLEPFPVSRSSL----LIEQPVKKRPLLDN 765

  Fly  1347 ---------------------------EDIKLSGIASAPGSDMVACEQCGKMEHKAK-LKRKRYC 1383
                                       ||:..........|:::.||.||||.:..: |:.||:|
Mouse   766 QVVNSVCVQPELQNNTKHADNSSDTEIEDMMAEETLEEMDSELLKCEFCGKMGYPNEFLRSKRFC 830

  Fly  1384 SPGCSRQAKNGIGGVGSGETNGLGTGGIVGVDAMALVDRLDEAMAEEKMQTEATPKLSESFPILG 1448
            :..|:::.     .|...:...|....          .:.|......:.:..:.|:        |
Mouse   831 TMSCAKRY-----NVSCSKKFALSRWN----------RKPDNQSLGHRGRRPSGPE--------G 872

  Fly  1449 ASTEVPPMSLPVQ--------AAISAPSPLAMPLGSPLSVALPTLAPLSVVTSGAAPKSSEVNGT 1505
            |:.|.....||:.        |:...|.|.||...............|..|.....|::|::...
Mouse   873 AAREHILRQLPITYPSAEEDVASHEDPVPSAMTTRLRRQSERERERELRDVRIRKMPENSDLLPV 937

  Fly  1506 DRPPISSWSVDDVSNFIRELPGCQDYVDDFIQQEIDGQALLLLKEKHLVNAMGMKLGPALKIVAK 1570
            .:...|.|:||||..||..||||||..|:|..|||||||||||||.||::||.|||||||||.|:
Mouse   938 AQTEPSIWTVDDVWAFIHSLPGCQDVADEFRAQEIDGQALLLLKEDHLMSAMNMKLGPALKICAR 1002

  Fly  1571 VESIKE 1576
            :.|:|:
Mouse  1003 INSLKD 1008

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ph-p	NP_476871.2	SAM_Ph1,2,3	1508..1576	CDD:188976	44/67 (66%)
		SAM	1511..1576	CDD:197735	44/64 (69%)
Phc3	XP_006535530.1	Atrophin-1	224..>595	CDD:367360	91/453 (20%)
		PAT1	<352..>516	CDD:370676	46/237 (19%)
		SAM_Ph1,2,3	940..1008	CDD:188976	44/67 (66%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848557
Domainoid	1	1.000	91	1.000	Domainoid score	I7659
eggNOG	1	0.900	-	-		E1_28JS2
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7881
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8777
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12247
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4720
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.780