DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ph-p and Phc1

DIOPT Version :9

Sequence 1:	NP_476871.2	Gene:	ph-p / 31181	FlyBaseID:	FBgn0004861	Length:	1589	Species:	Drosophila melanogaster
Sequence 2:	XP_006505561.1	Gene:	Phc1 / 13619	MGIID:	103248	Length:	1040	Species:	Mus musculus

Alignment Length:	1512	Identity:	342/1512 - (22%)
Similarity:	492/1512 - (32%)	Gaps:	566/1512 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 PSTPNRPSAPSTPNTNCNSIARHT------SLTLEKAQNP----GQQVAATTTVPLQISPEQLQQ 210
            |..|.|...|........   ||:      .:..|..||.    |...:..::.|      |:.|
Mouse     3 PQPPRRVQRPGFMGLESE---RHSWGPWNAIMETESEQNSSSTNGSSSSGASSRP------QIAQ 58

  Fly   211 FYASNPYAIQVKQEFPTHTTSGSGTELKHATNIMEVQQQLQLQQQLSEAN-----GGGAASAGAG 270
            .......|:|..|            .|:...|..:...|..||||||.|.     ....|:..|.
Mouse    59 MSLYERQAVQALQ------------ALQRQPNAAQYFHQFMLQQQLSNAQLHSLAAVQQATIAAS 111

  Fly   271 GAASPANSQQSQQQ----QHSTAISTMSPMQLAAATGGVGGDWTQGRTVQLMQPSTSFLYPQMIV 331
            ..||..||..:|||    |.|..::|.|..||.:            |:..:..||.:.| .|.::
Mouse   112 RQASSPNSSTAQQQTATTQASMNLATTSAAQLIS------------RSQSVSSPSATTL-TQSVL 163

  Fly   332 SGNLLHPGGLGQQPIQVITAGKPFQGNGPQMLTTTTQN---AKQMIGGQAGFAGGNYATCIPTNH 393
            .||...| .|.|...|:..  :|..||..|:..|..:|   |.|:|
Mouse   164 LGNTTSP-PLNQSQAQMYL--RPQLGNLLQVNRTLGRNVPLASQLI------------------- 206

  Fly   394 NQSPQTVLFSPMNVISPQQQQNLLQSMAAAAQQQQLTQQQQ---QFNQQQQQQLTQQQQQLTAAL 455
                                  |:.:.|.||.||::...|.   ..:..|.|.|..:.||
Mouse   207 ----------------------LMPNGAVAAVQQEVPPAQSPGVHADADQVQNLAVRNQQ----- 244

  Fly   456 AKVGVDAQGKLAQKVVQKVTTTSSAVQAATGPGSTGSTQTQQVQQVQQQQQQTTQTTQQCVQVSQ 520
                                      .:|.||...|||| :.:..........:||:.|.:.|:|
Mouse   245 --------------------------ASAQGPQMPGSTQ-KAIPPGASPVSGLSQTSSQALAVAQ 282

  Fly   521 STLPVGVGGQSVQTAQLLNAGQAQQMQIPWFLQNAAGLQ-PFGPNQIILRNQPDGT---QGM-FI 580
            ::  .|..|||:..:|   ||......:|..:....|.| |.|..|:.......|:   :|. .:
Mouse   283 AS--SGASGQSLNLSQ---AGGGSGNSLPGSMGPGGGGQAPGGLGQLPSSGLTGGSCPRKGTGVV 342

  Fly   581 QQQPATQTLQTQQNQIIQCNVTQTPTKARTQLDALAPKQQQQQQQVGTTNQTQQQQLAVATAQLQ 645
            |..||.||:...|.                                   :||:.:..|...|:..
Mouse   343 QPLPAAQTVTVSQG-----------------------------------SQTEAESAAAKKAEAD 372

  Fly   646 QQQQQLTAAALQRPGAPVMPHNGTQVRPASSVSTQTAQNQSLLKAKMRNKQQPVRPALATLKTEI 710
            ...||.....|.|...|                   |.:|:|:.:....:.||
Mouse   373 GSGQQSVGMNLTRTATP-------------------APSQTLISSATYTQIQP------------ 406

  Fly   711 GQVAGQNKVVGHLTTVQQQQQATNLQQVVNAAGNKMVVMSTTGTPITLQNGQTLHAATAAGVDKQ 775
                       | :.:||||| .:|||       |.||:
Mouse   407 -----------H-SLIQQQQQ-IHLQQ-------KQVVI-------------------------- 425

  Fly   776 QQQLQLFQKQQILQQQQMLQQQIAAIQMQQQQAAVQAQQQQQQQVSQQQQVNAQQQQAVAQQQQA 840
            |||:.:..:||...:|..|......:|:.|||     |||||||
Mouse   426 QQQIAIHHQQQFQHRQSQLLHTATHLQLAQQQ-----QQQQQQQ--------------------- 464

  Fly   841 VAQAQQQQREQQQQVAQAQAQHQQALANATQQILQVAPNQFITSHQQQQQQQLHNQLIQQQLQQQ 905
                ||||::||||        ||.......|..||.|.|.:...|.|||.|  ..::|..|
Mouse   465 ----QQQQQQQQQQ--------QQGTTLTAPQPPQVPPTQQVPPSQSQQQAQ--TLVVQPML--- 512

  Fly   906 AQAQVQAQVQAQAQQQQQQREQQQNIIQQIVVQQSGATSQQTSQQQQHHQSGQLQLSSVPFSVSS 970
                                                             ||..|.|...|
Mouse   513 -------------------------------------------------QSSPLTLPPEP----- 523

  Fly   971 STTPAGIATSSALQAALSASGAIFQTAKPGTCSSSSPTSSVVTITNQSSTPLVTSSTVASIQQAQ 1035
                                     |:||             .|..||..|      ||.|:..|
Mouse   524 -------------------------TSKP-------------PIPIQSKPP------VAPIKPPQ 544

  Fly  1036 TQSAQVHQHQQLISATIAGGTQQQPQGPPSLTPTTNPILAMTSMMNATVGHLSTAPPVTVSVTST 1100
            ..:|:       :|||    .|..|..|..:..|..|..|....:.  :..|:.|.|....:|..
Mouse   545 LGAAK-------MSAT----QQPPPHIPVQVVGTRQPGSAQAQALG--LAQLAAAVPTPRGITGA 596

  Fly  1101 AVTSSPGQLVLLST--ASSGGGGSIPATPTKETPSKGPTATLVPIGSPKTPVSGKDTCTTP-KSS 1162
            .   .|||..|.|:  :|....|::...|    |:.....||.|:......|.|..|.::| .:.
Mouse   597 V---QPGQAHLASSPPSSQAAPGALQECP----PALAAGMTLAPVQGTAHVVKGGPTASSPVVAQ 654

  Fly  1163 TPATV---SASVEASSSTGEALSNGDASDRSSTPSKGATTPTSKQSNAAVQPPSSTTPNSVSGKE 1224
            .||..   |..:...:.|.......::.:.....|..|:...:|.|.||..|......||:..|.
Mouse   655 VPAAFYMQSVHLPGKAQTLAVKRKAESEEERDDLSALASVLPTKASPAAESPKVIEEKNSLGEKA 719

  Fly  1225 EPKLATCGSLTSATSTSTTTTITNGIGVARTTASTAVSTASTTTTSSGTFITSCTSTTTTTTSSI 1289
            ||    ..||.                 |....|..|:.|.|            .|....|.:.:
Mouse   720 EP----VASLN-----------------ANPPNSDLVALAPT------------PSAPPPTLALV 751

  Fly  1290 SN--GSKDLPKAMIKPNVLTHVIDGFIIQEANEPFPVTRQRY---ADKDVSDEPPKKKATMQEDI 1349
            |.  |....|:|::||.:|||:|:||:|||..|||||...::   ..|.:....|......|...
Mouse   752 SRQMGDSKPPQAIVKPQILTHIIEGFVIQEGAEPFPVGCSQFLKETKKPLQAGLPTGLNESQPSG 816

  Fly  1350 KLSGIASAPG------SDMVACEQCGKMEHKAKLK-RKRYCS--------PGCSRQAKNGIGGVG 1399
            .|.|  .:|.      ::::.||.|||.....:.: .||:||        ..||.|.:
Mouse   817 PLGG--DSPSVELEKKANLLKCEYCGKYAPAEQFRGSKRFCSMTCAKRYNVSCSHQFR------- 872

  Fly  1400 SGETNGLGTGGIVGVDAMALVDRLDEAMAEEKMQ--TEAT--------PKLSES----FPILG-- 1448
                                       :..:||:  .||:        |:.|.|    ..|.|
Mouse   873 ---------------------------LKRKKMKEFQEASYARVRRRGPRRSSSDIARAKIQGKR 910

  Fly  1449 ------ASTEVPPMSLPVQAAISAPSPLAM-------PLGSPLSVALPTLAPLSVVTSGAAPKSS 1500
                  :|......|.....:.::|.||::       .||:.::                .|.:.
Mouse   911 HRGQEDSSRGSDNSSYDEALSPTSPGPLSVRAGHGERDLGNTIT----------------TPSTP 959

  Fly  1501 EVNGTDRPPI------SSWSVDDVSNFIRELPGCQDYVDDFIQQEIDGQALLLLKEKHLVNAMGM 1559
            |:.|.:  |:      |.|||::|..||..|.|||:..::|..|||||||||||||:||::||.:
Mouse   960 ELQGIN--PVFLSSNPSQWSVEEVYEFIASLQGCQEIAEEFRSQEIDGQALLLLKEEHLMSAMNI 1022

  Fly  1560 KLGPALKIVAKVESIKE 1576
            ||||||||.||:..:||
Mouse  1023 KLGPALKICAKINVLKE 1039

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ph-p	NP_476871.2	SAM_Ph1,2,3	1508..1576	CDD:188976	40/73 (55%)
ph-p	NP_476871.2	SAM	1511..1576	CDD:197735	39/64 (61%)
Phc1	XP_006505561.1	PHA03247	<509..639	CDD:223021	44/250 (18%)
		PHC2_SAM_assoc	864..970	CDD:374673	23/157 (15%)
		SAM_Ph1,2,3	971..1039	CDD:188976	39/67 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	126	1.000	Domainoid score	I5390
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	206	1.000	Inparanoid score	I3713
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8777
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12247
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4720
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.090