DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ph-p and SCML2

DIOPT Version :9

Sequence 1:	NP_476871.2	Gene:	ph-p / 31181	FlyBaseID:	FBgn0004861	Length:	1589	Species:	Drosophila melanogaster
Sequence 2:	NP_006080.1	Gene:	SCML2 / 10389	HGNCID:	10581	Length:	700	Species:	Homo sapiens

Alignment Length:	839	Identity:	164/839 - (19%)
Similarity:	271/839 - (32%)	Gaps:	308/839 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   901 QLQQQAQAQVQAQVQAQAQQQQQQREQQQNIIQQIVVQQSGATSQQTSQQQQHHQSGQLQLSSVP 965
            |...:....|:.:.|.:..|......|:.:...:..::::|:.|..:...:|         |.:|
Human     3 QTVNEDSMDVKKENQEKTPQSSTSSVQRDDFHWEEYLKETGSISAPSECFRQ---------SQIP 58

  Fly   966 ----FSVS---SSTTPAGIATSSALQAALSASGAIFQ-------------------TAKP-GTCS 1003
                |.|.   .:..|.. |||..:...:..:||..:                   ..:| |||.
Human    59 PVNDFKVGMKLEARDPRN-ATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCE 122

  Fly  1004 SSS-----PTSSVVTITNQSSTPLVTSSTVASIQQAQTQSAQVHQHQQLISATIAGGTQQQPQGP 1063
            ...     |....:   |.||.|:....|:...:.|              |||:   .:::|..|
Human   123 KEGDLLQPPLGYQM---NTSSWPMFLLKTLNGSEMA--------------SATL---FKKEPPKP 167

  Fly  1064 PSLTPTTNPILAMTSMMNATVGHLSTAPPVTVSVTSTAVTSSPGQLVLLSTASSGGGGSIPAT-- 1126
            |              :.|..||           :...|:......|:..:|.....|..:..|
Human   168 P--------------LNNFKVG-----------MKLEAIDKKNPYLICPATIGDVKGDEVHITFD 207

  Fly  1127 ---PTKETPSKGPTATLVPIGSPKTPVSGKDTCTTPKSSTPATVS-ASVEASSSTGEALSNGDAS 1187
               ...:...|..:..:.|.|..:  ::| |....|.:|.|...: |..|:|.|        :||
Human   208 GWSGAFDYWCKYDSRDIFPAGWCR--LTG-DVLQPPGTSVPIVKNIAKTESSPS--------EAS 261

  Fly  1188 DRS-STPSKGATT---PTSK-QSNAAVQPPSSTT-----------------PNSVSGKEEPKLAT 1230
            ..| .:|.|  ||   ||.: :.::.::||..|.                 ||| ..||:|....
Human   262 QHSMQSPQK--TTLILPTQQVRRSSRIKPPGPTAVPKRSSSVKNITPRKKGPNS-GKKEKPLPVI 323

  Fly  1231 CGSLTSATSTSTTTTITNGIG-----VARTTASTAVSTASTTTTSSGTF---------------- 1274
            |     :||.::..::|...|     ||.......:||........|.|
Human   324 C-----STSAASLKSLTRDRGMLYKDVASGPCKIVMSTVCVYVNKHGNFGPHLDPKRIQQLPDHF 383

  Fly  1275 ------------ITSCTSTTTTTTSSISNGSKDLPKAMIKPN-----VLTHVIDG---------- 1312
                        :.:|......|.:..         ..:||:     |:|...||
Human   384 GPGPVNVVLRRIVQACVDCALETKTVF---------GYLKPDNRGGEVITASFDGETHSIQLPPV 439

  Fly  1313 ----FIIQ--------------EANEPFPVTR-----------QRYADKDVSDEPPKKKATMQ-- 1346
                |.::              .:::||..:|           .:.|.:||::....|::..|
Human   440 NSASFALRFLENFCHSLQCDNLLSSQPFSSSRGHTHSSAEHDKNQSAKEDVTERQSTKRSPQQTV 504

  Fly  1347 --------EDIKLSGIAS------APGSDMVACEQCGKMEHKAKLKRKRYCSPGCSRQAKNGIGG 1397
                    :..|....||      |.||.:...|...:....:.|....|.:|.|
Human   505 PYVVPLSPKLPKTKEYASEGEPLFAGGSAIPKEENLSEDSKSSSLNSGNYLNPAC---------- 559

  Fly  1398 VGSGETNGLGTGGIVGVDAMALVDRLDEAMAEEKMQTEATPKLSESFPILGASTEVPPMSLP--- 1459
                 .|.:.....|..|.                 :.:.|..:.| |::|   ::.|.|.|
Human   560 -----RNPMYIHTSVSQDF-----------------SRSVPGTTSS-PLVG---DISPKSSPHEV 598

  Fly  1460 ---VQAAISAPSPLAMPLGSPLSVALPTLAPLSVVTSGAAPKSSEVNGTDRPPISSWSVDDVSNF 1521
               :|....|||.:|:|..|.|.                       .|..:.| |:||||:|..|
Human   599 KFQMQRKSEAPSYIAVPDPSVLK-----------------------QGFSKDP-STWSVDEVIQF 639

  Fly  1522 IR----ELPGCQDYVDDFIQQEIDGQALLLLKEKHLVNAMGMKLGPALKIVAKVESIKE 1576
            ::    ::.|  ...|.|.|.||||:||.|||...::..||:|||||||:...:|.:||
Human   640 MKHTDPQISG--PLADLFRQHEIDGKALFLLKSDVMMKYMGLKLGPALKLCYYIEKLKE 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ph-p	NP_476871.2	SAM_Ph1,2,3	1508..1576	CDD:188976	31/71 (44%)
ph-p	NP_476871.2	SAM	1511..1576	CDD:197735	30/68 (44%)
SCML2	NP_006080.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		5/29 (17%)
		MBT 1	33..131		17/107 (16%)
		MBT	36..131	CDD:214723	17/104 (16%)
		MBT 2	139..240		24/145 (17%)
		MBT	142..240	CDD:214723	22/142 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..320		20/77 (26%)
		DUF3588	356..465	CDD:288954	12/117 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	466..550		15/83 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	575..594		5/22 (23%)
		SAM_Scm	625..696	CDD:188977	31/73 (42%)
		SAM	628..696	CDD:197735	31/70 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910