DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Unc-76 and FEZ2

DIOPT Version :9

Sequence 1:	NP_001259172.1	Gene:	Unc-76 / 31179	FlyBaseID:	FBgn0040395	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001036013.1	Gene:	FEZ2 / 9637	HGNCID:	3660	Length:	380	Species:	Homo sapiens

Alignment Length:	437	Identity:	140/437 - (32%)
Similarity:	210/437 - (48%)	Gaps:	133/437 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 NCNTLQGGSLIEIGLSDVGLVPGEGAGVGLDGLEKRSLAVGDHVDNFTETFGGSLEDLVNTFDEK 154
            |||          ...:.|...|..||.|.||....:.::                      :||
Human    25 NCN----------ASPEPGAEAGAEAGGGADGFPAPACSL----------------------EEK 57

  Fly   155 ITKCFGNYEENVE----ELAPVQVRSQEEIMNECQMWWTITGNFGNILPIDWSKSYTRQMHMPTL 215
            ::.||...:...|    .:.|:..||   ::...::|..:|.|:||::|:||..|:||.:|:.||
Human    58 LSLCFRPSDPGAEPPRTAVRPITERS---LLQGDEIWNALTDNYGNVMPVDWKSSHTRTLHLLTL 119

  Fly   216 NLGQNHTKQQQQNRNQQQQLHNQSHQAYPHTNGLGSGSGSGLDAQTPGDEFNDLTSEDEAVANDL 280
            ||                                   |..|:......|     ||:||.:...|
Human   120 NL-----------------------------------SEKGVSDSLLFD-----TSDDEELREQL 144

  Fly   281 DMHALILNGLNGDMDDQPIKTVEEVIKEIDDIMDEAESPLDE--PETCD------SEVIEKAREV 337
            |||::|::.:|    |:|:.|.::||:||:::|.|:..|.|:  |...|      .|:....|..
Human   145 DMHSIIVSCVN----DEPLFTADQVIEEIEEMMQESPDPEDDETPTQSDRLSMLSQEIQTLKRSS 205

  Fly   338 LGAPLYAEKLQYLTTTQLNELYMEMEVLIQELSETLINELALRDELEFEKELKNSFISLLLAVQN 402
            .|:  |.|:::.|:.::|||:..|:|..|:|.||.|:.:||||||||||||:||||||:|:.|||
Human   206 TGS--YEERVKRLSVSELNEILEEIETAIKEYSEELVQQLALRDELEFEKEVKNSFISVLIEVQN 268

  Fly   403 KRRQY-HVEKKRGKFQ---------------------------------------GPEPKYLTTV 427
            |:::: ...||:.|.:                                       |.|.:|||||
Human   269 KQKEHKETAKKKKKLKNGSSQNGKNERSHMPGTRFSMEGISNVIQNGLRHTFGNSGGEKQYLTTV 333

  Fly   428 IPYHLENGTPNNQSLQVLIKILKAINEDSPTVPALLTDYILKVLCPT 474
            |||..:||.|:.:.||:|.|||:|:.|||..||:|||||||||||||
Human   334 IPYEKKNGPPSVEDLQILTKILRAMKEDSEKVPSLLTDYILKVLCPT 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Unc-76	NP_001259172.1	FEZ	143..418	CDD:285060	92/326 (28%)
FEZ2	NP_001036013.1	FEZ	51..270	CDD:285060	88/289 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142918
Domainoid	1	1.000	143	1.000	Domainoid score	I4663
eggNOG	1	0.900	-	-		E1_KOG3919
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3742
Inparanoid	1	1.050	205	1.000	Inparanoid score	I3726
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46356
OrthoDB	1	1.010	-	-		D1186463at2759
OrthoFinder	1	1.000	-	-		FOG0002964
OrthoInspector	1	1.000	-	-		otm40562
orthoMCL	1	0.900	-	-		OOG6_106736
Panther	1	1.100	-	-	LDO	PTHR12394
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1959
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770