DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Unc-76 and Fez2

DIOPT Version :9

Sequence 1:	NP_001259172.1	Gene:	Unc-76 / 31179	FlyBaseID:	FBgn0040395	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001272869.1	Gene:	Fez2 / 225020	MGIID:	2675856	Length:	375	Species:	Mus musculus

Alignment Length:	439	Identity:	135/439 - (30%)
Similarity:	208/439 - (47%)	Gaps:	128/439 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 AGSI--SPNCNTLQGGSLIEIGLSDVGLVPGEGAGVGLDGLEKRSLAVGDHVDNFTETFGGSLED 146
            |||:  ..|||.                .|..|||.              |..      |.|...
Mouse    17 AGSVQEQENCNA----------------SPEAGAGA--------------HAG------GDSFPA 45

  Fly   147 LVNTFDEKITKCFGNYEENVEELAPVQVRSQEEIMNECQMWWTITGNFGNILPIDWSKSYTRQMH 211
            |.::.:||::.||....|.....|.|:..::..::...::|..:|.|:||::|:||..|:||.:|
Mouse    46 LASSLEEKLSLCFRPTSEAEPPRAAVRPITECSLLQGDEIWNALTDNYGNVMPVDWKSSHTRTLH 110

  Fly   212 MPTLNLGQNHTKQQQQNRNQQQQLHNQSHQAYPHTNGLGSGSGSGLDAQTPGDEFNDLTSEDEAV 276
            :.||||.:.                             |...|...||           |::|.:
Mouse   111 LLTLNLSEK-----------------------------GMNDGLLFDA-----------SDEEEL 135

  Fly   277 ANDLDMHALILNGLNGDMDDQPIKTVEEVIKEIDDIMDEAESPLDEPETCDSEVIEKAREVL--- 338
            ...||||::|::.:|    ::|:.|.::||:||:::|.|:..|.|:.....|:.:....:.:
Mouse   136 REQLDMHSIIVSCVN----EEPLFTADQVIEEIEEMMQESPDPEDDETPTQSDRLSMLSQEIQTL 196

  Fly   339 ---GAPLYAEKLQYLTTTQLNELYMEMEVLIQELSETLINELALRDELEFEKELKNSFISLLLAV 400
               ....|.|:::.|:.::||||..|:|..|::.||.|:.:||||||||||||::|||||.|:.|
Mouse   197 KRSSMSSYEERVKRLSVSELNELLEEIEAAIKQYSEELVQQLALRDELEFEKEVENSFISALIEV 261

  Fly   401 QNKRRQY-HVEKKRGKFQ---------------------------------------GPEPKYLT 425
            |||:::: ...||:.|.:                                       |.|.:|||
Mouse   262 QNKQKEHKETAKKKKKLKSGSSQNGRSERSHMPGTRFSMEGISNVIQNGLRHTFGNSGGEKQYLT 326

  Fly   426 TVIPYHLENGTPNNQSLQVLIKILKAINEDSPTVPALLTDYILKVLCPT 474
            |||||..::|.|:.:.||:|.|||.|:.|||..||:|||||||||||||
Mouse   327 TVIPYEKKSGPPSVEDLQILTKILHAMKEDSEKVPSLLTDYILKVLCPT 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Unc-76	NP_001259172.1	FEZ	143..418	CDD:285060	86/320 (27%)
Fez2	NP_001272869.1	FEZ	42..265	CDD:285060	82/266 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833041
Domainoid	1	1.000	143	1.000	Domainoid score	I4635
eggNOG	1	0.900	-	-		E1_KOG3919
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3742
Inparanoid	1	1.050	204	1.000	Inparanoid score	I3735
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46356
OrthoDB	1	1.010	-	-		D1186463at2759
OrthoFinder	1	1.000	-	-		FOG0002964
OrthoInspector	1	1.000	-	-		otm42633
orthoMCL	1	0.900	-	-		OOG6_106736
Panther	1	1.100	-	-	LDO	PTHR12394
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3073
SonicParanoid	1	1.000	-	-		X1959
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800