DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16903 and CCNT2

DIOPT Version :9

Sequence 1:	NP_569980.1	Gene:	CG16903 / 31178	FlyBaseID:	FBgn0040394	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_490595.1	Gene:	CCNT2 / 905	HGNCID:	1600	Length:	730	Species:	Homo sapiens

Alignment Length:	650	Identity:	133/650 - (20%)
Similarity:	211/650 - (32%)	Gaps:	235/650 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 KIDVTPSSQDGLDHETEKDLRILGCELIQTAGILLRLPQVAMATGQVLFQRFFYSKSFVRHNMET 159
            :::.|||.:.|::.:.|...|.....|||..|..|.:.|:.:.|..|...||:...||.:.|...
Human    17 QLENTPSRRCGVEADKELSCRQQAANLIQEMGQRLNVSQLTINTAIVYMHRFYMHHSFTKFNKNI 81

  Fly   160 VAMSCVCLASKIEEAPRRIRDVINVFHHIKQVRAQKEISPMV---LDPYYTNLKMQVIKAERRVL 221
            ::.:.:.||:|:||..|::..||.|.|     .....:.|::   .|.|....:..|| .|..:|
Human    82 ISSTALFLAAKVEEQARKLEHVIKVAH-----ACLHPLEPLLDTKCDAYLQQTQELVI-LETIML 140

  Fly   222 KELGFCVHVKHPHKLIVMYLQVLQYEKHEKLMQLSWNFMNDSLRTDVF-MRYTPEAIACACIYLS 285
            :.|||.:.::|||..:|...|:::..|  .|.|.|:....:||....| ::|.|..|||.||:|:
Human   141 QTLGFEITIEHPHTDVVKCTQLVRASK--DLAQTSYFMATNSLHLTTFCLQYKPTVIACVCIHLA 203

  Fly   286 ARKLNIPLPNSPP---WFGIF--RVPMADITDICYRVMELYMRSKPVVEKLEAAVDELKK----R 341
            .:..|..:|.|..   |:...  .|.:..:.::.:..:::          ||...:.|||    |
Human   204 CKWSNWEIPVSTDGKHWWEYVDPTVTLELLDELTHEFLQI----------LEKTPNRLKKIRNWR 258

  Fly   342 YIDARNKTK----EANTP---------------------------------PAVITVDRNN---- 365
            ...|..|.|    .:.||                                 ||.:.::..|
Human   259 ANQAARKPKVDGQVSETPLLGSSLVQNSILVDSVTGVPTNPSFQKPSTSAFPAPVPLNSGNISVQ 323

  Fly   366 ----------------------GSHNAWGGFIQRAIPLPLPSEKS-------------------- 388
                                  .||..|......|....|.|:|.
Human   324 DSHTSDNLSMLATGMPSTSYGLSSHQEWPQHQDSARTEQLYSQKQETSLSGSQYNINFQQGPSIS 388

  Fly   389 --------PQKDSRSRSRSRTRTH-SRTPRSRSPRSRSPS-----------RERTK--------- 424
                    |.|.|...|..:..|| :.:.:...|.|.:|.           ||:.|
Human   389 LHSGLHHRPDKISDHSSVKQEYTHKAGSSKHHGPISTTPGIIPQKMSLDKYREKRKLETLDLDVR 453

  Fly   425 ---------KTHRSRSSRSRSRS-----------------------------------PPKHKKK 445
                     :.|:...|::.|.|                                   ||..|..
Human   454 DHYIAAQVEQQHKQGQSQAASSSSVTSPIKMKIPIANTEKYMADKKEKSGSLKLRIPIPPTDKSA 518

  Fly   446 S--------------RHYS----RSPTRSNSPH------SKHRKSKSSRER--SEYYSKKDRSGN 484
            |              ||.|    ...::.:|||      .||::..|||..  |..:|......:
Human   519 SKEELKMKIKVSSSERHSSSDEGSGKSKHSSPHISRDHKEKHKEHPSSRHHTSSHKHSHSHSGSS 583

  Fly   485 PGSSNNLGDG--------------DKYRNSVSNSGK--------HSRYSSSSSRRNSGGGGDGRS 527
            .|.|.:..||              |...:|.|:|.|        |:.:|..|....|.|.....|
Human   584 SGGSKHSADGIPPTVLRSPVGLSSDGISSSSSSSRKRLHVNDASHNHHSKMSKSSKSSGSSSSSS 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16903	NP_569980.1	CYCLIN	114..203	CDD:238003	25/91 (27%)
CG16903	NP_569980.1	CYCLIN	235..321	CDD:214641	22/91 (24%)
CCNT2	NP_490595.1	Interaction with MDFIC and MDFI. /evidence=ECO:0000269\|PubMed:17289077	1..300		75/300 (25%)
		CCL1	8..>216	CDD:227640	62/206 (30%)
		CYCLIN	37..108	CDD:238003	23/70 (33%)
		Interaction with POLR2A. /evidence=ECO:0000269\|PubMed:15563843	250..300		9/49 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..430		16/88 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	497..652		31/151 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5333
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1437076at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820