DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16903 and CCNL2

DIOPT Version :9

Sequence 1:	NP_569980.1	Gene:	CG16903 / 31178	FlyBaseID:	FBgn0040394	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	XP_011540518.1	Gene:	CCNL2 / 81669	HGNCID:	20570	Length:	553	Species:	Homo sapiens

Alignment Length:	545	Identity:	225/545 - (41%)
Similarity:	291/545 - (53%)	Gaps:	93/545 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 SSSGAAPGADAAGGDAGGVAAAQADANKPIYPRLFNRIVLTLENSLIPEGKIDVTPSSQDGLDHE 109
            ::..|||.|.|....:||  |........|..||::.:::||||.|:|:.|:..|||...|||.:
Human    10 AAGSAAPAAAAGAPGSGG--APSGSQGVLIGDRLYSGVLITLENCLLPDDKLRFTPSMSSGLDTD 72

  Fly   110 TEKDLRILGCELIQTAGILLRLPQVAMATGQVLFQRFFYSKSFVRHNMETVAM------------ 162
            ||.|||::||||||.||||||||||||||||||||||||:||||:|:||..::
Human    73 TETDLRVVGCELIQAAGILLRLPQVAMATGQVLFQRFFYTKSFVKHSMEPSSLWRPSGRRGWGQT 137

  Fly   163 --SCVCLASKIEE--APRRIRDVINVFHHI---------KQVRAQKEIS--------PMVLDPYY 206
              .|...||....  .|...:|......|.         .....||.:.        |::||..|
Human   138 WACCNASASACVNGLCPPGFQDRRGPKTHTGRHQCVSPPSTAERQKTLCSLSGRKPVPLLLDQDY 202

  Fly   207 TNLKMQVIKAERRVLKELGFCVHVKHPHKLIVMYLQVLQYEKHEKLMQLSWNFMNDSLRTDVFMR 271
            .|||.|:||||||||||||||||||||||:||||||||:.|:::.|:|.|||:||||||||||:|
Human   203 VNLKNQIIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECERNQHLVQTSWNYMNDSLRTDVFVR 267

  Fly   272 YTPEAIACACIYLSARKLNIPLPNSPPWFGIFRVPMADITDICYRVMELYMRSKPVVEKLEAAVD 336
            :.||:||||||||:||.|.|||||.|.||.:|.....:|.:||.::::||.|.|..:..||..|
Human   268 FQPESIACACIYLAARTLEIPLPNRPHWFLLFGATEEEIQEICLKILQLYARKKVDLTHLEGEV- 331

  Fly   337 ELKKRYIDARNKTKEANTPPAVITVDRNNGSHNA-------WGGFIQRAIPLPLPSEK------- 387
            |.:|..|:..........|.....:|..:|...|       ..|...:..||.:.:.|
Human   332 EKRKHAIEEAKAQARGLLPGGTQVLDGTSGFSPAPKLVESPKEGKGSKPSPLSVKNTKRRLEGAK 396

  Fly   388 -----SP------QKDSRSRSRSRTRTHSRTP-RSRSPRSRSPSRERTKKTHRSRS-SRSRSRSP 439
                 ||      .::||||||||.:::||:| ||.||:.|......|....:|:| |||||.||
Human   397 KAKADSPVNGLPKGRESRSRSRSREQSYSRSPSRSASPKRRKSDSGSTSGGSKSQSRSRSRSDSP 461

  Fly   440 PKHKKKSRHYSRSPTRSN----------SPHSKHRKSKSSRERSEYYSKKDRSGNPGSSNNLGDG 494
            |:...:|..|..|..|.:          .|| |.|...|||.||.   .::|:.|||
Human   462 PRQAPRSAPYKGSEIRGSRKSKDCKYPQKPH-KSRSRSSSRSRSR---SRERADNPG-------- 514

  Fly   495 DKYRNSVSNSGKHSRYSSSSSRRNS 519
             ||:       |.|.|.....|..|
Human   515 -KYK-------KKSHYYRDQRRERS 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16903	NP_569980.1	CYCLIN	114..203	CDD:238003	48/121 (40%)
CG16903	NP_569980.1	CYCLIN	235..321	CDD:214641	51/85 (60%)
CCNL2	XP_011540518.1	CCL1	69..>306	CDD:227640	129/236 (55%)
CCNL2	XP_011540518.1	CYCLIN	233..315	CDD:214641	50/81 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	185	1.000	Domainoid score	I3386
eggNOG	1	0.900	-	-		E1_COG5333
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1866
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002258
OrthoInspector	1	1.000	-	-		otm41062
orthoMCL	1	0.900	-	-		OOG6_102010
Panther	1	1.100	-	-	O	PTHR10026
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1832
SonicParanoid	1	1.000	-	-		X1491
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.850