DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16903 and Ccnt2

DIOPT Version :9

Sequence 1:	NP_569980.1	Gene:	CG16903 / 31178	FlyBaseID:	FBgn0040394	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_082675.1	Gene:	Ccnt2 / 72949	MGIID:	1920199	Length:	723	Species:	Mus musculus

Alignment Length:	638	Identity:	132/638 - (20%)
Similarity:	216/638 - (33%)	Gaps:	213/638 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 KIDVTPSSQDGLDHETEKDLRILGCELIQTAGILLRLPQVAMATGQVLFQRFFYSKSFVRHNMET 159
            :::.|||.:.|::.:.|...|.....|||..|..|.:.|:.:.|..|...||:...||.:.|...
Mouse    17 QLENTPSRRCGVEADEELSHRQQAANLIQDMGQRLNVSQLTINTAIVYMHRFYMHHSFTKFNRNI 81

  Fly   160 VAMSCVCLASKIEEAPRRIRDVINVFHHIKQVRAQKEISPM--VLD---PYYTNLKMQVIKAERR 219
            ::.:.:.||:|:||..|::..||.|.|..        :.|:  :||   ..|.....:::..|..
Mouse    82 ISPTALFLAAKVEEQARKLEHVIKVAHAC--------LHPLEPLLDTKCDAYLQQTQELVLLETI 138

  Fly   220 VLKELGFCVHVKHPHKLIVMYLQVLQYEKHEKLMQLSWNFMNDSLRTDVF-MRYTPEAIACACIY 283
            :|:.|||.:.::|||..:|...|:::..|  .|.|.|:....:||....| ::|.|..|||.||:
Mouse   139 MLQTLGFEITIEHPHTDVVKCTQLVRASK--DLAQTSYFMATNSLHLTTFCLQYKPTVIACVCIH 201

  Fly   284 LSARKLNIPLPNSPP---WFGIF--RVPMADITDICYRVMELYMRSKPVVEKLEAAVDELKKRYI 343
            |:.:..|..:|.|..   |:...  .|.:..:.::.:..:::          ||.....||:
Mouse   202 LACKWSNWEIPVSTDGKHWWEYVDPTVTLELLDELTHEFLQI----------LEKTPSRLKR--- 253

  Fly   344 DARNKTKEANTPPAVITVDRNNGSHNAWG-GFIQRAI------------------------PLPL 383
             .||....|..|    .||.........| ..:|.:|                        |:||
Mouse   254 -IRNWRAMAKKP----KVDGQVSETPLLGSSLVQNSILVDSVTGVPANPSFQKPSTSTFPAPIPL 313

  Fly   384 PSEKSPQKDSR-------------SRSRSRTRTHSRTPRSRSPRSRSP----------------- 418
            .|..:..:|||             |.|.|.: :|...|:........|
Mouse   314 NSGSTSVQDSRASDNLSVLAAGMPSTSYSLS-SHQEWPQHPDSARTDPVYTQKQEATLSGSQYIS 377

  Fly   419 -----------------------SRERTKKTHRSRSSRSRSRSP------------PKHKKKSR- 447
                                   |..:.:.||::.||:.....|            .|:::|.:
Mouse   378 FQQGPSMALHSGLHHRPDKVADHSSAKQEYTHKAGSSKHHGPIPATPGMLPQKMSLDKYREKRKL 442

  Fly   448 ---------HYSRSPTRSNSPHS----------------KHRKSKSSRERSEYYSKKDRSG---- 483
                     ||..:.......|.                |...:.|.|.......||:|||
Mouse   443 ETLDVDTRDHYLAAHAEQQHKHGPAQAVTGTSVTSPIKMKLPLTNSDRPEKHVAEKKERSGSLKL 507

  Fly   484 -------NPGSSN-------NLGDGDKYRNSVSNSGKHSRYSSSSSRR----------------- 517
                   :.|.|.       .:...:::.:|...||| |::||....|
Mouse   508 RIPIPPPDKGPSKEELKMKIKVASSERHSSSDEGSGK-SKHSSPHISRDHKEKHKEHPANRHHSS 571

  Fly   518 ------NSGGG---GDG------RSGGGGGGGGGGNGN------HGSRGGHKH 549
                  :|||.   .||      ||..|.|..|..:.:      |.|...|.|
Mouse   572 HKYLHMHSGGSKHTADGMPPTVLRSPVGLGPEGVSSASSARKKLHSSEASHNH 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16903	NP_569980.1	CYCLIN	114..203	CDD:238003	25/90 (28%)
CG16903	NP_569980.1	CYCLIN	235..321	CDD:214641	22/91 (24%)
Ccnt2	NP_082675.1	Interaction with MDFIC and MDFI. /evidence=ECO:0000250\|UniProtKB:O60583	1..298		76/308 (25%)
		CCL1	8..>216	CDD:227640	61/208 (29%)
		CYCLIN	36..108	CDD:238003	23/71 (32%)
		Interaction with POLR2A. /evidence=ECO:0000250\|UniProtKB:O60583	250..298		11/55 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..325		6/27 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..364		5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..428		6/42 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	458..645		33/168 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5333
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810