DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16903 and Ccnl2

DIOPT Version :9

Sequence 1:	NP_569980.1	Gene:	CG16903 / 31178	FlyBaseID:	FBgn0040394	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	XP_036020147.1	Gene:	Ccnl2 / 56036	MGIID:	1927119	Length:	519	Species:	Mus musculus

Alignment Length:	564	Identity:	250/564 - (44%)
Similarity:	322/564 - (57%)	Gaps:	111/564 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 NNSSSGAAPGADAAGGDAGGVAAAQADANKPIYPRLFNRIVLTLENSLIPEGKIDVTPSSQDGLD 107
            ::.|:|||||:.       ||.         |..||::.:::||||.|:|:.|:..|||...|||
Mouse    20 SSGSAGAAPGSQ-------GVL---------IGDRLYSGVLITLENCLLPDDKLRFTPSMSSGLD 68

  Fly   108 HETEKDLRILGCELIQTAGILLRLPQVAMATGQVLFQRFFYSKSFVRHNMETVAMSCVCLASKIE 172
            .:||..||::||||||.||||||||||||||||||||||||:||||:|:||.|:|:||.||||||
Mouse    69 VDTETGLRVVGCELIQAAGILLRLPQVAMATGQVLFQRFFYTKSFVKHSMEHVSMACVHLASKIE 133

  Fly   173 EAPRRIRDVINVFHHIKQVRAQKEISPMVLDPYYTNLKMQVIKAERRVLKELGFCVHVKHPHKLI 237
            ||||||||||||||.::.:|.:|:..|:|||..|.|||.|:||||||||||||||||||||||:|
Mouse   134 EAPRRIRDVINVFHRLRHLREKKKPVPLVLDQEYVNLKNQIIKAERRVLKELGFCVHVKHPHKII 198

  Fly   238 VMYLQVLQYEKHEKLMQLSWNFMNDSLRTDVFMRYTPEAIACACIYLSARKLNIPLPNSPPWFGI 302
            |||||||:.|:::.|:|.:||:||||||||||:|:.||:||||||||:||.|.|||||.|.||.:
Mouse   199 VMYLQVLECERNQHLVQTAWNYMNDSLRTDVFVRFQPESIACACIYLAARTLEIPLPNRPHWFLL 263

  Fly   303 FRVPMADITDICYRVMELYMRSKPVVEKLEAAVDELKKRYIDARNKTK------------EANTP 355
            |.....:|.:||:::::||.|.|..:..||:.|::.|....:|:.:.|            .|...
Mouse   264 FGATEEEIQEICFKILQLYTRKKVDLTHLESEVEKRKHAIEEAKARAKGLLPGTAPGLDSAAGFS 328

  Fly   356 PAVITVDRNNGSHNAWGGFIQRAIPLPLPSEKS-------PQK--------------DSRSRSRS 399
            ||...|:   ......||     .|.| ||.||       |:|              :|||:|||
Mouse   329 PAPKLVE---SPKEGKGG-----KPSP-PSGKSAKRKMEGPKKAQGHSPVNGLLKGQESRSQSRS 384

  Fly   400 RTRTHSRTP-RSRSPRSRSPSRERTKKTHRSRS-SRSRSRSPPKHKKKSRHYSRSPTR------- 455
            |.:::||:| ||.||:.|......|....:|:| |||||.|||:...:...|..|..|
Mouse   385 REQSYSRSPSRSASPKRRKSDSGSTSGGSKSQSRSRSRSDSPPRQVHRGAPYKGSEVRGSRKSKD 449

  Fly   456 ----SNSPHSKHRKSKSSRERSEYYSKKDRSGNPGSSNNLGDGDKYRNSVSNSGKHSRYSSSSSR 516
                :..|| |.|...|||.||....:.|.||            ||:       |.|.|.....|
Mouse   450 CKYLTQKPH-KSRSRSSSRSRSRSRERTDNSG------------KYK-------KKSHYYRDQRR 494

  Fly   517 RNSGGGGDGRSGGGGGGGGGGNGNHGSRGGHKHRDGDRSRDRKR 560
            ..|      ||              ..|.||::........|.|
Mouse   495 ERS------RS--------------YERTGHRYERDHPGHSRHR 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16903	NP_569980.1	CYCLIN	114..203	CDD:238003	67/88 (76%)
CG16903	NP_569980.1	CYCLIN	235..321	CDD:214641	50/85 (59%)
Ccnl2	XP_036020147.1	CYCLIN_CCNL2_rpt1	33..188	CDD:410293	105/163 (64%)
Ccnl2	XP_036020147.1	CYCLIN_CCNL2_rpt2	193..315	CDD:410296	63/121 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	185	1.000	Domainoid score	I3371
eggNOG	1	0.900	-	-		E1_COG5333
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	415	1.000	Inparanoid score	I1812
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002258
OrthoInspector	1	1.000	-	-		otm43133
orthoMCL	1	0.900	-	-		OOG6_102010
Panther	1	1.100	-	-	O	PTHR10026
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1832
SonicParanoid	1	1.000	-	-		X1491
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.850