Protein Alignment CG4045 and METTL1

DIOPT Version :10

• Sequence 1: NP_569978.1
• Gene: CG4045 / 31176
• FlyBaseID: FBgn0025629
• Length: 256
• Species: Drosophila melanogaster
• Sequence 2: NP_005362.3
• Gene: METTL1 / 4234
• HGNCID: 7030
• Length: 276
• Species: Homo sapiens
• Alignment Length: 255
• Identity: 151/255 - (59%)
• Similarity: 183/255 - (71%)
• Gaps: 21/255 - (8%)

  Fly    21 NPTSAVTGLPQKRYYRQRAHSNPIADHSFDYPARPEDVDWRSMYP----GIQQGQ---------- 71
            |...|....||||||||||||||:|||:..||.:||::||..:||    .:.|.|
Human     7 NVAGAEAPPPQKRYYRQRAHSNPMADHTLRYPVKPEEMDWSELYPEFFAPLTQNQSHDDPKDKKE 71

  Fly    72 -----QVSFADIGCGYGGFLVTLGEMFPEKLSIGMEIRVKVSDYVVDRIAALRRRCADTGAYQNI 131
                 ||.||||||||||.||.|..:||:.|.:|:||||||||||.|||.||  |.|..|.:|||
Human    72 KRAQAQVEFADIGCGYGGLLVELSPLFPDTLILGLEIRVKVSDYVQDRIRAL--RAAPAGGFQNI 134

  Fly   132 ACLRTNAMKYLPNYFVKGQLEKMFFLYPDPHFKRAKHKWRIINQALLSEYAYILRKGGLLYTMTD 196
            ||||:||||:|||:|.||||.|||||:|||||||.|||||||:..||:||||:||.|||:||:||
Human   135 ACLRSNAMKHLPNFFYKGQLTKMFFLFPDPHFKRTKHKWRIISPTLLAEYAYVLRVGGLVYTITD 199

  Fly   197 VEDLHKWIVTHMEEHPLYERLTEEEANADPITPKLYQSSEEGAKVVRNKGDHFLAIFRRL 256
            |.:||.|:.||.|||||:||:..|:.:.||:...|..|:|||.||:||.|.:|.|||||:
Human   200 VLELHDWMCTHFEEHPLFERVPLEDLSEDPVVGHLGTSTEEGKKVLRNGGKNFPAIFRRI 259

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4045	NP_569978.1	Methyltransf_4	71..251	CDD:367068	118/194 (61%)
METTL1	NP_005362.3	Disordered. /evidence=ECO:0000305|PubMed:36599985	1..36		19/28 (68%)
		Methyltransf_4	77..254	CDD:367068	117/178 (66%)
		AlphaC helix. /evidence=ECO:0000269|PubMed:36599985	164..172		6/7 (86%)
		Alpha6 helix. /evidence=ECO:0000269|PubMed:36599985	238..246		5/7 (71%)