DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4045 and trm8

DIOPT Version :9

Sequence 1:	NP_569978.1	Gene:	CG4045 / 31176	FlyBaseID:	FBgn0025629	Length:	256	Species:	Drosophila melanogaster
Sequence 2:	NP_588028.1	Gene:	trm8 / 2539574	PomBaseID:	SPCPB16A4.04c	Length:	273	Species:	Schizosaccharomyces pombe

Alignment Length:	270	Identity:	129/270 - (47%)
Similarity:	170/270 - (62%)	Gaps:	15/270 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVATGGQAQDQGQNQEPDV------LNPTSAVTG-LPQKRYYRQRAHSNPIADHSFDYPARPEDV 58
            |.||..::..|.|.:|.:.      |:....|.| ||.||.:|||||:|.::||..:||..|.::
pombe     1 MSATAKKSAAQLQREEEEARKKLKRLSKQGGVEGRLPMKRLFRQRAHANVLSDHELEYPRSPSEM 65

  Fly    59 DWRSMYP--GIQQGQQVSFADIGCGYGGFLVTLGEMFPEKLSIGMEIRVKVSDYVVDRIAALRRR 121
            ||...||  .::..::|...||||||||..|.||..||:.|.:|||||::||||:.::|.|||.|
pombe    66 DWSPYYPDFDVESNKKVEIVDIGCGYGGLTVALGPQFPDTLVLGMEIRMQVSDYLKEKIQALRYR 130

  Fly   122 CAD-----TGAYQNIACLRTNAMKYLPNYFVKGQLEKMFFLYPDPHFKRAKHKWRIINQALLSEY 181
             ||     .|.|:||:.||.|..|:|||:|.||||.||||.:||||||..|||.|||...|.|||
pombe   131 -ADHEEPVPGGYKNISVLRMNCQKFLPNFFEKGQLSKMFFCFPDPHFKARKHKNRIITSTLASEY 194

  Fly   182 AYILRKGGLLYTMTDVEDLHKWIVTHMEEHPLYERLTEEEANADPITPKLYQSSEEGAKVVRNKG 246
            ||.:|..|.|||:||||:||.|:..|::.|||:.|.|:||...|.....:...:|||.||.||.|
pombe   195 AYFIRPHGTLYTITDVEELHVWMAQHLDAHPLFRRFTKEEEENDICVTLMTNETEEGKKVARNGG 259

  Fly   247 DHFLAIFRRL 256
            ..|:|.:.|:
pombe   260 KKFVACYERI 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4045	NP_569978.1	Methyltransf_4	71..251	CDD:280538	99/184 (54%)
trm8	NP_588028.1	TrmB	31..272	CDD:223298	122/240 (51%)
trm8	NP_588028.1	Methyltransf_4	80..264	CDD:280538	99/184 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	200	1.000	Domainoid score	I663
eggNOG	1	0.900	-	-		E1_COG0220
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3918
Inparanoid	1	1.050	251	1.000	Inparanoid score	I782
OMA	1	1.010	-	-		QHG53626
OrthoFinder	1	1.000	-	-		FOG0002765
OrthoInspector	1	1.000	-	-		oto101179
orthoMCL	1	0.900	-	-		OOG6_100919
Panther	1	1.100	-	-	LDO	PTHR23417
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1553
SonicParanoid	1	1.000	-	-		X2148
TreeFam	1	0.960	-	-
	14	13.860