DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4045 and metl-1

DIOPT Version :9

Sequence 1:	NP_569978.1	Gene:	CG4045 / 31176	FlyBaseID:	FBgn0025629	Length:	256	Species:	Drosophila melanogaster
Sequence 2:	NP_496448.1	Gene:	metl-1 / 174753	WormBaseID:	WBGene00012205	Length:	256	Species:	Caenorhabditis elegans

Alignment Length:	236	Identity:	149/236 - (63%)
Similarity:	182/236 - (77%)	Gaps:	1/236 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PT-SAVTGLPQKRYYRQRAHSNPIADHSFDYPARPEDVDWRSMYPGIQQGQQVSFADIGCGYGGF 85
            || ..|.|||||::|||||||||.:||..:||..|..:||...|....:|:||.||||||||||.
Worm    16 PTCETVPGLPQKKHYRQRAHSNPHSDHDIEYPLTPNHMDWTKYYGDYTKGRQVDFADIGCGYGGL 80

  Fly    86 LVTLGEMFPEKLSIGMEIRVKVSDYVVDRIAALRRRCADTGAYQNIACLRTNAMKYLPNYFVKGQ 150
            |:.|...:|:.|.|||||||||||||.::|.|||:..|:.|.|:|:|.||:|||||:||||.|||
Worm    81 LMRLSPKYPDNLMIGMEIRVKVSDYVNEKIQALRKHHAEAGHYRNVAVLRSNAMKYMPNYFHKGQ 145

  Fly   151 LEKMFFLYPDPHFKRAKHKWRIINQALLSEYAYILRKGGLLYTMTDVEDLHKWIVTHMEEHPLYE 215
            |.|||||:||||||..|||||||...|||||||:||:||::||:|||:|||:|:|.|:.||||:|
Worm   146 LSKMFFLFPDPHFKNKKHKWRIITPTLLSEYAYVLREGGIIYTITDVKDLHEWMVKHLSEHPLFE 210

  Fly   216 RLTEEEANADPITPKLYQSSEEGAKVVRNKGDHFLAIFRRL 256
            ||||||...|||...|::|:|||.||.||.|..:.||||||
Worm   211 RLTEEEMKKDPIVEMLFESTEEGQKVTRNDGGKWPAIFRRL 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4045	NP_569978.1	Methyltransf_4	71..251	CDD:280538	117/179 (65%)
metl-1	NP_496448.1	TrmB	30..253	CDD:223298	141/222 (64%)
metl-1	NP_496448.1	Methyltransf_4	66..246	CDD:280538	117/179 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166266
Domainoid	1	1.000	257	1.000	Domainoid score	I1087
eggNOG	1	0.900	-	-		E1_COG0220
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3918
Inparanoid	1	1.050	321	1.000	Inparanoid score	I1493
Isobase	1	0.950	-	0	Normalized mean entropy	S384
OMA	1	1.010	-	-		QHG53626
OrthoDB	1	1.010	-	-		D1417652at2759
OrthoFinder	1	1.000	-	-		FOG0002765
OrthoInspector	1	1.000	-	-		oto18826
orthoMCL	1	0.900	-	-		OOG6_100919
Panther	1	1.100	-	-	LDO	PTHR23417
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1553
SonicParanoid	1	1.000	-	-		X2148
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750