DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rtca and rtca

DIOPT Version :9

Sequence 1:	NP_001284801.1	Gene:	Rtca / 31175	FlyBaseID:	FBgn0025630	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_955830.1	Gene:	rtca / 321129	ZFINID:	ZDB-GENE-030131-9687	Length:	363	Species:	Danio rerio

Alignment Length:	360	Identity:	147/360 - (40%)
Similarity:	214/360 - (59%)	Gaps:	5/360 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AEKMLEIDGSYLEGGGQALRNALSLSCILGKPVRVVKIRASRPSPGLSHQHLHGLNLLRDITNAD 67
            |....|:|||.:|||||.||.:.:||||.|..:::.||||.|.:|||..|||.||.||||:.|.:
Zfish     2 AATTFEMDGSVMEGGGQILRVSAALSCIQGASIKINKIRAGRSTPGLRPQHLSGLELLRDMCNGN 66

  Fly    68 VVGNYLLSSTVEFTPRTILDNTYRVETHTAASITLIYQMALPVLLFAGRPSRLIVSGGTNVDFAP 132
            :.|..:.||.:..||..|....:..:||||.|:||:.|::||..|||..||.|.:.||||.:.||
Zfish    67 LEGATVGSSEITLTPGKIKGGNHIADTHTAGSVTLLMQVSLPCALFAQGPSELCLKGGTNAEMAP 131

  Fly   133 PVEYMQEVLLPNLKHFGVSFDLKVQRYGFYPRGQGRCQLDVQPVTKLNSGKLVAFGRIKSVSGVA 197
            .::|..:|..|.::.|||.||..::..|:||:|.|...|.|.|..:|:...:...|.|..:.|.|
Zfish   132 QIDYTVKVFKPIVERFGVQFDCDLRMRGYYPKGGGEVVLKVNPAKELSPINMTERGNITKIYGRA 196

  Fly   198 YCAGRLPVNIAIDMQQTAQREIHRLWPSQQCSIEPIKHSRQKAFHNGAGILMTVNTTSDVVLGAS 262
            :.||.||..:|.||...|.|.|.:.......:|:.:: .:.||..||.||::...:::..:...|
Zfish   197 FVAGVLPFKLAKDMSTAAIRTIRKEIKDLYINIQSLQ-EKDKACGNGNGIIIIAESSTGCIFAGS 260

  Fly   263 ALGKKRIDGHVLGSEASCQLGDYMRKQVCVDDYMQDQLIIYMALAVGRSTMRTGKLTNHTRTAIN 327
            :||||.:....:|.||:..|...:|...|||:::||||||:||||.|.|.||||.:|.||:|||:
Zfish   261 SLGKKGVYADKVGIEAAEMLLRNIRHNGCVDEFLQDQLIIFMALANGTSRMRTGPITLHTQTAIH 325

  Fly   328 VAEQMTGVKFDVAM----EPGGQMLVSCKGLGHVN 358
            ||||:|..||.::.    ......::.|:|:|..|
Zfish   326 VAEQLTNAKFAISKAEDENANDTYIIECQGVGATN 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rtca	NP_001284801.1	RNA_3prim_cycl	7..338	CDD:274563	141/330 (43%)
Rtca	NP_001284801.1	RNA_Cyclase_Class_II	9..341	CDD:238446	141/331 (43%)
rtca	NP_955830.1	RNA_Cyclase_Class_II	8..339	CDD:238446	141/331 (43%)
rtca	NP_955830.1	RTC	12..337	CDD:279479	138/325 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574246
Domainoid	1	1.000	255	1.000	Domainoid score	I2013
eggNOG	1	0.900	-	-		E1_COG0430
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2766
Inparanoid	1	1.050	268	1.000	Inparanoid score	I3006
OMA	1	1.010	-	-		QHG60643
OrthoDB	1	1.010	-	-		D1151685at2759
OrthoFinder	1	1.000	-	-		FOG0007129
OrthoInspector	1	1.000	-	-		oto39498
orthoMCL	1	0.900	-	-		OOG6_103060
Panther	1	1.100	-	-	LDO	PTHR11096
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11072
SonicParanoid	1	1.000	-	-		X5996
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800