DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4199 and hcaD

DIOPT Version :9

Sequence 1:	NP_001188537.1	Gene:	CG4199 / 31174	FlyBaseID:	FBgn0025628	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_417037.1	Gene:	hcaD / 945427	ECOCYCID:	G7336	Length:	400	Species:	Escherichia coli

Alignment Length:	400	Identity:	108/400 - (27%)
Similarity:	187/400 - (46%)	Gaps:	32/400 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 QRVFIVVGGGPSGAVAVETIRQEGFTGRLIFVCREDYLPYDRVKISKAMNLE----IEQLRFRDE 239
            ::..|:||||.:.|:|..::||:||||.|.....|.:|||:|..:||:|.||    ::|:  ...
E. coli     3 EKTIIIVGGGQAAAMAAASLRQQGFTGELHLFSDERHLPYERPPLSKSMLLEDSPQLQQV--LPA 65

  Fly   240 EFYKEYDIELWQGVAAEKLDTAQKELHCSNGYVVKYDKIYLATGCSAFRPPIPGVNLENVRTVRE 304
            .:::|.::.|..||..:.|....:||..:||....:|::::|||.:|...|:.....|...|:|.
E. coli    66 NWWQENNVHLHSGVTIKTLGRDTRELVLTNGESWHWDQLFIATGAAARPLPLLDALGERCFTLRH 130

  Fly   305 LADTKAILASITPESRVVCLGSSFIALEAAAGLVSKVQSVTVV-------GRENVPLKAAFGAEI 362
            ..|...:...:.||..||.:|:..|.||.||....:...|||:       ||...|       .:
E. coli   131 AGDAARLREVLQPERSVVIIGAGTIGLELAASATQRRCKVTVIELAATVMGRNAPP-------PV 188

  Fly   363 GQRVLQLFEDNKVVMRMESGIAEIVGNEDGKVSEVVLVDDTRLPCDLLILGTGSKLNTQFLAKSG 427
            .:.:||..:...|.:.:.:.|..:|   ||:..|:.|.....|..|::|.|.|...|.| ||:..
E. coli   189 QRYLLQRHQQAGVRILLNNAIEHVV---DGEKVELTLQSGETLQADVVIYGIGISANEQ-LAREA 249

  Fly   428 VKVNRNGSVDVTDFLESNVPDVYVGGDIANAHI-HGLAHDRVNIGHYQLAQYHGRVAAINMCGGV 491
            .....||.| :.:...:..|.::.|||:|...: :|..|   ....::.|....::||..|.|..
E. coli   250 NLDTANGIV-IDEACRTCDPAIFAGGDVAITRLDNGALH---RCESWENANNQAQIAAAAMLGLP 310

  Fly   492 KKLEAVPFFFTLIFGKGIRYAGHGSYKDVIIDGSMEDFKFVAYFINEADTVTAVA-SCGRDPIVA 555
            ..|...|:|::..:...:::.|.....|.:..|:.|..|.:.:.:.....:.||. :.||:  :.
E. coli   311 LPLLPPPWFWSDQYSDNLQFIGDMRGDDWLCRGNPETQKAIWFNLQNGVLIGAVTLNQGRE--IR 373

  Fly   556 QFAELISQGK 565
            ...:.|..||
E. coli   374 PIRKWIQSGK 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4199	NP_001188537.1	Rieske_AIFL_N	59..154	CDD:239560
		Pyr_redox_2	183..465	CDD:285266	87/293 (30%)
		Pyr_redox	320..402	CDD:278498	23/88 (26%)
		Reductase_C	505..577	CDD:291425	11/61 (18%)
hcaD	NP_417037.1	PRK09754	1..396	CDD:170080	107/399 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	113	1.000	Domainoid score	I297
eggNOG	1	0.900	-	-		E1_COG0446
Hieranoid	1	1.000	-	-
Inparanoid	1	1.050	125	1.000	Inparanoid score	I261
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001279
OrthoInspector	1	1.000	-	-		otm51350
orthoMCL	1	0.900	-	-		OOG6_100481
Panther	1	1.100	-	-	LDO	PTHR43557
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
	9	8.860