DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG4199 and AIFM1

DIOPT Version :9

Sequence 1:NP_001188537.1 Gene:CG4199 / 31174 FlyBaseID:FBgn0025628 Length:593 Species:Drosophila melanogaster
Sequence 2:NP_004199.1 Gene:AIFM1 / 9131 HGNCID:8768 Length:613 Species:Homo sapiens


Alignment Length:470 Identity:100/470 - (21%)
Similarity:179/470 - (38%) Gaps:117/470 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   182 FIVVGGGPSGAVAVETIRQEGFTGRLIFVCREDYLPYDRVKISKAM----------NLEIEQ--- 233
            |:::|||.:...|..:||......|::.|..:..|||.|..:||.:          .|..:|   
Human   134 FLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVTKTLRFKQWNG 198

  Fly   234 ----LRFRDEEFY---------KEYDIELWQGVAAEKLDTAQKELHCSNGYVVKYDKIYLATG-- 283
                :.|:...||         :...:.:..|....:||.....:..::|..:.|:|..:|||  
Human   199 KERSIYFQPPSFYVSAQDLPHIENGGVAVLTGKKVVQLDVRDNMVKLNDGSQITYEKCLIATGGT 263

  Fly   284 ---CSAFRPPIPGVNLENVRTV-RELADTKAILASITPESR-VVCLGSSFIALEAAAGLVSKVQS 343
               .||.  ...|..:::..|: |::.|.:: |..|:.|.: :..:|..|:..|.|..|..|.::
Human   264 PRSLSAI--DRAGAEVKSRTTLFRKIGDFRS-LEKISREVKSITIIGGGFLGSELACALGRKARA 325

  Fly   344 VTVVGRENVPLKAAFGAEIGQRVLQLFED-----------------NKV----VMRMESGIAEIV 387
                              :|..|:|||.:                 .||    |..|.:.|.:.|
Human   326 ------------------LGTEVIQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSV 372

  Fly   388 GNEDGKVSEVVLVDDTRLPCDLLILGTGSKLNTQFLAKSGVKVNRN-GSVDVTDFLESNVPDVYV 451
            |...||:. :.|.|..::..|.::...|.:.|.:.....|::::.: |...|...|::. .:::|
Human   373 GVSSGKLL-IKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVNAELQAR-SNIWV 435

  Fly   452 GGDIANAHIHGLAHDRVNIGHYQLAQYHGRVAAINMCGGVKKLEAVPFFFTLIF----GKGIRYA 512
            .||.|..:...|...||.  |:..|...||:|..||.|..|     |::...:|    |..:.|.
Human   436 AGDAACFYDIKLGRRRVE--HHDHAVVSGRLAGENMTGAAK-----PYWHQSMFWSDLGPDVGYE 493

  Fly   513 GHGSYKDVIIDGSMEDFKFVAYFI--------------------NEADTVTAVASCGRDPIVAQF 557
            ..|     ::|.|:..   |..|.                    :|::|.:..:.....|.....
Human   494 AIG-----LVDSSLPT---VGVFAKATAQDNPKSATEQSGTGIRSESETESEASEITIPPSTPAV 550

  Fly   558 AELISQGKCLGRGQI 572
            .:...||:..|:|.|
Human   551 PQAPVQGEDYGKGVI 565

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4199NP_001188537.1 Rieske_AIFL_N 59..154 CDD:239560
Pyr_redox_2 183..465 CDD:285266 71/336 (21%)
Pyr_redox 320..402 CDD:278498 21/103 (20%)
Reductase_C 505..577 CDD:291425 16/92 (17%)
AIFM1NP_004199.1 Mitochondrial localization signal. /evidence=ECO:0000250|UniProtKB:Q9Z0X1 1..31
AIF-MLS 52..>133 CDD:317386
Mitochondrial localization signal. /evidence=ECO:0000250|UniProtKB:Q9Z0X1 63..89
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 100..127
FAD-dependent oxidoreductase. /evidence=ECO:0000250 134..483 84/378 (22%)
Pyr_redox_2 150..462 CDD:311792 71/336 (21%)
Nuclear localization signal. /evidence=ECO:0000255 446..451 1/4 (25%)
AIF_C 465..593 CDD:317164 22/114 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 513..554 3/40 (8%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0446
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.