DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4199 and AIFM2

DIOPT Version :9

Sequence 1:	NP_001188537.1	Gene:	CG4199 / 31174	FlyBaseID:	FBgn0025628	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001185625.1	Gene:	AIFM2 / 84883	HGNCID:	21411	Length:	373	Species:	Homo sapiens

Alignment Length:	363	Identity:	77/363 - (21%)
Similarity:	141/363 - (38%)	Gaps:	81/363 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 IVVGGGPSGAVAVETIRQEGFTGRLIFVCREDYLPYDRVKISKAMNLEIEQLR------FRDEEF 241
            ::||||..|..|...::...             :|:..|.:..:.:..:..||      |..:.|
Human    15 VIVGGGFGGIAAASQLQALN-------------VPFMLVDMKDSFHHNVAALRASVETGFAKKTF 66

  Fly   242 YKEYDI----ELWQGVAAEKLDTAQKELHCSNGYVVKYDKIYLATGCSAFRPPIPGVNLENVRTV 302
            . .|.:    ...||:.. .:|...:.:....|..:.:..:.||||.:.   |.||       ..
Human    67 I-SYSVTFKDNFRQGLVV-GIDLKNQMVLLQGGEALPFSHLILATGSTG---PFPG-------KF 119

  Fly   303 RELADTKAILASITPESR-------VVCLGSSFIALEAAAGL--------VSKVQS-VTVVGREN 351
            .|::..:|.:.:.....|       :|.:|.....:|.||.:        |:.:.| |.:..:|.
Human   120 NEVSSQQAAIQAYEDMVRQVQRSRFIVVVGGGSAGVEMAAEIKTEYPEKEVTLIHSQVALADKEL 184

  Fly   352 VPLKAAFGAEIGQRVLQLFEDNKVVMRME---SGIAEIVGNEDGKVSEVVLVDDTRLPCDLLILG 413
            :|       .:.|.|.::.....|.:.:.   |.:.|:..||..:..:|.....|.:..:|:||.
Human   185 LP-------SVRQEVKEILLRKGVQLLLSERVSNLEELPLNEYREYIKVQTDKGTEVATNLVILC 242

  Fly   414 TGSKLNTQFLAKS-GVKVNRNGSVDVTDFLE----SNVPDVYVGGDIANAHIHGLAHDRVNIGHY 473
            ||.|:|:....|: ..::..:|::.|.:.|:    ||   ||..||.|:.....:|:
Human   243 TGIKINSSAYRKAFESRLASSGALRVNEHLQVEGHSN---VYAIGDCADVRTPKMAY-------- 296

  Fly   474 QLAQYHGRVAAINMCGGVKK--LEAV-PFFFTLIFGKG 508
             ||..|..:|..|:...||:  |:|. |...|.:...|
Human   297 -LAGLHANIAVANIVNSVKQRPLQAYKPGALTFLLSMG 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4199	NP_001188537.1	Rieske_AIFL_N	59..154	CDD:239560
		Pyr_redox_2	183..465	CDD:285266	64/315 (20%)
		Pyr_redox	320..402	CDD:278498	19/100 (19%)
		Reductase_C	505..577	CDD:291425	1/4 (25%)
AIFM2	NP_001185625.1	NirB	39..356	CDD:330997	70/326 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0446
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810