DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4199 and aifm4

DIOPT Version :9

Sequence 1:	NP_001188537.1	Gene:	CG4199 / 31174	FlyBaseID:	FBgn0025628	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	XP_005157647.1	Gene:	aifm4 / 791218	ZFINID:	ZDB-GENE-070112-2282	Length:	530	Species:	Danio rerio

Alignment Length:	529	Identity:	211/529 - (39%)
Similarity:	330/529 - (62%)	Gaps:	11/529 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 ESSPDSEYTSAVPVDCRVTDLKENEMKQVDFDEDTRVLLVKQNDRLLAVGAKCTHYGAPLQTGAL 110
            |:....|.|..|   |..:||::.:||:|..||: ::|||:.|....|||..|:||||||..|.|
Zfish     2 EAKQCKEVTEMV---CLESDLQDGQMKEVLVDEN-KILLVRNNGEFTAVGGLCSHYGAPLIKGTL 62

  Fly   111 GLGRVRCPWHGACFNLENGDIEDFPGLDSLPCYRVEVGNEGQVMLRAKRSDLVNNKRLKNMVRRK 175
            ...|||||:||||||.:.||||:|||||.||.::|:| :.|:|.:.:.:.:|  .||:|.|..|.
Zfish    63 IGDRVRCPFHGACFNTKTGDIEEFPGLDCLPKFKVKV-DGGKVYVTSDQKNL--KKRVKKMSSRV 124

  Fly   176 PDDQRVFIVVGGGPSGAVAVETIRQEGFTGRLIFVCREDYLPYDRVKISKAMNLEIEQLRFRDEE 240
            |......:::||||:.....||:||..:.||::.|.:::.||.|:.|:|||||:|||::..|..:
Zfish   125 PGVNHTVVLIGGGPASLQCAETLRQNDYGGRIVMVTKDEQLPLDKTKLSKAMNIEIEKVLLRQSD 189

  Fly   241 FYKEYDIELWQGVAAEKLDTAQKELHCSNGYVVKYDKIYLATGCSAFRPPIPGVNLENVRTVREL 305
            |.::|.||:|.....:.:||..|.:...:|.:..||::.::||..|.....||..||||:.::..
Zfish   190 FLQQYGIEVWTKKEVKSVDTDAKTVTFQDGTLQNYDQLLISTGGRARPLECPGAELENVKLLQTY 254

  Fly   306 ADTKAILASITPESRVVCLGSSFIALEAAAGLVSKVQSVTVVGRENVPLKAAFGAEIGQRVLQLF 370
            .|...| ..|:...:.|.:|:|||.:|.||.|..|..||||:|....|.:|:.|::||:..:|:.
Zfish   255 EDASEI-HRISAGKKAVIVGTSFIGMEVAAYLSDKAASVTVIGTSKFPFQASLGSDIGKMTMQML 318

  Fly   371 EDNKVVMRMESGIAEIVGNEDGKVSEVVLVDDTRLPCDLLILGTGSKLNTQFLAKSGVKVNRNGS 435
            |:..|.....:|:|||.| |:|||.||||.:...||.|::|.|.|...|:.||.::.|:::.:.:
Zfish   319 EEKNVKFYTSNGVAEIRG-ENGKVKEVVLKNGEVLPADIIIAGIGVIPNSDFLKETLVEIDSHKA 382

  Fly   436 VDVTDFLESNVPDVYVGGDIANAHIHGLAHDRVNIGHYQLAQYHGRVAAINMCGGVKKLEAVPFF 500
            |.|..|:::|:|||:..||:.:..:..:.|.||||||:||||.|||:|.::|.....::..||:|
Zfish   383 VVVDKFMKTNIPDVFAAGDVVSFPLTLVGHKRVNIGHWQLAQAHGRIAGLSMLNRQVEINTVPYF 447

  Fly   501 FTLIFGKGIRYAGHG-SYKDVIIDGSMEDFKFVAYFINEADTVTAVASCGRDPIVAQFAELISQG 564
            :|::.||.|||.|:| .|.:::..||.|:.||:|::|.: :.|.|.||...||.||:.||::..|
Zfish   448 WTMLLGKSIRYTGYGEGYTEIVFKGSTEERKFLAFYIKD-EEVVAAASLNFDPAVARLAEMLLMG 511

  Fly   565 KCLGRGQIE 573
            |.:.:.|.:
Zfish   512 KRITKAQAQ 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4199	NP_001188537.1	Rieske_AIFL_N	59..154	CDD:239560	49/94 (52%)
		Pyr_redox_2	183..465	CDD:285266	102/281 (36%)
		Pyr_redox	320..402	CDD:278498	36/81 (44%)
		Reductase_C	505..577	CDD:291425	28/70 (40%)
aifm4	XP_005157647.1	Rieske_AIFL_N	13..105	CDD:239560	50/96 (52%)
		Pyr_redox_2	129..427	CDD:285266	113/299 (38%)
		TIM_phosphate_binding	<132..277	CDD:304361	50/145 (34%)
		Pyr_redox	268..349	CDD:278498	36/81 (44%)
		Reductase_C	446..519	CDD:291425	29/73 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	223	1.000	Domainoid score	I2498
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1909
OMA	1	1.010	-	-		QHG58553
OrthoDB	1	1.010	-	-		D183405at33208
OrthoFinder	1	1.000	-	-		FOG0001279
OrthoInspector	1	1.000	-	-		mtm6441
orthoMCL	1	0.900	-	-		OOG6_100481
Panther	1	1.100	-	-	LDO	PTHR43557
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R33
SonicParanoid	1	1.000	-	-		X1666
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	13.010