DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4199 and dldh

DIOPT Version :9

Sequence 1:	NP_001188537.1	Gene:	CG4199 / 31174	FlyBaseID:	FBgn0025628	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_958914.1	Gene:	dldh / 399479	ZFINID:	ZDB-GENE-040120-4	Length:	507	Species:	Danio rerio

Alignment Length:	387	Identity:	86/387 - (22%)
Similarity:	143/387 - (36%)	Gaps:	88/387 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 VVGGGPSGAVAVETIRQEGFTGRLIFVCRE-----------------------DYLPYDRV--KI 223
            |||.||.|.||.....|.||.    .||.|                       .|| |...  |.
Zfish    45 VVGSGPGGYVAAIKAAQLGFK----TVCVEKNATLGGTCLNVGCIPSKALLNNSYL-YHMAHGKD 104

  Fly   224 SKAMNLEIEQLRFRDEEFYKEYD---IELWQGVAAEKLDTAQKELHCSNGY-------------- 271
            .::..:||:.:....|:...:..   ..|..|:|  .|....|..|. ||:
Zfish   105 FESRGIEIQGISLNLEKMMAQKSGAVKALTGGIA--HLFKQNKVTHV-NGFGTITGKNQVTAKTA 166

  Fly   272 ----VVKYDKIYLATGCSAFRPPIPGVNLENVRTVRELADTKAILASITPESRVVCLGSSFIALE 332
                |:....|.:|||...  .|.||:.::....|   :.|.|:.....||..:| :|:..|.:|
Zfish   167 DGEQVINTKNILIATGSEV--TPFPGIEIDEDSVV---SSTGALSLKNVPEELIV-IGAGVIGVE 225

  Fly   333 AAA---GLVSKVQSVTVVGRENVPLKAAFGAEIGQRVLQLFEDNKVVMRMESGIAEIVGNEDGKV 394
            ..:   .|.:||.:|..:|...   ......||.:...::.:...:..::.:.:.......|||:
Zfish   226 LGSVWQRLGAKVTAVEFLGHVG---GMGIDMEISKNFQRILQKQGLKFKLSTKVMGATKRPDGKI 287

  Fly   395 SEVVLV----DDTRLPCDLLILGTGSKLNTQFLA--KSGVKVNRNGSVDVTDFLESNVPDVYVGG 453
            ...|..    .:..|.||:|::..|.:..|..|.  ..|:::::.|.:.|....::|||::|..|
Zfish   288 DVAVEAAAGGKNETLTCDVLLVCIGRRPFTGNLGLESVGIELDKRGRIPVNGRFQTNVPNIYAIG 352

  Fly   454 DIAN----AH---------IHGLAHDRVNIGHY---QLAQYHGRVAAINMCGGVKKLEAVPF 499
            |:..    ||         :.|:|...|:|.:.   .:...|..||.:.......|.|.||:
Zfish   353 DVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKTEEQLKEEGVPY 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4199	NP_001188537.1	Rieske_AIFL_N	59..154	CDD:239560
		Pyr_redox_2	183..465	CDD:285266	76/348 (22%)
		Pyr_redox	320..402	CDD:278498	15/88 (17%)
		Reductase_C	505..577	CDD:291425
dldh	NP_958914.1	PRK06327	42..507	CDD:235779	86/387 (22%)
		NADB_Rossmann	44..220	CDD:304358	44/188 (23%)
		Pyr_redox	214..286	CDD:278498	12/75 (16%)
		Glycosyltransferase_GTB_type	<282..376	CDD:299143	23/93 (25%)
		Pyr_redox_dim	388..494	CDD:280934	7/27 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910